PL4272834T3 - Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych - Google Patents

Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych

Info

Publication number
PL4272834T3
PL4272834T3 PL23179249.0T PL23179249T PL4272834T3 PL 4272834 T3 PL4272834 T3 PL 4272834T3 PL 23179249 T PL23179249 T PL 23179249T PL 4272834 T3 PL4272834 T3 PL 4272834T3
Authority
PL
Poland
Prior art keywords
mitochondria
agents
combined
therapeutic use
therapeutic
Prior art date
Application number
PL23179249.0T
Other languages
English (en)
Inventor
James D. MCCULLY
Sidney LEVITSKY
Douglas B. COWAN
Sitaram M. Emani
Pedro J. Del Nido
Original Assignee
The Children's Medical Center Corporation
Beth Israel Deaconess Medical Center, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc. filed Critical The Children's Medical Center Corporation
Publication of PL4272834T3 publication Critical patent/PL4272834T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42Arrangements for detecting radiation specially adapted for radiation diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1896Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0412Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0421Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1203Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/503Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Clinical applications
    • A61B8/0883Clinical applications for diagnosis of the heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
PL23179249.0T 2016-01-15 2017-01-13 Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych PL4272834T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662279442P 2016-01-15 2016-01-15
US201662279489P 2016-01-15 2016-01-15
US201662420381P 2016-11-10 2016-11-10

Publications (1)

Publication Number Publication Date
PL4272834T3 true PL4272834T3 (pl) 2026-03-02

Family

ID=59311589

Family Applications (1)

Application Number Title Priority Date Filing Date
PL23179249.0T PL4272834T3 (pl) 2016-01-15 2017-01-13 Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych

Country Status (14)

