PL425085A1 - Method for obtaining nanoemulsion that contains hyaluronic acid - Google Patents
Method for obtaining nanoemulsion that contains hyaluronic acidInfo
- Publication number
- PL425085A1 PL425085A1 PL425085A PL42508518A PL425085A1 PL 425085 A1 PL425085 A1 PL 425085A1 PL 425085 A PL425085 A PL 425085A PL 42508518 A PL42508518 A PL 42508518A PL 425085 A1 PL425085 A1 PL 425085A1
- Authority
- PL
- Poland
- Prior art keywords
- hyaluronic acid
- preparing
- acid
- obtaining
- nanoemulsion
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
- 229920002674 hyaluronan Polymers 0.000 title abstract 4
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000007908 nanoemulsion Substances 0.000 title abstract 3
- 239000012071 phase Substances 0.000 abstract 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920002545 silicone oil Polymers 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
- 239000008347 soybean phospholipid Substances 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania nanoemulsji zawierającej kwas hialuronowy. Sposób ten polega na tym, że przygotowuje się fazę wodną poprzez rozpuszczenie w wodzie kwasu hialuronowego lub jego soli, co najmniej jednej substancji nawilżającej, karboksymetylocelulozy sodowej, kwasu askorbinowego, co najmniej jednego konserwantu, co najmniej jednego humektantu oraz przygotowuje się fazę olejową poprzez rozpuszczenie i podgrzanie lecytyny sojowej, witaminy E, oleju silikonowego, kwasu stearynowego, alkoholu cetarylowego, kwasu palmitynowego lub oleju rycynowego, po czym fazę wodną podgrzewa się i dodaje się do niej fazę olejową, następnie całość homogenizuje się. Przedmiotem wynalazku jest także sposób otrzymywania nanoemulsji z kwasem hialuronowym przy pomocy ultradźwięków.The subject of the application is a method of preparing a nanoemulsion containing hyaluronic acid. The method consists in preparing an aqueous phase by dissolving hyaluronic acid or a salt thereof in water, at least one moisturizing substance, sodium carboxymethyl cellulose, ascorbic acid, at least one preservative, at least one humectant, and preparing an oil phase by dissolving and heating soy lecithin, vitamin E, silicone oil, stearic acid, cetaryl alcohol, palmitic acid or castor oil, then the water phase is heated and the oil phase is added to it, then the whole is homogenized. The subject of the invention is also a method of obtaining nanoemulsions with hyaluronic acid by means of ultrasound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL425085A PL236103B1 (en) | 2018-03-28 | 2018-03-28 | Method for obtaining nanoemulsion that contains hyaluronic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL425085A PL236103B1 (en) | 2018-03-28 | 2018-03-28 | Method for obtaining nanoemulsion that contains hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL425085A1 true PL425085A1 (en) | 2019-10-07 |
| PL236103B1 PL236103B1 (en) | 2020-12-14 |
Family
ID=68099375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL425085A PL236103B1 (en) | 2018-03-28 | 2018-03-28 | Method for obtaining nanoemulsion that contains hyaluronic acid |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236103B1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL212389B1 (en) * | 2010-08-06 | 2012-09-28 | Politechnika Wroclawska | Process for the preparation of oil in water nanoemulsions |
| CN106551870A (en) * | 2017-01-05 | 2017-04-05 | 云南祥琬生物科技有限公司 | A kind of compositionss with crease-resistant skin lightening effect, facial film and preparation method thereof |
| CN107714504A (en) * | 2017-08-01 | 2018-02-23 | 杭州惠博士健康产业有限公司 | A kind of same human-like collagen composition and its applied in cosmetics |
-
2018
- 2018-03-28 PL PL425085A patent/PL236103B1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL212389B1 (en) * | 2010-08-06 | 2012-09-28 | Politechnika Wroclawska | Process for the preparation of oil in water nanoemulsions |
| CN106551870A (en) * | 2017-01-05 | 2017-04-05 | 云南祥琬生物科技有限公司 | A kind of compositionss with crease-resistant skin lightening effect, facial film and preparation method thereof |
| CN107714504A (en) * | 2017-08-01 | 2018-02-23 | 杭州惠博士健康产业有限公司 | A kind of same human-like collagen composition and its applied in cosmetics |
Non-Patent Citations (2)
| Title |
|---|
| MARIA MRUKOT, KOSMETOLOGIA RECEPTARIUSZ, 2006 * |
| MAZIDLA.COM, 22 November 2008 (2008-11-22), Retrieved from the Internet <URL:https://www.mazidla.com/serum-z-witamina-c-15-wit.-e-1-lecytyna-hlb-1-20 7-kwas-alfa-liponowy-dla-cery-tlustej-i-tradzi> * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL236103B1 (en) | 2020-12-14 |
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