PL424227A1 - Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists - Google Patents

Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists

Info

Publication number
PL424227A1
PL424227A1 PL424227A PL42422718A PL424227A1 PL 424227 A1 PL424227 A1 PL 424227A1 PL 424227 A PL424227 A PL 424227A PL 42422718 A PL42422718 A PL 42422718A PL 424227 A1 PL424227 A1 PL 424227A1
Authority
PL
Poland
Prior art keywords
phenyl
derivatives
hexynoic acid
gpr40 agonists
unsaturated
Prior art date
Application number
PL424227A
Other languages
Polish (pl)
Other versions
PL233938B1 (en
Inventor
Mateusz Mach
Radosław Dzida
Damian SMUGA
Filip STELMACH
Mikołaj Matłoka
Katarzyna Bazydło
Krzysztof DUBIEL
Maciej Wieczorek
Jerzy Pieczykolan
Original Assignee
Celon Pharma Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Spółka Akcyjna filed Critical Celon Pharma Spółka Akcyjna
Priority to PL424227A priority Critical patent/PL233938B1/en
Priority to PL19701029.1T priority patent/PL3737470T3/en
Priority to MX2020007283A priority patent/MX2020007283A/en
Priority to AU2019205093A priority patent/AU2019205093B2/en
Priority to KR1020207022946A priority patent/KR102705659B1/en
Priority to JP2020537648A priority patent/JP7289305B2/en
Priority to CN201980007754.0A priority patent/CN111757770B/en
Priority to CA3087712A priority patent/CA3087712C/en
Priority to BR112020013694-8A priority patent/BR112020013694A2/en
Priority to ES19701029T priority patent/ES2939720T3/en
Priority to DK19701029.1T priority patent/DK3737470T5/en
Priority to EP19701029.1A priority patent/EP3737470B9/en
Priority to PT197010291T priority patent/PT3737470T/en
Priority to PCT/EP2019/050194 priority patent/WO2019134984A1/en
Priority to FIEP19701029.1T priority patent/FI3737470T3/en
Priority to US16/960,700 priority patent/US11964938B2/en
Publication of PL424227A1 publication Critical patent/PL424227A1/en
Publication of PL233938B1 publication Critical patent/PL233938B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Przedmiotem zgłoszenia jest związek o wzorze ogólnym (I), w którym R oznacza prostą lub rozgałęzioną, pierwszorzędową lub drugorzędową acykliczną grupę węglowodorową C3 - C15, która może być nasycona lub nienasycona, lub prostą lub rozgałęzioną, pierwszorzędową lub drugorzędową acykliczną grupę węglowodorową C3 - C15, która może być nasycona lub nienasycona i w której jeden lub więcej niż jeden z atomów wodoru jest zastąpione atomem fluoru; - X oznacza atom wodoru lub atom chlorowca, oraz jego sole. Związek znajduje zastosowanie jako lek do leczenia cukrzycy.The subject of the application is a compound of the general formula (I), wherein R is a straight or branched, primary or secondary C3-C15 acyclic hydrocarbon group, which can be saturated or unsaturated, or a straight or branched, primary or secondary C3-C15 acyclic hydrocarbon group which can be saturated or unsaturated and in which one or more of the hydrogen atoms is replaced by a fluorine atom; - X is hydrogen or halogen, and its salts. The compound finds use as a medicine for the treatment of diabetes.

PL424227A 2018-01-08 2018-01-08 Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists PL233938B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
PL424227A PL233938B1 (en) 2018-01-08 2018-01-08 Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists
PL19701029.1T PL3737470T3 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
MX2020007283A MX2020007283A (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists.
AU2019205093A AU2019205093B2 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists
KR1020207022946A KR102705659B1 (en) 2018-01-08 2019-01-07 3-Phenyl-4-hexynic acid derivatives as GPR40 agonists
JP2020537648A JP7289305B2 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists
CN201980007754.0A CN111757770B (en) 2018-01-08 2019-01-07 3-Phenyl-4-hexynoic acid derivatives as GPR40 agonists
CA3087712A CA3087712C (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
BR112020013694-8A BR112020013694A2 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexinoic acid derivatives as gpr40 agonists
ES19701029T ES2939720T3 (en) 2018-01-08 2019-01-07 3-Phenyl-4-hexynoic acid derivatives as GPR40 agonists
DK19701029.1T DK3737470T5 (en) 2018-01-08 2019-01-07 3-PHENYL-4-HEXYNIC ACID DERIVATIVES AS GPR40 AGONISTS
EP19701029.1A EP3737470B9 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
PT197010291T PT3737470T (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
PCT/EP2019/050194 WO2019134984A1 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
FIEP19701029.1T FI3737470T3 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as gpr40 agonists
US16/960,700 US11964938B2 (en) 2018-01-08 2019-01-07 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL424227A PL233938B1 (en) 2018-01-08 2018-01-08 Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists

Publications (2)

Publication Number Publication Date
PL424227A1 true PL424227A1 (en) 2019-07-15
PL233938B1 PL233938B1 (en) 2019-12-31

Family

ID=67209683

Family Applications (1)

Application Number Title Priority Date Filing Date
PL424227A PL233938B1 (en) 2018-01-08 2018-01-08 Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists

Country Status (1)

Country Link
PL (1) PL233938B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047859A1 (en) * 1999-12-07 2001-07-05 Karo Bio Ab Compounds active at the glucocorticoid receptor
WO2002057783A2 (en) * 2000-12-22 2002-07-25 Glaxo Group Limited Method of screening for gpr40 ligands
WO2002083616A1 (en) * 2001-04-10 2002-10-24 Sankyo Company, Limited α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE
WO2004106276A1 (en) * 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited Condensed ring compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047859A1 (en) * 1999-12-07 2001-07-05 Karo Bio Ab Compounds active at the glucocorticoid receptor
WO2002057783A2 (en) * 2000-12-22 2002-07-25 Glaxo Group Limited Method of screening for gpr40 ligands
WO2002083616A1 (en) * 2001-04-10 2002-10-24 Sankyo Company, Limited α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE
WO2004106276A1 (en) * 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited Condensed ring compound

Also Published As

Publication number Publication date
PL233938B1 (en) 2019-12-31

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