Country Link
US (4) US10370458B2 (pl)
EP (4) EP3402490B1 (pl)
JP (3) JP7185527B2 (pl)
CN (1) CN109152795A (pl)
AU (3) AU2017208013B2 (pl)
CA (1) CA3011472A1 (pl)
DK (1) DK4272834T3 (pl)
ES (2) ES2927427T3 (pl)
FI (1) FI4272834T3 (pl)
PL (1) PL4272834T3 (pl)
PT (1) PT4272834T (pl)
SI (1) SI4272834T1 (pl)
SM (1) SMT202500457T1 (pl)
WO (1) WO2017124037A1 (pl)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL282198B2 (en) 2011-09-11 2025-11-01 Minovia Therapeutics Ltd Compositions of functional mitochondria and uses thereof
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
US11903974B2 (en) 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
JP2020502078A (ja) * 2016-11-30 2020-01-23 パイアン・バイオテクノロジー・インコーポレイテッドPaean Biotechnology Inc. ミトコンドリアを含む医薬組成物
EP3747449A4 (en) * 2018-02-02 2021-10-20 Paean Biotechnology Inc. PHARMACEUTICAL COMPOSITION WITH ISOLATED MITOCHONDRIA FOR THE PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS
EP3773639A4 (en) * 2018-03-27 2021-08-11 Minovia Therapeutics Ltd. LIPID AND CHOLESTEROL METABOLISM RAISING PROCESSES
WO2019209051A1 (ko) * 2018-04-26 2019-10-31 주식회사 파이안바이오테크놀로지 개질된 미토콘드리아 및 이의 용도
JP7586811B2 (ja) 2018-07-22 2024-11-19 ミノヴィア セラピューティクス リミテッド 腎臓疾患のミトコンドリア増強療法
EP3823644A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES
US11951135B2 (en) 2018-07-22 2024-04-09 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of muscle diseases
WO2020021535A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of ocular diseases
EP3823646A4 (en) 2018-07-22 2022-06-08 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of brain diseases
AU2019311859B2 (en) 2018-07-22 2025-12-18 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
US20200054682A1 (en) * 2018-08-14 2020-02-20 Imel Biotherapeutics, Inc. Methods and compositions for treating mitochondrial disease or disorders and heteroplasmy
CN112912087A (zh) * 2018-09-14 2021-06-04 卢卡科学株式会社 线粒体向淋巴器官中的移植以及用于该移植的组合物
US12514875B2 (en) 2018-10-31 2026-01-06 Humancellbio Co., Ltd. Pharmaceutical composition comprising isolated mitochondria for preventing or treating tendinopathy
TWI706781B (zh) * 2019-01-30 2020-10-11 台灣粒線體應用技術股份有限公司 用於治療多發性系統退化症之醫藥組合物
CA3130213A1 (en) 2019-02-15 2020-08-20 Children's Medical Center Corporation Treating heart failure
TWI706780B (zh) * 2019-03-27 2020-10-11 台灣粒線體應用技術股份有限公司 粒線體用於製備治療阿茲海默症之醫藥組合物的用途
US12508282B2 (en) 2019-04-03 2025-12-30 Mor Research Applications Ltd. Mitochondrial transplantation and use thereof in ocular diseases
US12478644B2 (en) 2019-04-03 2025-11-25 Mor Research Applications Ltd. Mitochondrial transplantation and use thereof in ocular diseases
EP3955902B1 (en) * 2019-04-15 2024-07-17 Children's Medical Center Corporation Aerosolized compositions comprising mitochondria and methods of use thereof
EP3964219A4 (en) * 2019-04-29 2022-07-06 Paean Biotechnology Inc. Pharmaceutical composition for treating sepsis or systemic inflammatory response syndrome, comprising isolated mitochondria as active ingredient
WO2020222866A1 (en) * 2019-05-02 2020-11-05 Children's Medical Center Corporation Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents
WO2020227682A1 (en) * 2019-05-08 2020-11-12 Children's Medical Center Corporation Treating cancer
WO2020257281A1 (en) * 2019-06-18 2020-12-24 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN114786685B (zh) * 2019-07-09 2025-05-06 唐凌峰 一种基于线粒体的药物递送系统及其用途
BR112022001207A2 (pt) * 2019-07-24 2022-03-15 Luca Science Inc Método de obtenção de mitocôndrias de células e mitocôndrias obtidas
CN110643696B (zh) * 2019-09-10 2022-08-19 青岛大学附属医院 一种肝移植术后肝脏缺血再灌注损伤预警检测试剂盒
JP7745544B2 (ja) 2019-10-24 2025-09-29 イメル バイオセラピューティクス,インク. ミトコンドリアdna中のマクロヘテロプラスミー及びミクロヘテロプラスミーを検出するための方法
US12150958B2 (en) 2020-01-08 2024-11-26 The Sallie Astor Burdine Breast Foundation Compositions and methods for treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and associated methods for preparing said compositions
TWI857807B (zh) * 2020-03-20 2024-10-01 台灣粒線體應用技術股份有限公司 含有粒線體之組合物及其用於作為皮膚纖維母細胞活性促進劑之用途
CN111249309B (zh) * 2020-03-25 2022-08-23 复旦大学附属中山医院 一种治疗心肌缺血再灌注损伤的aldh2活化线粒体制剂及其制备方法和应用
BR112022019609A2 (pt) 2020-03-31 2022-11-29 Minovia Therapeutics Ltd Células geneticamente modificadas enriquecidas com mitocôndrias e usos das mesmas
CN116096861A (zh) * 2020-04-03 2023-05-09 赛立维公司 过继性细胞转移的增强
WO2022086257A1 (ko) * 2020-10-22 2022-04-28 주식회사 파이안바이오테크놀로지 항암제를 포함한 미토콘드리아 및 이의 용도
KR20220062716A (ko) * 2020-11-09 2022-05-17 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 섬유증 예방 또는 치료용 약학 조성물
WO2022159756A1 (en) * 2021-01-22 2022-07-28 Tufts Medical Center, Inc. Methods of mitigating myocardial damage due to extracorporeal membrane oxygenation
CN113444692A (zh) * 2021-06-29 2021-09-28 上海交通大学医学院附属第九人民医院 一种重组心肌细胞及其用途
CN118042929A (zh) * 2021-07-23 2024-05-14 白雁生物技术公司 用于保存细胞、组织或器官的包含分离的线粒体的组合物及其应用
CN119486767A (zh) * 2022-06-10 2025-02-18 赛尔维股份公司 作为靶向递送平台的线粒体
CN119365073A (zh) 2022-06-10 2025-01-24 赛立维公司 用于冷冻保存线粒体的组合物和方法
WO2025064863A1 (en) * 2023-09-20 2025-03-27 The Children's Medical Center Corporation Methods of vascular cell therapy and endothelial cell engraftment using mitochondria
WO2025070898A1 (ko) * 2023-09-26 2025-04-03 차의과학대학교 산학협력단 분리된 미토콘드리아를 포함하는 통증 예방 또는 치료용 조성물 및 이의 용도
WO2025090754A1 (en) * 2023-10-24 2025-05-01 The General Hospital Corporation Mitochondrial transplantation for long-term tissue preservation
WO2025126112A1 (en) * 2023-12-12 2025-06-19 Cells For Cells S.A. Composition enriched in mitochondria isolated from umbilical cord mesenchymal stem cells, useful in osteoarthritis
WO2025184537A1 (en) * 2024-03-01 2025-09-04 The Board Of Trustees Of The Leland Stanford Junior University Bio-engineered mitochondria for targeted delivery to cells
WO2025199076A1 (en) * 2024-03-18 2025-09-25 The Board Of Trustees Of The Leland Stanford Junior University Methods for improving cardiac graft function

