PL425549A1 - Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it - Google Patents

Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it

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Publication number
PL425549A1
PL425549A1 PL42554918A PL42554918A PL425549A1 PL 425549 A1 PL425549 A1 PL 425549A1 PL 42554918 A PL42554918 A PL 42554918A PL 42554918 A PL42554918 A PL 42554918A PL 425549 A1 PL425549 A1 PL 425549A1
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PL
Poland
Prior art keywords
dimethylphenyl
dihydrofuran
cis
bromethyl
obtaining
Prior art date
Application number
PL42554918A
Other languages
Polish (pl)
Other versions
PL238122B1 (en
Inventor
Witold Gładkowski
Angelika Sysak
Aleksandra Pawlak
Aleksandra Włoch
Bożena Obmińska-Mrukowicz
Halina Kleszczyńska
Marcelina Mazur
Original Assignee
Wrocław University Of Environmental And Life Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wrocław University Of Environmental And Life Sciences filed Critical Wrocław University Of Environmental And Life Sciences
Priority to PL425549(22)20180515A priority Critical patent/PL238122B1/en
Publication of PL425549A1 publication Critical patent/PL425549A1/en
Publication of PL238122B1 publication Critical patent/PL238122B1/en

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  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Zgłoszenie dotyczy optycznie czynnego cis-(4R,5R,6S)-5-(1-bromoetylo)-4-(2',5'-dimetylofenylo)-dihydrofuran-2-onu o wzorze 1, oraz sposobu jego otrzymywania. Sposób ten polega na tym, że kwas (S,E)-3-(2',5'-dimetylofenylo)-heks-4-enowy poddaje się reakcji bromolaktonizacji otrzymując mieszaninę produktów, z której następnie metodą chromatografii kolumnowej wydziela się w postaci czystej cis-(4R,5R,6S)-5-(1-bromoetylo)-4-(2',5'-dimetylofenylo)-dihydrofuran-2-on.The application relates to optically active cis- (4R, 5R, 6S) -5- (1-bromoethyl) -4- (2 ', 5'-dimethylphenyl) -dihydrofuran-2-one of the formula I and a method for its preparation. In this method, (S, E) -3- (2 ', 5'-dimethylphenyl) -hex-4-enoic acid is subjected to a bromolactonization reaction to obtain a mixture of products, which is then separated by column chromatography in pure form. cis- (4R, 5R, 6S) -5- (1-bromoethyl) -4- (2 ', 5'-dimethylphenyl) -dihydrofuran-2-one.

PL425549(22)20180515A 2018-05-15 2018-05-15 Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it PL238122B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL425549(22)20180515A PL238122B1 (en) 2018-05-15 2018-05-15 Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL425549(22)20180515A PL238122B1 (en) 2018-05-15 2018-05-15 Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it

Publications (2)

Publication Number Publication Date
PL425549A1 true PL425549A1 (en) 2019-11-18
PL238122B1 PL238122B1 (en) 2021-07-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL425549(22)20180515A PL238122B1 (en) 2018-05-15 2018-05-15 Cis-(4R,5R,6S)-5-(1-bromethyl)-4-(2',5'-dimethylphenyl)-dihydrofuran-2-one and method for obtaining it

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PL (1) PL238122B1 (en)

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PL238122B1 (en) 2021-07-05

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