PL4272834T3 - Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych - Google Patents
Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnychInfo
- Publication number
- PL4272834T3 PL4272834T3 PL23179249.0T PL23179249T PL4272834T3 PL 4272834 T3 PL4272834 T3 PL 4272834T3 PL 23179249 T PL23179249 T PL 23179249T PL 4272834 T3 PL4272834 T3 PL 4272834T3
- Authority
- PL
- Poland
- Prior art keywords
- mitochondria
- agents
- combined
- therapeutic use
- therapeutic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1896—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K51/0421—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
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- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
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- A—HUMAN NECESSITIES
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- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0883—Clinical applications for diagnosis of the heart
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662279489P | 2016-01-15 | 2016-01-15 | |
| US201662279442P | 2016-01-15 | 2016-01-15 | |
| US201662420381P | 2016-11-10 | 2016-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4272834T3 true PL4272834T3 (pl) | 2026-03-02 |
Family
ID=59311589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23179249.0T PL4272834T3 (pl) | 2016-01-15 | 2017-01-13 | Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10370458B2 (pl) |
| EP (4) | EP3735976A3 (pl) |
| JP (3) | JP7185527B2 (pl) |
| CN (1) | CN109152795A (pl) |
| AU (3) | AU2017208013B2 (pl) |
| CA (1) | CA3011472A1 (pl) |
| DK (1) | DK4272834T3 (pl) |
| ES (2) | ES2927427T3 (pl) |
| FI (1) | FI4272834T3 (pl) |
| PL (1) | PL4272834T3 (pl) |
| PT (1) | PT4272834T (pl) |
| SI (1) | SI4272834T1 (pl) |
| SM (1) | SMT202500457T1 (pl) |
| WO (1) | WO2017124037A1 (pl) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2741757B1 (en) | 2011-09-11 | 2018-05-16 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| US11491480B2 (en) | 2014-06-13 | 2022-11-08 | Children's Medical Center Corporation | Products and methods to isolate mitochondria |
| US11903974B2 (en) | 2015-11-30 | 2024-02-20 | Flagship Pioneering Innovations V, Inc. | Methods and compositions relating to chondrisomes from cultured cells |
| SI4272834T1 (sl) | 2016-01-15 | 2026-03-31 | Beth Israel Deaconess Medical Center, Inc. | Terapevtska uporaba mitohondrijev in kombiniranih mitohondrijskih sredstev |
| EP3549589A4 (en) * | 2016-11-30 | 2020-07-15 | Paean Biotechnology Inc. | PHARMACEUTICAL COMPOSITION CONTAINING MITOCHONDRIA |
| KR102275822B1 (ko) * | 2018-02-02 | 2021-07-12 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물 |
| WO2019186553A1 (en) * | 2018-03-27 | 2019-10-03 | Minovia Therapeutics Ltd. | Methods for elevation of lipid and cholesterol metabolism |
| KR102126199B1 (ko) * | 2018-04-26 | 2020-06-24 | 주식회사 파이안바이오테크놀로지 | 개질된 미토콘드리아 및 이의 용도 |
| US12551504B2 (en) | 2018-07-22 | 2026-02-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of pancreatic diseases |
| US12329781B2 (en) | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| JP2021531288A (ja) | 2018-07-22 | 2021-11-18 | ミノヴィア セラピューティクス リミテッド | 眼疾患のミトコンドリア増強療法 |
| WO2020021536A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| JP7458368B2 (ja) | 2018-07-22 | 2024-03-29 | ミノヴィア セラピューティクス リミテッド | 筋疾患のミトコンドリア増強療法 |
| JP7524157B2 (ja) | 2018-07-22 | 2024-07-29 | ミノヴィア セラピューティクス リミテッド | 脳疾患のミトコンドリア増強療法 |
| EP3837359A4 (en) * | 2018-08-14 | 2022-05-11 | Imel Biotherapeutics, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MITOCHONDRIAL DISEASES OR DISORDERS AND HETEROPLASMIA |
| US12268714B2 (en) | 2018-09-14 | 2025-04-08 | Luca Science Inc. | Transplantation of mitochondria into lymphoid organ and composition therefor |