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2561043A (en) 1946-07-12 1951-07-17 Agrashell Inc Apparatus for grinding combustible materials
US2854143A (en) 1957-02-13 1958-09-30 Ohio Commw Eng Co Centrifugal stratifier with plural filter means
US3826255A (en) 1972-06-22 1974-07-30 Hudson Oxygen Therapy Sales Co Intermittent positive pressure breathing manifold
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
US4279890A (en) 1975-10-08 1981-07-21 Chattem, Inc. Cosmetic facial powder containing walnut shell flour
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
DE3151275C2 (de) 1981-12-24 1986-07-10 SKF GmbH, 8720 Schweinfurt Befestigungsvorrichtung für Werkzeuge
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
DE3711054A1 (de) 1987-04-02 1988-10-13 Socop Nahrungsmittel Biophysikalisch derivatisiertes hefepraeparat, verfahren zu dessen herstellung und dieses hefepraeparat enthaltende futtermittel und pflanzenwuchsstoffe
JPH087215B2 (ja) * 1987-08-24 1996-01-29 シュティフツング・フュア・ディアグノスティッシュ・フォルシュンク 抗原および/又は抗体の検出方法および検出用の試験キット
DE4038076A1 (de) 1990-11-29 1992-06-04 Stockhausen Chem Fab Gmbh Abrasivum in kosmetischen produkten und verfahren zur herstellung und verwendung desselben
DE4139664A1 (de) 1991-12-02 1993-06-03 Diagen Inst Molekularbio Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5286718A (en) * 1991-12-31 1994-02-15 Ribi Immunochem Research, Inc. Method and composition for ameliorating tissue damage due to ischemia and reperfusion
US6867197B1 (en) 1995-03-30 2005-03-15 Mitokor Method of targeting conjugate molecules to mitochondria
CN1187196A (zh) 1995-06-08 1998-07-08 普罗金工业有限公司 用于提取dna的方法和装置
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US20080275005A1 (en) * 1998-11-25 2008-11-06 Murphy Michael P Mitochondrially targeted antioxidants
CN1133568C (zh) 1999-01-18 2004-01-07 地球制药株式会社 气溶胶扩散喷雾器
US7097832B1 (en) * 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
US6562864B1 (en) * 1999-09-02 2003-05-13 Drake Larson Catechin multimers as therapeutic drug delivery agents
US20020046410A1 (en) 2000-09-06 2002-04-18 Robert Lanza Method for generating immune-compatible cells and tissues using nuclear transfer techniques
US6562563B1 (en) * 1999-11-03 2003-05-13 Mitokor Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
CN1253220C (zh) * 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
AU2002330938A1 (en) * 2001-07-31 2003-02-17 Northeastern University Mitochondrial genome replenishment
US6777227B2 (en) 2002-01-09 2004-08-17 John L. Ricci Bio-reactor and cell culture surface with microgeometric surfaces
CA2480790A1 (en) 2002-04-01 2003-10-16 Kazunori Murakami Use of antithrombin iii in treating acute lung injury
US20030199464A1 (en) * 2002-04-23 2003-10-23 Silviu Itescu Regeneration of endogenous myocardial tissue by induction of neovascularization
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
US20040171809A1 (en) 2002-09-09 2004-09-02 Korsmeyer Stanley J. BH3 peptides and method of use thereof
US7125434B2 (en) 2002-12-19 2006-10-24 Millipore Corporation Deep gradient-density filter device
EP1599216B9 (en) 2003-02-04 2015-02-11 Cornell Research Foundation, Inc. Methods for preventing mitochondrial permeability transition
EP1608411B1 (en) * 2003-04-01 2010-09-29 United States Government as represented by the Department of Veteran's Affaires Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure.
CN1832763A (zh) * 2003-06-05 2006-09-13 森特利昂公司 编码纤维母细胞生长因子的质粒用于治疗与高胆固醇血症或糖尿病相关的血管生成缺陷
CA2532228C (en) 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
