PL4271415T3 - Chemicznie związany transporter dopaminy do ośrodkowego układu nerwowego - Google Patents

Chemicznie związany transporter dopaminy do ośrodkowego układu nerwowego

Info

Publication number
PL4271415T3
PL4271415T3 PL22710718.2T PL22710718T PL4271415T3 PL 4271415 T3 PL4271415 T3 PL 4271415T3 PL 22710718 T PL22710718 T PL 22710718T PL 4271415 T3 PL4271415 T3 PL 4271415T3
Authority
PL
Poland
Prior art keywords
nervous system
central nervous
chemically bound
dopamine transporter
dopamine
Prior art date
Application number
PL22710718.2T
Other languages
English (en)
Inventor
Oscar José VARELA
Rosana Nieves CHEHÍN
Cesar Luis ÁVILA
Sergio Benjamín SOCÍAS
Diego PLOPER
Esteban VERA PINGITORE
Analía Silvina CHAVES
Martin LUONG
Verónica Elena MANZANO
Rodrigo Hernán TOMAS GRAU
Maria Florencia GONZÁLEZ LIZÁRRAGA
Adriana Andrea Kolender
Agustín Osvaldo PERNICONE
Original Assignee
Skybio Llc
Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet)
Universidad Nacional De Tucuman
Universidad De Buenos Aires
Sistema Provincial De Salud De Tucuman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skybio Llc, Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet), Universidad Nacional De Tucuman, Universidad De Buenos Aires, Sistema Provincial De Salud De Tucuman filed Critical Skybio Llc
Publication of PL4271415T3 publication Critical patent/PL4271415T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug one of the codrug's components being an antibiotic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL22710718.2T 2021-02-03 2022-02-02 Chemicznie związany transporter dopaminy do ośrodkowego układu nerwowego PL4271415T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163145190P 2021-02-03 2021-02-03
PCT/IB2022/050920 WO2022167954A1 (en) 2021-02-03 2022-02-02 Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system

Publications (1)

Publication Number Publication Date
PL4271415T3 true PL4271415T3 (pl) 2025-02-10

Family

ID=80780479

Family Applications (1)

Application Number Title Priority Date Filing Date
PL22710718.2T PL4271415T3 (pl) 2021-02-03 2022-02-02 Chemicznie związany transporter dopaminy do ośrodkowego układu nerwowego

Country Status (15)

Country Link
US (3) US11951170B2 (pl)
EP (1) EP4271415B1 (pl)
JP (1) JP7828354B2 (pl)
KR (1) KR20230154834A (pl)
CN (1) CN117597149A (pl)
AR (1) AR127596A1 (pl)
AU (1) AU2022215936A1 (pl)
BR (1) BR112023015520A2 (pl)
CA (1) CA3207324A1 (pl)
ES (1) ES2991798T3 (pl)
HU (1) HUE069118T2 (pl)
IL (1) IL304921A (pl)
MX (1) MX2023009105A (pl)
PL (1) PL4271415T3 (pl)
WO (1) WO2022167954A1 (pl)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
ES2272097T3 (es) * 1998-11-18 2007-04-16 Collagenex Pharmaceuticals, Inc. Nuevos derivados de 4-desdimetilaminotetraciclina.
WO2003030819A2 (en) * 2001-10-05 2003-04-17 Tetragenex Pharmaceuticals, Inc. Tetracycline derivatives and methods of use thereof
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003094842A2 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
WO2020084168A1 (en) * 2018-10-26 2020-04-30 Icm (Institut Du Cerveau Et De La Moelle Épinière) Tetracycline compound for treating drug-induced dyskinesia

Also Published As

Publication number Publication date
IL304921A (en) 2023-10-01
EP4271415C0 (en) 2024-07-03
JP2024505700A (ja) 2024-02-07
EP4271415A1 (en) 2023-11-08
ES2991798T3 (es) 2024-12-04
CA3207324A1 (en) 2022-08-11
JP7828354B2 (ja) 2026-03-11
US11951170B2 (en) 2024-04-09
KR20230154834A (ko) 2023-11-09
MX2023009105A (es) 2023-11-17
BR112023015520A2 (pt) 2023-10-24
US20260232814A1 (en) 2026-08-13
HUE069118T2 (hu) 2025-02-28
US12636371B2 (en) 2026-05-26
AR127596A1 (es) 2024-02-14
US20240197892A1 (en) 2024-06-20
CN117597149A (zh) 2024-02-23
US20230218768A1 (en) 2023-07-13
EP4271415B1 (en) 2024-07-03
AU2022215936A1 (en) 2023-08-24
WO2022167954A1 (en) 2022-08-11

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