PL418019A1 - Sposób wytwarzania brekspiprazolu, związki pośrednie stosowane w tym sposobie oraz sposób ich wytwarzania - Google Patents

Sposób wytwarzania brekspiprazolu, związki pośrednie stosowane w tym sposobie oraz sposób ich wytwarzania

Info

Publication number
PL418019A1
PL418019A1 PL418019A PL41801916A PL418019A1 PL 418019 A1 PL418019 A1 PL 418019A1 PL 418019 A PL418019 A PL 418019A PL 41801916 A PL41801916 A PL 41801916A PL 418019 A1 PL418019 A1 PL 418019A1
Authority
PL
Poland
Prior art keywords
producing
brexpiprazole
compounds used
intermediate compounds
preparation
Prior art date
Application number
PL418019A
Other languages
English (en)
Other versions
PL233778B1 (pl
Inventor
Rafał Rusiecki
Marcin Śnieżek
Original Assignee
Adamed Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Spółka Z Ograniczoną Odpowiedzialnością filed Critical Adamed Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL418019A priority Critical patent/PL233778B1/pl
Priority to EP17740021.5A priority patent/EP3487854A1/en
Priority to PCT/EP2017/068058 priority patent/WO2018015354A1/en
Publication of PL418019A1 publication Critical patent/PL418019A1/pl
Publication of PL233778B1 publication Critical patent/PL233778B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania brekspiprazolu obejmujący etap a) reakcji 4-[(2-okso-1,2-dihydrochinolin-7-yl)oksy]butanalu z 1-(1-benzotiofen-4-ylo)piperazyną lub jej solą w rozpuszczalniku ewentualnie w obecności katalizatora oraz etap b) redukcji soli iminiowej utworzonej w etapie a) za pomocą środka redukującego w rozpuszczalniku ewentualnie w obecności katalizatora. Przedmiotem zgłoszenia są również związki pośrednie stosowane w wytwarzaniu brekspiprazolu oraz sposób wytwarzania tych związków pośrednich.
PL418019A 2016-07-19 2016-07-19 Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu PL233778B1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL418019A PL233778B1 (pl) 2016-07-19 2016-07-19 Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu
EP17740021.5A EP3487854A1 (en) 2016-07-19 2017-07-17 The method for manufacture of brexpiprazole, intermediates used in this method, and the method for manufacture thereof
PCT/EP2017/068058 WO2018015354A1 (en) 2016-07-19 2017-07-17 The method for manufacture of brexpiprazole, intermediates used in this method, and the method for manufacture thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL418019A PL233778B1 (pl) 2016-07-19 2016-07-19 Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu

Publications (2)

Publication Number Publication Date
PL418019A1 true PL418019A1 (pl) 2018-01-29
PL233778B1 PL233778B1 (pl) 2019-11-29

Family

ID=59350968

Family Applications (1)

Application Number Title Priority Date Filing Date
PL418019A PL233778B1 (pl) 2016-07-19 2016-07-19 Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu

Country Status (3)

Country Link
EP (1) EP3487854A1 (pl)
PL (1) PL233778B1 (pl)
WO (1) WO2018015354A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112858524B (zh) * 2021-02-25 2022-12-20 丽珠集团新北江制药股份有限公司 一种依匹哌唑有关物质的检测方法和应用
WO2023067664A1 (ja) * 2021-10-18 2023-04-27 大塚製薬株式会社 ベンゾチオフェン化合物の新規結晶形及びその製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
JP2011136906A (ja) * 2008-04-18 2011-07-14 Otsuka Pharmaceut Co Ltd 複素環化合物
ES2601457T3 (es) 2011-07-28 2017-02-15 Otsuka Pharmaceutical Co., Ltd. Método para producir compuestos de benzo[b]tiofeno
JO3227B1 (ar) 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
TWI562991B (en) 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
JP6594351B2 (ja) 2014-06-16 2019-10-23 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー 新規中間体を含むアルキル化アリールピペラジン及びアルキル化アリールピペリジン化合物の製造方法
CN104447723A (zh) 2014-11-28 2015-03-25 瑞阳制药有限公司 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法
CN105461703B (zh) 2014-12-29 2019-05-17 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN104844585B (zh) 2015-04-15 2021-05-11 重庆医药工业研究院有限责任公司 一种制备依匹哌唑的方法
CN104829602A (zh) 2015-04-15 2015-08-12 重庆医药工业研究院有限责任公司 一种依匹哌唑的制备方法
CN105061414B (zh) 2015-07-21 2019-01-01 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
CN105440026A (zh) 2015-12-04 2016-03-30 上海勋和医药科技有限公司 依匹哌唑的制备方法
CN105461704A (zh) 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法
CN105399736B (zh) 2016-01-07 2018-10-19 安徽省逸欣铭医药科技有限公司 一种依匹哌唑新的制备方法

Also Published As

Publication number Publication date
PL233778B1 (pl) 2019-11-29
WO2018015354A1 (en) 2018-01-25
EP3487854A1 (en) 2019-05-29

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