EP1664316B1 (en) 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
CA2559955C (en) 2004-03-15 2016-02-16 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
CA2560415A1 (en) 2004-03-29 2005-10-13 The Procter & Gamble Company Aerosol
US8420377B2 (en) 2004-04-15 2013-04-16 Michael D. Koob Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using
JP4764426B2 (ja) 2004-06-07 2011-09-07 プロチバ バイオセラピューティクス インコーポレイティッド カチオン性脂質および使用方法
CA2569664C (en) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
WO2006080951A2 (en) 2004-07-01 2006-08-03 Yale University Targeted and high density drug loaded polymeric materials
US20080260637A1 (en) 2004-11-17 2008-10-23 Dalia Dickman Methods of Detecting Prostate Cancer
WO2006059329A1 (en) 2004-12-01 2006-06-08 Hadasit Medical Research Services & Development Limited Platelet-derived microparticles for therapy
CN101146826A (zh) * 2005-01-24 2008-03-19 得克萨斯大学体系董事会 与磷脂酰丝氨酸结合的fc融合构建体及其治疗用途
US7431222B2 (en) 2005-06-03 2008-10-07 Monterrosa Christopher H Aerosol spray masking device
WO2007011757A1 (en) 2005-07-14 2007-01-25 Myogen, Inc. Use of inhibitors of the ubiquitin proteasome pathway for increasing contractility of the heart
WO2007048046A2 (en) 2005-10-20 2007-04-26 Protiva Biotherapeutics, Inc. Sirna silencing of filovirus gene expression
CN101346393B (zh) 2005-11-02 2015-07-22 普洛体维生物治疗公司 修饰的siRNA分子及其应用
DE102005054628A1 (de) 2005-11-16 2007-05-24 Cevec Pharmaceuticals Gmbh Verfahren zur Herstellung von permanenten humanen Zelllinien
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
US9360473B2 (en) 2006-08-16 2016-06-07 Eutropics Pharmaceuticals, Inc. Assay system to identify therapeutic agents
US7923984B2 (en) * 2007-01-19 2011-04-12 The Regents Of The University Of Michigan Universal, wireless, nano-optical voltmeters
US9603872B2 (en) * 2007-05-02 2017-03-28 The McLeon Hospital Corporation Methods and compositions for mitochondrial replacement therapy
IL183818A0 (en) 2007-06-10 2007-10-31 Shimon Harpaz Uniformly abrasive confectionery product and process therefor
US20090202606A1 (en) 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
ES2560097T3 (es) * 2008-02-04 2016-02-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Procedimientos y composiciones de tratamiento de trastornos mitocondriales
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2010075116A2 (en) 2008-12-15 2010-07-01 Life Technologies Corporation Nucleic acid purification apparatus and method
KR101728655B1 (ko) 2008-12-18 2017-04-19 다이서나 파마수이티컬, 인크. 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
US20100249214A1 (en) 2009-02-11 2010-09-30 Dicerna Pharmaceuticals Multiplex dicer substrate rna interference molecules having joining sequences
JP5612279B2 (ja) * 2009-06-26 2014-10-22 日本合成化学工業株式会社 心筋梗塞非ヒト動物モデル及びその作製方法
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
EP2449106B1 (en) 2009-07-01 2015-04-08 Protiva Biotherapeutics Inc. Compositions and methods for silencing apolipoprotein b
WO2011019807A2 (en) * 2009-08-11 2011-02-17 The Johns Hopkins University Measurement of mitochondrial membrane potential to assess organ dysfunction
CN101693884B (zh) 2009-10-21 2012-05-23 宁夏中联达生物有限公司 一种从胎盘、脐带或脂肪组织中分离提取干细胞的方法
MX344460B (es) 2009-12-23 2016-12-14 Cytovera Inc * Sistema y método para la filtración de partículas.
US8903660B2 (en) 2010-06-24 2014-12-02 The Invention Science Fund I, Llc Rejuvenation or preservation of germ cells
US8658614B2 (en) * 2010-08-13 2014-02-25 The University of Texas Health Science Center Aptamer-containing compositions and methods for targeting E-selectin
