PL422073A1 - Fosfatydylocholiny oraz sposób ich otrzymywania - Google Patents
Fosfatydylocholiny oraz sposób ich otrzymywaniaInfo
- Publication number
- PL422073A1 PL422073A1 PL422073A PL42207317A PL422073A1 PL 422073 A1 PL422073 A1 PL 422073A1 PL 422073 A PL422073 A PL 422073A PL 42207317 A PL42207317 A PL 42207317A PL 422073 A1 PL422073 A1 PL 422073A1
- Authority
- PL
- Poland
- Prior art keywords
- obtaining
- lyso
- phosphocholine
- propanoyl
- application
- Prior art date
Links
- 150000008105 phosphatidylcholines Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 3
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 abstract 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 abstract 1
- 229960000991 ketoprofen Drugs 0.000 abstract 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
- 229960002009 naproxen Drugs 0.000 abstract 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Przedmiotem zgłoszenia są pochodne fosfatydylocholiny, zawierające w pozycji sn-1 naproksen albo ketoprofen oraz resztę kwasu palmitynowego w pozycji sn-2. Zgłoszenie obejmuje też sposób otrzymywania pochodnych fosfatydylocholiny, który polega na tym, że 1-[2'-(6"-metoksynaftalenylo)]propanoilo-2-lizo-sn-glicero-3-fosfocholinę albo 1-[2'-(3"-benzoilofenylo)]propanoilo-2-lizo-sn-glicero-3-fosfocholinę poddaje się estryfikacji kwasem palmitynowym w bezwodnym rozpuszczalniku, z udziałem N,N'-dicykloheksylokarbodiimidu w obecności 4-(N,N-dimetyloamino)pirydyny.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422073A PL232663B1 (pl) | 2017-06-30 | 2017-06-30 | Fosfatydylocholiny oraz sposób ich otrzymywania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422073A PL232663B1 (pl) | 2017-06-30 | 2017-06-30 | Fosfatydylocholiny oraz sposób ich otrzymywania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL422073A1 true PL422073A1 (pl) | 2019-01-02 |
| PL232663B1 PL232663B1 (pl) | 2019-07-31 |
Family
ID=64899048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL422073A PL232663B1 (pl) | 2017-06-30 | 2017-06-30 | Fosfatydylocholiny oraz sposób ich otrzymywania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL232663B1 (pl) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0161519A2 (de) * | 1984-05-15 | 1985-11-21 | Chemie Linz Aktiengesellschaft | Derivate des Glycerophosphocholins und Glycerophosphoethanolamins, ihre Herstellung und Verwendung |
| JP2000281688A (ja) * | 1999-03-29 | 2000-10-10 | Nof Corp | 混合酸型１，２−ジアシル−３−グリセロリン脂質の製造方法 |
| WO2002090560A2 (en) * | 2001-05-03 | 2002-11-14 | Enzymotec Ltd. | Process for the production of phospholipids |
| PL415744A1 (pl) * | 2016-01-11 | 2016-08-01 | Uniwersytet Przyrodniczy we Wrocławiu | 1-Anyżoilo-2-hydroksy-sn-glicero-3-fosfocholina oraz sposób jej otrzymywania |
| PL419199A1 (pl) * | 2016-10-21 | 2017-02-27 | Uniwersytet Przyrodniczy we Wrocławiu | 1'-(3,7,11,15-Tetrametylo-3-winyloheksadecylo)-2'-hydroksy-sn-glicero-3'-fosfatydylocholina i sposób jej otrzymywania |
-
2017
- 2017-06-30 PL PL422073A patent/PL232663B1/pl unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0161519A2 (de) * | 1984-05-15 | 1985-11-21 | Chemie Linz Aktiengesellschaft | Derivate des Glycerophosphocholins und Glycerophosphoethanolamins, ihre Herstellung und Verwendung |
| JP2000281688A (ja) * | 1999-03-29 | 2000-10-10 | Nof Corp | 混合酸型１，２−ジアシル−３−グリセロリン脂質の製造方法 |
| WO2002090560A2 (en) * | 2001-05-03 | 2002-11-14 | Enzymotec Ltd. | Process for the production of phospholipids |
| PL415744A1 (pl) * | 2016-01-11 | 2016-08-01 | Uniwersytet Przyrodniczy we Wrocławiu | 1-Anyżoilo-2-hydroksy-sn-glicero-3-fosfocholina oraz sposób jej otrzymywania |
| PL419199A1 (pl) * | 2016-10-21 | 2017-02-27 | Uniwersytet Przyrodniczy we Wrocławiu | 1'-(3,7,11,15-Tetrametylo-3-winyloheksadecylo)-2'-hydroksy-sn-glicero-3'-fosfatydylocholina i sposób jej otrzymywania |
Also Published As
| Publication number | Publication date |
|---|---|
| PL232663B1 (pl) | 2019-07-31 |
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