PL421981A1 - Method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1 - Google Patents
Method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1Info
- Publication number
- PL421981A1 PL421981A1 PL421981A PL42198117A PL421981A1 PL 421981 A1 PL421981 A1 PL 421981A1 PL 421981 A PL421981 A PL 421981A PL 42198117 A PL42198117 A PL 42198117A PL 421981 A1 PL421981 A1 PL 421981A1
- Authority
- PL
- Poland
- Prior art keywords
- formula
- obtaining
- containing ibuprofen
- ibuprofen
- phosphocholine
- Prior art date
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical group CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001680 ibuprofen Drugs 0.000 title abstract 3
- IHNKQIMGVNPMTC-UHFFFAOYSA-N (2-hydroxy-3-octadecanoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C IHNKQIMGVNPMTC-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- JGFBRKRYDCGYKD-UHFFFAOYSA-N dibutyl(oxo)tin Chemical compound CCCC[Sn](=O)CCCC JGFBRKRYDCGYKD-UHFFFAOYSA-N 0.000 abstract 1
- 238000010898 silica gel chromatography Methods 0.000 abstract 1
- -1 sn-glycerol-3-phosphocholine acetal Chemical class 0.000 abstract 1
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania 2-lizofosfatydylocholiny zawierającej ibuprofen w pozycji sn-1 o wzorze 3, polegający na tym, że chlorek ibuprofenu (wzór 1) poddaje się reakcji z acetalem sn-glicero-3-fosfocholiny z tlenkiem dibutylocyny (wzór 2) rozpuszczonymi w 2-propanolu w obecności trietyloaminy, po czym całość miesza się przez co najmniej 30 minut, a surowy produkt, którym jest 1-[2'-(4"-izobutylofenylo)]propanoilo-2-hydroksy-sn-glicero-3-fosfocholina (wzór 3), oczyszcza się za pomocą chromatografii kolumnowej na żelu krzemionkowym.The subject of the application is a method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1 of formula 3, whereby ibuprofen chloride (formula 1) is reacted with sn-glycerol-3-phosphocholine acetal with dibutyltin oxide (formula 2) dissolved in 2-propanol in the presence of triethylamine, after which the whole is mixed for at least 30 minutes and the crude product is 1- [2 '- (4 "-isobutylphenyl)] propanoyl-2-hydroxy-sn-glycerol-3- phosphocholine (formula 3), purified by silica gel column chromatography.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL421981A PL238965B1 (en) | 2017-06-22 | 2017-06-22 | Method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL421981A PL238965B1 (en) | 2017-06-22 | 2017-06-22 | Method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL421981A1 true PL421981A1 (en) | 2019-01-02 |
| PL238965B1 PL238965B1 (en) | 2021-10-25 |
Family
ID=64899004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL421981A PL238965B1 (en) | 2017-06-22 | 2017-06-22 | Method for obtaining 2-lysophosphatidylcholine containing ibuprofen in position sn-1 |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL238965B1 (en) |
-
2017
- 2017-06-22 PL PL421981A patent/PL238965B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL238965B1 (en) | 2021-10-25 |
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