US8846028B2 (en) * 2010-10-28 2014-09-30 The Invention Science Fund I, Llc Mitochondrial enhancement of cells
WO2012085833A1 (en) 2010-12-22 2012-06-28 Koninklijke Philips Electronics N.V. Nebulizer device
US20130022666A1 (en) 2011-07-20 2013-01-24 Anna Brzezinska Methods and compositions for transfer of mitochondria into mammalian cells
IL282198B2 (en) * 2011-09-11 2025-11-01 Minovia Therapeutics Ltd Compositions of functional mitochondria and uses thereof
US8648034B2 (en) * 2011-12-09 2014-02-11 Changhua Christian Hospital Method and applications of peptide-mediated mitochondrial delivery system
US8927268B2 (en) 2012-02-17 2015-01-06 Invent Biotechnologies, Inc. Rapid membrane isolation method for animal and plant samples
WO2013171752A1 (en) 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
KR102137450B1 (ko) * 2012-07-12 2020-07-27 콘드리온 아이피 비.브이. 미토콘드리아 질환을 치료하기 위한 크로마닐 유도체
US8895312B2 (en) * 2012-08-20 2014-11-25 The Regents Of The University Of California Nanofluidic platform for single mitochondria analysis
US20140106004A1 (en) * 2012-10-12 2014-04-17 Bing Lou Wong Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence
AU2013335451C1 (en) 2012-10-23 2024-07-04 Toolgen Incorporated Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
JP2016506391A (ja) 2012-12-06 2016-03-03 ステルス ペプチドズ インターナショナル インコーポレイテッド ペプチド治療薬およびその使用方法
IL239344B2 (en) 2012-12-12 2024-06-01 Broad Inst Inc Systems engineering, methods and optimal guiding components for sequence manipulation
WO2014093655A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
EP2840140B2 (en) 2012-12-12 2023-02-22 The Broad Institute, Inc. Crispr-Cas based method for mutation of prokaryotic cells
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
CN113355357B (zh) 2012-12-12 2024-12-03 布罗德研究所有限公司 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
WO2014113638A1 (en) 2013-01-17 2014-07-24 Aer Devices, Inc. Multi-use albuterol maintenance therapy formulations and devices therefor
CA2848895C (en) * 2013-04-15 2021-09-07 London Health Sciences Centre Research Inc. Treatment of compartment syndrome
US9781909B2 (en) * 2013-07-17 2017-10-10 University Of Manitoba Mito-Ob: a transgenic mouse model for obesity
WO2015073396A1 (en) 2013-11-12 2015-05-21 The Brigham And Women's Hospital, Inc. Growth differentiation factor (gdf) for treatment of diastolic heart failure
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
US9912376B2 (en) 2014-07-15 2018-03-06 Adtran, Inc. Managing crosstalk in vectored transmissions
JP6441472B2 (ja) * 2014-09-30 2018-12-19 台灣粒線體應用技術股▲扮▼有限公司Taiwan Mitochondrion Applied Technology Co.,Ltd. 活性成分として外因性ミトコンドリアを含む組成物、ならびにその使用およびそのための細胞修復法
JP6355220B2 (ja) 2014-12-31 2018-07-11 台灣粒線體應用技術股▲扮▼有限公司Taiwan Mitochondrion Applied Technology Co.,Ltd. 肺損傷を治療するための新規な医薬組成物及びその使用
IL299482B2 (en) 2015-02-26 2025-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched with active mitochondria
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US11903974B2 (en) 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
JP7218897B2 (ja) 2016-11-16 2023-02-07 ルカ・サイエンス株式会社 心不全の治療及び/又は予防に用いるための心筋幹細胞の製造方法
EP3773639A4 (en) 2018-03-27 2021-08-11 Minovia Therapeutics Ltd. LIPID AND CHOLESTEROL METABOLISM RAISING PROCESSES
CA3130213A1 (en) 2019-02-15 2020-08-20 Children's Medical Center Corporation Treating heart failure
EP3955902B1 (en) 2019-04-15 2024-07-17 Children's Medical Center Corporation Aerosolized compositions comprising mitochondria and methods of use thereof
WO2020222866A1 (en) * 2019-05-02 2020-11-05 Children's Medical Center Corporation Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents

