PL424712A1 - Sposób izolowania czystego składnika siarczanu polimyksyny E - Google Patents
Sposób izolowania czystego składnika siarczanu polimyksyny EInfo
- Publication number
- PL424712A1 PL424712A1 PL424712A PL42471218A PL424712A1 PL 424712 A1 PL424712 A1 PL 424712A1 PL 424712 A PL424712 A PL 424712A PL 42471218 A PL42471218 A PL 42471218A PL 424712 A1 PL424712 A1 PL 424712A1
- Authority
- PL
- Poland
- Prior art keywords
- sulfate
- polymyxin
- pure
- polymixin
- isolating
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 title abstract 2
- 108010078777 Colistin Proteins 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- RIVWZNNHCTXSOL-JCRURNCPSA-N colistin A sulfate Polymers [O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.CC[C@@H](C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC[NH3+])NC1=O.CC[C@@H](C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC[NH3+])NC1=O RIVWZNNHCTXSOL-JCRURNCPSA-N 0.000 abstract 2
- ARWLUFSLVSQRNF-WQZLNJOZSA-N colistin B sulfate Polymers [O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.CC(C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC[NH3+])NC1=O.CC(C)CCCCC(=O)N[C@@H](CC[NH3+])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC[NH3+])C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC[NH3+])NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC[NH3+])NC1=O ARWLUFSLVSQRNF-WQZLNJOZSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 229960001127 colistin sulfate Drugs 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 1
- YKQOSKADJPQZHB-YNWHQGOSSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1s)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-YNWHQGOSSA-N 0.000 abstract 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002953 preparative HPLC Methods 0.000 abstract 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania czystego składnika siarczanu polimyksyny E, zwłaszcza wybranego spośród: siarczanu polimyksyny E1 lub siarczanu polimyksyny E2, za pomocą chromatografii w układzie odwróconych faz, zwłaszcza preparatywnej HPLC, w którym wodny roztwór mieszaniny zawierającej siarczan polimyksyny E1 i siarczan polimyksyny E2, zwłaszcza wodny roztwór siarczanu kolistyny nanosi się na kolumnę chromatograficzną i następnie wymywa się eluentem, przy czym zbiera się frakcję odcieku zawierającą wybrany składnik. W powyższym sposobie możliwe jest nanoszenie na kolumnę dużych ilości rozdzielanego preparatu. Pozwala to na wykorzystanie tego rozwiązania do prowadzenia rozdziału w skali przemysłowej.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424712A PL239311B1 (pl) | 2018-02-28 | 2018-02-28 | Sposób izolowania czystego składnika siarczanu polimyksyny E |
| PCT/PL2019/050012 WO2019168421A1 (en) | 2018-02-28 | 2019-02-28 | A method for isolation of pure polymyxin e sulfate component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424712A PL239311B1 (pl) | 2018-02-28 | 2018-02-28 | Sposób izolowania czystego składnika siarczanu polimyksyny E |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424712A1 true PL424712A1 (pl) | 2019-09-09 |
| PL239311B1 PL239311B1 (pl) | 2021-11-22 |
Family
ID=67805777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424712A PL239311B1 (pl) | 2018-02-28 | 2018-02-28 | Sposób izolowania czystego składnika siarczanu polimyksyny E |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL239311B1 (pl) |
| WO (1) | WO2019168421A1 (pl) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011051070A1 (en) * | 2009-10-30 | 2011-05-05 | Xellia Pharmaceuticals Aps | Method for purification of colistin and purified colistin components |
| CN103396475A (zh) * | 2013-08-06 | 2013-11-20 | 深圳翰宇药业股份有限公司 | 一种纯固相合成多肽类抗生素Colistin的方法 |
| CN104672309A (zh) * | 2013-11-29 | 2015-06-03 | 江苏汉邦科技有限公司 | 一种硫酸粘菌素的纯化方法 |
-
2018
- 2018-02-28 PL PL424712A patent/PL239311B1/pl unknown
-
2019
- 2019-02-28 WO PCT/PL2019/050012 patent/WO2019168421A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011051070A1 (en) * | 2009-10-30 | 2011-05-05 | Xellia Pharmaceuticals Aps | Method for purification of colistin and purified colistin components |
| CN103396475A (zh) * | 2013-08-06 | 2013-11-20 | 深圳翰宇药业股份有限公司 | 一种纯固相合成多肽类抗生素Colistin的方法 |
| CN104672309A (zh) * | 2013-11-29 | 2015-06-03 | 江苏汉邦科技有限公司 | 一种硫酸粘菌素的纯化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL239311B1 (pl) | 2021-11-22 |
| WO2019168421A1 (en) | 2019-09-06 |
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