| KR102128003B1 (ko) | 2018-10-31 | 2020-06-29 | 차의과학대학교 산학협력단 | 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물 |
| TWI706781B (zh) * | 2019-01-30 | 2020-10-11 | 台灣粒線體應用技術股份有限公司 | 用於治療多發性系統退化症之醫藥組合物 |
| JP7769545B2 (ja) * | 2019-02-15 | 2025-11-13 | チルドレンズ メディカル センター コーポレイション | 心不全の治療 |
| TWI706780B (zh) * | 2019-03-27 | 2020-10-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於製備治療阿茲海默症之醫藥組合物的用途 |
| US12508282B2 (en) | 2019-04-03 | 2025-12-30 | Mor Research Applications Ltd. | Mitochondrial transplantation and use thereof in ocular diseases |
| WO2020202103A1 (en) * | 2019-04-03 | 2020-10-08 | Mor Research Applications Ltd. | Mitochondrial transplantation and use thereof in ocular diseases |
| CN113905724A (zh) * | 2019-04-15 | 2022-01-07 | 儿童医学中心公司 | 包含线粒体的雾化组合物及其使用方法 |
| EP3964219A4 (en) * | 2019-04-29 | 2022-07-06 | Paean Biotechnology Inc. | Pharmaceutical composition for treating sepsis or systemic inflammatory response syndrome, comprising isolated mitochondria as active ingredient |
| EP3962365A4 (en) * | 2019-05-02 | 2023-02-01 | Children's Medical Center Corporation | PROPHYLACTIC AND THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIA |
| WO2020227682A1 (en) * | 2019-05-08 | 2020-11-12 | Children's Medical Center Corporation | Treating cancer |
| EP3986425A1 (en) * | 2019-06-18 | 2022-04-27 | United Therapeutics Corporation | Mitochondrial treatment of organs for transplantation |
| WO2021004477A1 (zh) * | 2019-07-09 | 2021-01-14 | 唐凌峰 | 一种基于线粒体的药物递送系统及其用途 |
| JP2022542495A (ja) * | 2019-07-24 | 2022-10-03 | ルカ・サイエンス株式会社 | 細胞からミトコンドリアを得る方法および得られたミトコンドリア |
| CN110643696B (zh) * | 2019-09-10 | 2022-08-19 | 青岛大学附属医院 | 一种肝移植术后肝脏缺血再灌注损伤预警检测试剂盒 |
| US12129521B2 (en) | 2019-10-24 | 2024-10-29 | Imel Biotherapeutics, Inc. | Methods for detection of macro-heteroplasmy and micro-heteroplasmy in mitochondrial DNA |
| US12150958B2 (en) | 2020-01-08 | 2024-11-26 | The Sallie Astor Burdine Breast Foundation | Compositions and methods for treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and associated methods for preparing said compositions |
| TWI789724B (zh) * | 2020-03-20 | 2023-01-11 | 台灣粒線體應用技術股份有限公司 | 粒線體用於治療及/或預防肌腱受損或其相關疾病之用途 |
| CN111249309B (zh) * | 2020-03-25 | 2022-08-23 | 复旦大学附属中山医院 | 一种治疗心肌缺血再灌注损伤的aldh2活化线粒体制剂及其制备方法和应用 |
| CA3172402A1 (en) | 2020-03-31 | 2021-10-07 | Minovia Therapeutics Ltd. | Mitochondria-enriched genetically engineered cells and uses thereof |
| CN116096861A (zh) * | 2020-04-03 | 2023-05-09 | 赛立维公司 | 过继性细胞转移的增强 |
| TW202233246A (zh) * | 2020-10-22 | 2022-09-01 | 南韓商白雁生物技術公司 | 含有抗癌劑之粒線體及其用途 |
| KR20220062716A (ko) * | 2020-11-09 | 2022-05-17 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 섬유증 예방 또는 치료용 약학 조성물 |
| US20250276116A1 (en) * | 2021-01-22 | 2025-09-04 | Tufts Medical Center, Inc. | Methods of mitigating myocardial damage due to extracorporeal membrane oxygenation |
| CN113444692A (zh) * | 2021-06-29 | 2021-09-28 | 上海交通大学医学院附属第九人民医院 | 一种重组心肌细胞及其用途 |
| US20240341299A1 (en) * | 2021-07-23 | 2024-10-17 | Paean Biotechnology Inc. | Composition for preservation of cells, tissues or organs, comprising isolated mitochondria, and use thereof |
| CA3258431A1 (en) * | 2022-06-10 | 2023-12-14 | Cellvie Ag | MITOCHONDRIA AS A TARGETED ADMINISTRATION PLATFORM |
| CA3257638A1 (en) | 2022-06-10 | 2023-12-14 | Cellvie Ag | COMPOSITION AND CRYOCONSERVATION PROCESS OF MITOCHONDRIA |
| WO2025064863A1 (en) * | 2023-09-20 | 2025-03-27 | The Children's Medical Center Corporation | Methods of vascular cell therapy and endothelial cell engraftment using mitochondria |
| WO2025070898A1 (ko) * | 2023-09-26 | 2025-04-03 | 차의과학대학교 산학협력단 | 분리된 미토콘드리아를 포함하는 통증 예방 또는 치료용 조성물 및 이의 용도 |
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