Also Published As

Publication number Publication date
JP2024161552A (ja) 2024-11-19
EP3402490A4 (en) 2019-08-07
EP4272834B1 (en) 2025-09-03
SI4272834T1 (sl) 2026-03-31
ES3057779T3 (en) 2026-03-04
SMT202500457T1 (it) 2026-01-12
EP3735976A3 (en) 2021-01-27
JP2019507729A (ja) 2019-03-22
ES2927427T3 (es) 2022-11-04
FI4272834T3 (fi) 2025-12-05
JP7185527B2 (ja) 2022-12-07
AU2017208013A1 (en) 2018-08-09
AU2017208013B2 (en) 2022-12-01
EP4653048A3 (en) 2026-03-04
CA3011472A1 (en) 2017-07-20
EP4272834A3 (en) 2024-01-03
EP4653048A2 (en) 2025-11-26
PT4272834T (pt) 2025-12-10
WO2017124037A1 (en) 2017-07-20
AU2025202775A1 (en) 2025-05-08
US20230183380A1 (en) 2023-06-15
EP4272834A2 (en) 2023-11-08
CN109152795A (zh) 2019-01-04
US20200123273A1 (en) 2020-04-23
US20180057610A1 (en) 2018-03-01
EP3735976A2 (en) 2020-11-11
US20230416413A1 (en) 2023-12-28
AU2023201193B2 (en) 2025-01-23
AU2023201193A1 (en) 2023-04-06
EP3402490B1 (en) 2022-06-01
US12168700B2 (en) 2024-12-17
EP3402490A1 (en) 2018-11-21
JP7543378B2 (ja) 2024-09-02
DK4272834T3 (da) 2025-12-15
US10370458B2 (en) 2019-08-06
US12600800B2 (en) 2026-04-14
JP2023018100A (ja) 2023-02-07

Similar Documents

Publication Publication Date Title
PL4272834T3 (pl) Zastosowanie terapeutyczne mitochondriów i połączonych środków mitochondrialnych
IL293377B1 (en) Hsd17b13 variants and uses thereof
HRP20260160T1 (hr) Uporaba inhibitora miostatina i kombiniranih terapija
PT3694529T (pt) Proteínas triespecíficas e métodos de utilização
DK3641819T3 (da) Anvendelse af cannabidiol i behandling af tuberøst sklerosekompleks
IL262092A (en) Humanized anti-pacap antibodies and uses thereof
EP3526222A4 (en) TYK2 INHIBITORS AND THEIR USES
EP3528816A4 (en) TYK2 INHIBITORS AND USES THEREOF
IL263030A (en) Pegylated liposomes and methods of use
HRP20251095T1 (hr) Neoantigeni i metode njihove uporabe
HRP20260151T1 (hr) Modificirani polipeptidi i njihova uporaba
PT3548033T (pt) Compostos e respectivos métodos de utilização
IL263680A (en) Combination therapies
DK3411398T3 (da) Målrettede terapeutiske midler og anvendelse heraf
EP4212536C0 (en) BENZOXAZEPINE OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
PL3179991T3 (pl) Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2
MA41794A (fr) Agents thérapeutiques modifiés et compositions associées
IL283782A (en) Anellosomes and methods of use
PL4335517T3 (pl) Podawanie i dawkowanie diaminofenotiazyn
PL3512517T3 (pl) Stosowanie pridopidyny w leczeniu lęku i depresji
HUE071358T2 (hu) Benzolszulfonamid vegyületek és terápiás szerként való alkalmazásuk
EP3310376A4 (en) MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF
IL258997B (en) Honey-cannabinoid therapeutic composition
IL250173B (en) Actuation mechanism and associated methods
EP3334429C0 (en) HYPERPHENYLALANINEMIA AND TREATMENTS THEREFOR