PL428045A1 - Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie - Google Patents

Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie

Info

Publication number
PL428045A1
PL428045A1 PL428045A PL42804518A PL428045A1 PL 428045 A1 PL428045 A1 PL 428045A1 PL 428045 A PL428045 A PL 428045A PL 42804518 A PL42804518 A PL 42804518A PL 428045 A1 PL428045 A1 PL 428045A1
Authority
PL
Poland
Prior art keywords
vaccine
prevention
treatment
application
difficile
Prior art date
Application number
PL428045A
Other languages
English (en)
Inventor
Andrzej Myc
Agnieszka RAZIM
Sabina GÓRSKA
Andrzej Gamian
Original Assignee
Instytut Immunologii I Terapii Doświadczalnej Im. Ludwika Hirszfelda Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Immunologii I Terapii Doświadczalnej Im. Ludwika Hirszfelda Polskiej Akademii Nauk filed Critical Instytut Immunologii I Terapii Doświadczalnej Im. Ludwika Hirszfelda Polskiej Akademii Nauk
Priority to PL428045A priority Critical patent/PL428045A1/pl
Priority to US17/299,268 priority patent/US12194085B2/en
Priority to PCT/IB2019/060389 priority patent/WO2020115648A1/en
Priority to EP19829681.6A priority patent/EP3890774A1/en
Publication of PL428045A1 publication Critical patent/PL428045A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Przedmiotem wynalazku jest szczepionka weterynaryjna zawierająca nanoadiuwanty w postaci emulsji i antygeny Clostridium difficile oraz zastosowanie szczepionki do profilaktyki i leczenia zakażeń C.difficile, zwłaszcza u ptaków i ssaków. Przedmiotem wynalazku jest również zastosowanie szczepionki do wytwarzania przeciwciał swoistych wobec C. difficile.
PL428045A 2018-12-04 2018-12-04 Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie PL428045A1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL428045A PL428045A1 (pl) 2018-12-04 2018-12-04 Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie
US17/299,268 US12194085B2 (en) 2018-12-04 2019-12-03 Vaccine for the prevention and treatment of C. difficile infections and the use thereof
PCT/IB2019/060389 WO2020115648A1 (en) 2018-12-04 2019-12-03 Vaccine for the prevention and treatment of c. difficile infections and the use thereof
EP19829681.6A EP3890774A1 (en) 2018-12-04 2019-12-03 Vaccine for the prevention and treatment of c. difficile infections and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL428045A PL428045A1 (pl) 2018-12-04 2018-12-04 Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie

Publications (1)

Publication Number Publication Date
PL428045A1 true PL428045A1 (pl) 2020-06-15

Family

ID=69063828

Family Applications (1)

Application Number Title Priority Date Filing Date
PL428045A PL428045A1 (pl) 2018-12-04 2018-12-04 Szczepionka do profilaktyki i leczenia zakażeń C. difficile oraz jej zastosowanie

Country Status (4)

Country Link
US (1) US12194085B2 (pl)
EP (1) EP3890774A1 (pl)
PL (1) PL428045A1 (pl)
WO (1) WO2020115648A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114853895B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用
CN113717263B (zh) * 2021-08-04 2022-06-07 河北医科大学第二医院 一种艰难梭菌特异性抗原肽
CN120025411B (zh) * 2025-02-17 2025-11-28 贵州医科大学 一种基于艰难拟梭菌的细胞壁蛋白展示系统及其构建、应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9144606B2 (en) 2008-04-21 2015-09-29 Nanobio Corporation Nanoemulsion influenza vaccine
EP2349209A2 (en) * 2008-09-26 2011-08-03 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same

Also Published As

Publication number Publication date
US12194085B2 (en) 2025-01-14
WO2020115648A1 (en) 2020-06-11
US20220031826A1 (en) 2022-02-03
EP3890774A1 (en) 2021-10-13

Similar Documents

Publication Publication Date Title
SA520420801B1 (ar) أil جسام مضادة لـ -11
EA202190808A2 (ru) Составы антител к cd38 для подкожного введения и их применение
CO2020004838A2 (es) Dosis y administración de anticuerpos anti-c5 para el tratamiento de la hemoglobinuria paroxística nocturna (hpn) y el síndrome hemolítico urémico atípico (shua)
EA202092202A1 (ru) Конструкции антител к ror
EA201892294A1 (ru) Антитела и композиции против tim-3
EA202091130A1 (ru) Лиофилизованный препарат моноклонального антитела к транстиретину
MX389274B (es) Anticuerpo que neutraliza el virus respiratorio sincitial humano.
EA201892793A1 (ru) Анти-hla-g специфические антитела
EA201792590A1 (ru) КОНЪЮГАТ АНТИТЕЛА ПРОТИВ ErbB2 И ЛЕКАРСТВЕННОГО СРЕДСТВА И ЕГО КОМПОЗИЦИЯ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ
BR112016028816A8 (pt) combinação imunogênica, método para obter uma resposta imunológica específica, uso de uma combinação imunogênica, e, regime de vacinação para prevenção, redução ou tratamento de infecção por vírus sincicial respiratório
PH12020551710A1 (en) Anti-hla-g antibodies and use thereof
MX2022005253A (es) Anticuerpos neutralizantes de poliomavirus.
EA201791086A1 (ru) Человеческие антитела против гемагглютинина вируса гриппа
MX2017004975A (es) Composiciones de anticuerpos anti-il-7r.
MX2020011027A (es) Constructos de anticuerpos biespecíficos trivalentes.
EA201790239A1 (ru) Молекула-носитель для антигенов
EA201692201A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
EA201592203A1 (ru) Способы лечения таупатии
MX2023014154A (es) Anticuerpos anti-ccr8.
MX2020005555A (es) Construcciones inmunogenicas de peptidos de tau.
EA202190633A1 (ru) Лекарственные формы для применения в педиатрии, способы получения и применения
MX380557B (es) Anticuerpos específicos para cd38 para usarse en el tratamiento de mieloma múltiple (mm).
EA201990998A1 (ru) Фармацевтические составы и способы их получения
JO3565B1 (ar) الأجسام المضادة لشبيه الأنجيوبوييتين– 4 وطرق استخدامها
EA201992027A1 (ru) Водный состав антитела против pd-l1