PL426879A1 - Combination of isothiocyanates with organic selen compounds in drug carriers as a new pharmaceutical with antitumor activity - Google Patents

Combination of isothiocyanates with organic selen compounds in drug carriers as a new pharmaceutical with antitumor activity

Info

Publication number
PL426879A1
PL426879A1 PL426879A PL42687918A PL426879A1 PL 426879 A1 PL426879 A1 PL 426879A1 PL 426879 A PL426879 A PL 426879A PL 42687918 A PL42687918 A PL 42687918A PL 426879 A1 PL426879 A1 PL 426879A1
Authority
PL
Poland
Prior art keywords
selen
isothiocyanates
compounds
organic
combination
Prior art date
Application number
PL426879A
Other languages
Polish (pl)
Other versions
PL238526B1 (en
Inventor
Katarzyna WIKTORSKA
Lidia Mielczarek
Pamela Krug
Maciej Mazur
Zdzisław CHILMONCZYK
Piotr Suchocki
Marta Bartel
Barbara Wysocka
Original Assignee
Narodowy Instytut Leków
Uniwersytet Warszawski
Warszawski Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Narodowy Instytut Leków, Uniwersytet Warszawski, Warszawski Uniwersytet Medyczny filed Critical Narodowy Instytut Leków
Priority to PL426879A priority Critical patent/PL238526B1/en
Priority to PCT/PL2019/050050 priority patent/WO2020050731A1/en
Priority to EP19857747.0A priority patent/EP3846790A4/en
Publication of PL426879A1 publication Critical patent/PL426879A1/en
Publication of PL238526B1 publication Critical patent/PL238526B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Przedmiotem zgłoszenia jest formulacja farmaceutyczna o właściwościach przeciwnowotworowych zawierająca co najmniej jeden izotiocyjanian oraz selol jako substancję wzmacniającą działanie izotiocyjanianu do zastosowania w leczeniu nowotworu, przy czym co najmniej jeden izotiocyjanian oraz selol umieszczone są w nośniku lipidowym.The subject of the application is a pharmaceutical formulation with antitumor properties containing at least one isothiocyanate and selol as an isothiocyanate enhancer for use in the treatment of cancer, wherein at least one isothiocyanate and selol are contained in a lipid carrier.

PL426879A 2018-09-04 2018-09-04 The combination of isothiocyanates with organic selenium compounds in drug carriers as a new pharmaceutical agent with anti-cancer activity PL238526B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL426879A PL238526B1 (en) 2018-09-04 2018-09-04 The combination of isothiocyanates with organic selenium compounds in drug carriers as a new pharmaceutical agent with anti-cancer activity
PCT/PL2019/050050 WO2020050731A1 (en) 2018-09-04 2019-09-03 Combination of isothiocyanates with organic selenium compounds encapsulated in drug carriers as new pharmaceutical agents with anti-tumor activity
EP19857747.0A EP3846790A4 (en) 2018-09-04 2019-09-03 COMBINATION OF ISOTHIOCYANATES WITH ORGANIC SELENIUM COMPOUNDS ENCAPSULATED IN DRUG VECTORS AS NEW PHARMACEUTICAL AGENTS WITH ANTITUMOR ACTIVITY

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426879A PL238526B1 (en) 2018-09-04 2018-09-04 The combination of isothiocyanates with organic selenium compounds in drug carriers as a new pharmaceutical agent with anti-cancer activity

Publications (2)

Publication Number Publication Date
PL426879A1 true PL426879A1 (en) 2020-03-09
PL238526B1 PL238526B1 (en) 2021-08-30

Family

ID=69709583

Family Applications (1)

Application Number Title Priority Date Filing Date
PL426879A PL238526B1 (en) 2018-09-04 2018-09-04 The combination of isothiocyanates with organic selenium compounds in drug carriers as a new pharmaceutical agent with anti-cancer activity

Country Status (3)

Country Link
EP (1) EP3846790A4 (en)
PL (1) PL238526B1 (en)
WO (1) WO2020050731A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL241189B1 (en) * 2018-09-27 2022-08-22 Narodowy Inst Lekow Pharmaceutical formulation containing selenitetrigliceride and cytostatic for use in cancer treatment
WO2021193835A1 (en) * 2020-03-25 2021-09-30 脳科学香料株式会社 Anti-inflammatory immunoenhancer
CN115944617B (en) * 2022-12-07 2025-02-11 浙江大学医学院附属儿童医院 Application of phenylethyl isothiocyanate naturally present in cruciferous vegetables as a drug against endometrial cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176530B1 (en) * 1994-06-29 1999-06-30 Bohdan Fitak Anticarcinogenous preparation and method of obtaining same
PL233619B1 (en) * 2013-01-30 2019-11-29 Piotr Roman Suchocki Preventive and therapeutic formulation and a method for its manufacture
PL229503B1 (en) * 2015-09-21 2018-07-31 Narodowy Inst Lekow Pharmaceutical formulation containing isocyanates and dexorubicin to be applied in treatment of tumours

Also Published As

Publication number Publication date
WO2020050731A1 (en) 2020-03-12
PL238526B1 (en) 2021-08-30
EP3846790A1 (en) 2021-07-14
EP3846790A4 (en) 2022-06-01

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