PL416447A1 - Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy - Google Patents

Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy

Info

Publication number
PL416447A1
PL416447A1 PL416447A PL41644716A PL416447A1 PL 416447 A1 PL416447 A1 PL 416447A1 PL 416447 A PL416447 A PL 416447A PL 41644716 A PL41644716 A PL 41644716A PL 416447 A1 PL416447 A1 PL 416447A1
Authority
PL
Poland
Prior art keywords
inhibitor
application
neuraminidase
amantadine
viruses
Prior art date
Application number
PL416447A
Other languages
English (en)
Inventor
Katarzyna Kamińska
Janusz Bujnicki
Original Assignee
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie filed Critical Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie
Priority to PL416447A priority Critical patent/PL416447A1/pl
Priority to PCT/IB2017/051397 priority patent/WO2017153950A1/en
Publication of PL416447A1 publication Critical patent/PL416447A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Przedmiotem zgłoszenia są pochodne 4-hydroksyfenylo-2-oksoetylokarboksylowe o ogólnym wzorze: R1-A-R2, w którym rdzeń A stanowi związek o wzorze strukturalnym jak na rysunku, zaś R1 oznacza fenyl podstawiony dwoma C1-C4 alkilami, 1,3-benzodioksolil lub bicyklo[3.3.1]nonanyl, a R2 oznacza H, hydroksyl, grupę aminową ewentualnie podstawioną karbonylo-C1-C4-alkilem lub grupę amidową ewentualnie podstawioną C1-C4-alkilem. Przedmiotem zgłoszenia są również ich farmaceutycznie dopuszczalne sole, solwaty, polimorfy, współleki, kokryształy, proleki, tautomery, racematy, enancjomery lub diastereomery albo ich mieszaniny; jako inhibitory nukleazy wirusów posiadających genom w postaci segmentowanej nici RNA o ujemnej polarności, do stosowania jako lek, w szczególności lek przeciwwirusowy. Zgłoszenie ponadto obejmuje zastosowanie wyżej wymienionych pochodnych do wytwarzania leku do leczenia, łagodzenia lub profilaktyki infekcji wirusowych, wywoływanych przez wirusy m.in. z rodziny Orthomyxoviridae, obejmujących grypę i jej powikłania, jak również do stosowania w terapii skojarzonej z inhibitorem neuraminidazy, amantadyny, neuraminidazy, amantadyny lub rymantadyny, albo ich dowolną inną kombinacją.
PL416447A 2016-03-10 2016-03-10 Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy PL416447A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL416447A PL416447A1 (pl) 2016-03-10 2016-03-10 Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy
PCT/IB2017/051397 WO2017153950A1 (en) 2016-03-10 2017-03-09 Inhibitors of influenza virus nuclease (polymerase complex)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL416447A PL416447A1 (pl) 2016-03-10 2016-03-10 Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy

Publications (1)

Publication Number Publication Date
PL416447A1 true PL416447A1 (pl) 2017-09-11

Family

ID=59772000

Family Applications (1)

Application Number Title Priority Date Filing Date
PL416447A PL416447A1 (pl) 2016-03-10 2016-03-10 Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy

Country Status (2)

Country Link
PL (1) PL416447A1 (pl)
WO (1) WO2017153950A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA125218C2 (uk) 2016-08-10 2022-02-02 Сіоногі Енд Ко., Лтд. Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475109A (en) * 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
WO2005030224A1 (en) * 2003-09-26 2005-04-07 Nicox S.A. Nitrosylated analgesic and/or anti-inflammatory drugs having antiviral activity
KR101189823B1 (ko) * 2009-11-23 2012-10-10 한국생명공학연구원 폴리페놀성 화합물을 포함하는 인플루엔자 바이러스 감염의 예방 및 치료용 조성물 및 뉴라미니데이즈 활성의 억제용 조성물
US8859290B2 (en) * 2011-07-22 2014-10-14 Rutgers, The State University Of New Jersey Inhibitors of influenza endonuclease activity and tools for their discovery
US20150246024A1 (en) * 2012-08-20 2015-09-03 The University Of Chicago Methods and compositions for inhibiting gram positive bacteria

Also Published As

Publication number Publication date
WO2017153950A1 (en) 2017-09-14

Similar Documents

Publication Publication Date Title
MX2017011951A (es) Derivados sustituidos de indol 3 novedosos, composiciones farmaceuticas y metodos para uso.
PH12020551264A1 (en) Pyridone Derivative, Composition And Use As Antiviral Drug Thereof
MX2022010520A (es) Macrociclos peptidicos contra acinetobacter baumannii.
JOP20190115B1 (ar) مثبّطات إنزيم بولي (adp-ريبوز) بوليمراز (parp)
JP2016530314A5 (pl)
PH12015501881B1 (en) Amide compounds for the treatment of hiv
NZ739248A (en) Inhibitors of hepatitis c virus
MA37712A2 (fr) Inhibiteurs macrocycliques de virus flaviviridae
EA202190602A3 (ru) 2'-замещенные-n6-замещенные пуриновые нуклеотиды для лечения вызванных рнк-вирусом заболеваний
MD20160105A2 (ro) 2-Amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8H)-il-1,3-tiazol-4-il amide
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
EA201691401A1 (ru) Индазольные соединения в качестве ингибиторов irak4
MX2015008971A (es) Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.
MX2018009944A (es) Procedimiento para la preparacion del acido 4-fenil-5-alcoxicarbon il-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]3-oxo-5,6,8,8a- tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxilico.
PH12016500737B1 (en) Process for the preparation of a pde4 inhibitor
HRP20200408T1 (hr) Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa
PH12017502009A1 (en) Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
BR112019003320A2 (pt) compostos de heteroaril carboxamida como inibidores de ripk2
BR112018003489A2 (pt) n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
PH12017501687A1 (en) Inhibitors of hepatitis c virus polymerase
NZ725001A (en) Tricyclic compound and jak inhibitor
EA201790632A1 (ru) 4'-винилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк респираторно-синцитиального вируса
SA520420046B1 (ar) مركبات بيريدازينون ثلاثية الحلقة مندمجة وعقاقير أولية منها مفيدة لعلاج الإصابات الفيروسة المخاطية القويمة
WO2013172741A3 (ru) Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси) циклогексен-1-карбоновые кислоты, их эфиры и способ применения
PL416447A1 (pl) Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy