PL426731A1 - - Google Patents

Info

Publication number
PL426731A1
PL426731A1 PL42673118A PL42673118A PL426731A1 PL 426731 A1 PL426731 A1 PL 426731A1 PL 42673118 A PL42673118 A PL 42673118A PL 42673118 A PL42673118 A PL 42673118A PL 426731 A1 PL426731 A1 PL 426731A1
Authority
PL
Poland
Prior art keywords
compound
derivative
glycoconjugate
methotrexate
innovative
Prior art date
Application number
PL42673118A
Other languages
Polish (pl)
Other versions
PL242529B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to PL426731A priority Critical patent/PL242529B1/en
Publication of PL426731A1 publication Critical patent/PL426731A1/pl
Publication of PL242529B1 publication Critical patent/PL242529B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest związek będący glikokoniugatową pochodną metotreksatu i glukozy, jak również sposób syntezy tego związku. Nowa pochodna wykazuje działanie przeciwnowotworowe i znajduje zastosowanie w przemyśle farmaceutycznym i weterynaryjnym, jako element innowacyjnej i selektywnej terapii przeciwnowotworowej.The subject of the application is a compound which is a glycoconjugate derivative of methotrexate and glucose, as well as a method for the synthesis of this compound. The new derivative has anti-cancer activity and is used in the pharmaceutical and veterinary industries as an element of an innovative and selective anti-cancer therapy.

PL426731A 2018-08-20 2018-08-20 Glycoconjugate derivative of methotrexate and glucose PL242529B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426731A PL242529B1 (en) 2018-08-20 2018-08-20 Glycoconjugate derivative of methotrexate and glucose

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426731A PL242529B1 (en) 2018-08-20 2018-08-20 Glycoconjugate derivative of methotrexate and glucose

Publications (2)

Publication Number Publication Date
PL426731A1 true PL426731A1 (en) 2020-02-24
PL242529B1 PL242529B1 (en) 2023-03-06

Family

ID=84701908

Family Applications (1)

Application Number Title Priority Date Filing Date
PL426731A PL242529B1 (en) 2018-08-20 2018-08-20 Glycoconjugate derivative of methotrexate and glucose

Country Status (1)

Country Link
PL (1) PL242529B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022260545A1 (en) * 2021-06-11 2022-12-15 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu Synthesis of a novel glucose-conjugated methotrexate and its application for the treatment and prevention of neoplasms
WO2022260546A1 (en) * 2021-06-11 2022-12-15 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu A glucose-methotrexate conjugate for use in preventing or treating autoimmune diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022260545A1 (en) * 2021-06-11 2022-12-15 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu Synthesis of a novel glucose-conjugated methotrexate and its application for the treatment and prevention of neoplasms
WO2022260546A1 (en) * 2021-06-11 2022-12-15 Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu A glucose-methotrexate conjugate for use in preventing or treating autoimmune diseases

Also Published As

Publication number Publication date
PL242529B1 (en) 2023-03-06

Similar Documents

Publication Publication Date Title
CR20200140A (en) Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof
DK3804716T3 (en) PHARMACEUTICAL COMBINATION, COMPOSITION AND COMBINATION PREPARATION COMPRISING GLUCOKINASE ACTIVATOR AND SGLT-2 INHIBITOR AND METHODS FOR THE PRODUCTION AND USES THEREOF
MX380122B (en) Benzofuran derivative, its preparation method, and its uses in medicines.
MX378806B (en) ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS.
EA201170227A1 (en) ИМИДАЗОЛКАРБОКСАМИДЫ
EP4628094A3 (en) BAFF-R ANTIBODIES AND USES
BR112021023024A2 (en) Antibody against claudin 18a2 and its use
CR20190387A (en) ANTIBODIES AGAINST TRYPTASE, COMPOSITIONS OF THESE AND USES OF THEM
CY1123231T1 (en) TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR THE TREATMENT OF PAIN AND PAIN-RELATED CONDITIONS
SA519410093B1 (en) Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
MX382347B (en) PYRIDINECARBOXAMIDE DERIVATIVES, THEIR PREPARATION METHOD AND THEIR PHARMACEUTICAL USES.
EA201991580A1 (en) PYRIMIDINE COMPOUND AND ITS PHARMACEUTICAL USE
SA522431304B1 (en) Preparation of lasmiditan and its acetate salt
WO2018067520A3 (en) Therapeutic agents and methods:
EP4570317A3 (en) Compounds for the treatment of bovine or swine respiratory disease
MY210476A (en) Vitamin d pediatric dosage forms, methods of making and using
BR112018004310A2 (en) spinosine derivatives and preparation method
EP3339307A8 (en) Nitrogen containing bicyclic derivatives for treating pain and pain related conditions
MX2018010801A (en) a-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF.
PL426731A1 (en)
BRPI0408848A8 (en) PHARMACEUTICAL COMPOSITIONS OF THE CYCLODEXTRIN-CLADRIBINE COMPLEX, USES OF THE SAID COMPLEX, AS WELL AS PROCESSES FOR THEIR PREPARATION
BR112017025872A2 (en) multispecific binding proteins
BR112018071363A2 (en) oral nicotinamide pharmaceutical compositions
PH12017501869A1 (en) (s)-2'-vinyl-abscisic acid derivatives
MX2020006292A (en) Amino acid carbamate complexes.