PL417890A1 - Method for asymmetric reduction of prochiral ketones - Google Patents

Method for asymmetric reduction of prochiral ketones

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Publication number
PL417890A1
PL417890A1 PL417890A PL41789016A PL417890A1 PL 417890 A1 PL417890 A1 PL 417890A1 PL 417890 A PL417890 A PL 417890A PL 41789016 A PL41789016 A PL 41789016A PL 417890 A1 PL417890 A1 PL 417890A1
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PL
Poland
Prior art keywords
formula
asymmetric reduction
prochiral ketones
alkoxy
diamine
Prior art date
Application number
PL417890A
Other languages
Polish (pl)
Other versions
PL231016B1 (en
Inventor
Marcin Szewczyk
Agata Bezłada
Sebastian Baś
Jacek Młynarski
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL417890A priority Critical patent/PL231016B1/en
Publication of PL417890A1 publication Critical patent/PL417890A1/en
Publication of PL231016B1 publication Critical patent/PL231016B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób asymetrycznej redukcji prochiralnych ketonów, charakteryzujący się tym, że w środowisku pozbawionym rozpuszczalnika keton o wzorze 1, gdzie: R1 i R2 oznacza niezależnie grupę: aromatyczną lub alifatyczną, w tym alkilową lub allilową, ewentualnie podstawioną podstawnikiem: alifatycznym, alkoksylowym, arylowym, alkoksylowym, aryloksylowym, nitrowym lub halogenkiem lub ich kombinacją, poddaje się reakcji z trietoksysilanem w obecności katalizatora w ilości od 0,05 do 0,3 mol%, będącego kompleksem Zn2+ z ligandem diaminowym L, będącym N,N'-dipodstawioną (R,R)-1,2-difenyloetylo-1,2-diaminą, korzystnie wybranych spośród związków o wzorze L1, L2, L3, uzyskując alkohol o wzorze 2.The subject of the application is a method of asymmetric reduction of prochiral ketones, characterized in that in a solvent-free environment, ketone of formula 1, where: R1 and R2 is independently an aromatic or aliphatic group, including alkyl or allyl, optionally substituted with an aliphatic, alkoxy, aryl, alkoxy, aryloxy, nitro or halide or a combination thereof, is reacted with triethoxysilane in the presence of a catalyst in an amount of 0.05 to 0.3 mol%, which is a Zn2 + complex with a diamine ligand L, which is N, N'-disubstituted ( R, R) -1,2-diphenylethyl-1,2-diamine, preferably selected from compounds of formula L1, L2, L3, to give the alcohol of formula 2.

PL417890A 2016-07-09 2016-07-09 Method for asymmetric reduction of prochiral ketones PL231016B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL417890A PL231016B1 (en) 2016-07-09 2016-07-09 Method for asymmetric reduction of prochiral ketones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL417890A PL231016B1 (en) 2016-07-09 2016-07-09 Method for asymmetric reduction of prochiral ketones

Publications (2)

Publication Number Publication Date
PL417890A1 true PL417890A1 (en) 2018-01-15
PL231016B1 PL231016B1 (en) 2019-01-31

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ID=60937385

Family Applications (1)

Application Number Title Priority Date Filing Date
PL417890A PL231016B1 (en) 2016-07-09 2016-07-09 Method for asymmetric reduction of prochiral ketones

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Publication number Publication date
PL231016B1 (en) 2019-01-31

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