PL416659A1 - Peptide derivatives of S-enantiomers of 1-aminoalkylophosphonic acid diaryl esters, method for producing them and their application - Google Patents

Peptide derivatives of S-enantiomers of 1-aminoalkylophosphonic acid diaryl esters, method for producing them and their application

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Publication number
PL416659A1
PL416659A1 PL416659A PL41665916A PL416659A1 PL 416659 A1 PL416659 A1 PL 416659A1 PL 416659 A PL416659 A PL 416659A PL 41665916 A PL41665916 A PL 41665916A PL 416659 A1 PL416659 A1 PL 416659A1
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PL
Poland
Prior art keywords
derivative
enantiomers
proline
application
peptide derivatives
Prior art date
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PL416659A
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Polish (pl)
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PL227833B1 (en
Inventor
Marcin Skoreński
Józef Oleksyszyn
Marcin Sieńczyk
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Politechnika Wrocławska
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Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL416659A priority Critical patent/PL227833B1/en
Publication of PL416659A1 publication Critical patent/PL416659A1/en
Publication of PL227833B1 publication Critical patent/PL227833B1/en

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Abstract

Przedmiotem zgłoszenia są peptydowe pochodne S-enancjomerów estrów diarylowych kwasów 1-aminoalkanofosfonowych o wzorze ogólnym I, w którym w którym R1 oznacza analog proliny: pierścień piperydyny, pierścień oktadehydroindolu, dimetylocyklopropylową pochodną proliny lub bicykliczną pochodną proliny, R2 oznacza resztę tert-butyloksykarbonylową, kwasu pirazynokarboksylowego, pochodną hydrochinonu lub dipeptydową pochodną: kwas pirazynokarboksylowy-cykloheksyloglicyna oraz sposoby ich wytwarzania. Zgłoszenie dotyczy również zastosowania peptydowych pochodnych S-enancjomerów estrów diarylowych kwasów 1-aminoalkilofosfonowych o wzorze ogólnym I w którym R1 oznacza analog proliny: pierścień piperydyny, pierścień oktadehydroindolu, dimetylocyklopropylową pochodną proliny lub bicykliczną pochodną proliny, R2 oznacza resztę tert-butyloksykarbonylową, kwasu pirazynokarboksylowego, pochodną hydrochinonu lub dipeptydową pochodną: kwas pirazynokarboksylowy-cykloheksyloglicyna jako nieodwracalnych inhibitorów proteazy NS3/4A o genotypach 1a oraz 1b.The subject of the application are peptide derivatives of S-enantiomers of diaryl esters of 1-aminoalkane phosphonic acids of general formula I, in which R1 is a proline analog: piperidine ring, octadehydroindole ring, dimethylcyclopropyl proline derivative or bicyclic proline derivative, R2 is tert-butyloxycarbonyl residue pyrazinecarboxylic acid, hydroquinone derivative or dipeptide derivative: pyrazinecarboxylic acid-cyclohexylglycine and methods for their preparation. The application also relates to the use of peptide derivatives of S-enantiomers of 1-aminoalkylphosphonic acid diaryl esters of the general formula I in which R1 is a proline analog: piperidine ring, octadehydroindole ring, dimethylcyclopropyl proline derivative or bicyclic proline derivative, R2 is tert-butyloxycarbonyl residue hydroquinone derivative or dipeptide derivative: pyrazinecarboxylic acid-cyclohexylglycine as irreversible NS3 / 4A protease inhibitors of genotypes 1a and 1b.

PL416659A 2016-04-01 2016-04-01 Peptide derivatives of S-enantiomers of diaryl esters of 1-aminoalkylphosphonic acids, their preparation and application PL227833B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL416659A PL227833B1 (en) 2016-04-01 2016-04-01 Peptide derivatives of S-enantiomers of diaryl esters of 1-aminoalkylphosphonic acids, their preparation and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL416659A PL227833B1 (en) 2016-04-01 2016-04-01 Peptide derivatives of S-enantiomers of diaryl esters of 1-aminoalkylphosphonic acids, their preparation and application

Publications (2)

Publication Number Publication Date
PL416659A1 true PL416659A1 (en) 2017-02-13
PL227833B1 PL227833B1 (en) 2018-01-31

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Family Applications (1)

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PL416659A PL227833B1 (en) 2016-04-01 2016-04-01 Peptide derivatives of S-enantiomers of diaryl esters of 1-aminoalkylphosphonic acids, their preparation and application

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PL227833B1 (en) 2018-01-31

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