PL429382A1 - Microparicles based on polylactide, polyglycolide or their copolymers - Google Patents
Microparicles based on polylactide, polyglycolide or their copolymersInfo
- Publication number
- PL429382A1 PL429382A1 PL429382A PL42938219A PL429382A1 PL 429382 A1 PL429382 A1 PL 429382A1 PL 429382 A PL429382 A PL 429382A PL 42938219 A PL42938219 A PL 42938219A PL 429382 A1 PL429382 A1 PL 429382A1
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- active substances
- polyglycolide
- polylactide
- copolymers
- Prior art date
Links
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 title abstract 2
- 229920000954 Polyglycolide Polymers 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 title abstract 2
- 229920000747 poly(lactic acid) Polymers 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 2
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 2
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 2
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 229960004588 cilostazol Drugs 0.000 abstract 1
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 abstract 1
- 229960005309 estradiol Drugs 0.000 abstract 1
- 229960003765 fluvastatin Drugs 0.000 abstract 1
- 229960004844 lovastatin Drugs 0.000 abstract 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
- 229960002797 pitavastatin Drugs 0.000 abstract 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229960002965 pravastatin Drugs 0.000 abstract 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są mikrocząstki na bazie polilaktydu, poliglikolidu lub ich kopolimerów, które mają kształt elipsoidalny o różnym stopniu wydłużenia korzystnie, gdy stosunek ich długości do szerokości wynosi około 2:1, przy czym jako substancje aktywne zawierają substancje o charakterze lipofilnym inkorporowane do polimeru w trakcie tworzenia. Mikrocząstki korzystnie jako substancje aktywne zawierają jako substancje aktywne zawierają substancje dobrze rozpuszczalne w dichlorometanie, a słabo rozpuszczalne w wodzie, a w szczególności stawny (inhibitory reduktazy 3-hydroksy-3-metyloglutarylo-koenzymu A (HMG-CoA)) jak: simwastatynę, lowastatynę, prawastatynę, fluwastatynę, pitawastatynę oraz atorwastatynę, cilostazol, 17ß-estradiol, inhibitory białek transportujących estry cholesterolu (cholesterol ester transfer protein (CETP) inhibitors), inhibitory metaloproteinaz.The subject of the application are microparticles based on polylactide, polyglycolide or their copolymers, which have an ellipsoidal shape with a different degree of elongation, preferably when the ratio of their length to width is about 2: 1, with the active substances containing lipophilic substances incorporated into the polymer during creating. As active substances, the microparticles preferably contain as active substances substances that are highly soluble in dichloromethane, and poorly soluble in water, and in particular agitated (3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors) such as: simvastatin, lovastatin, pravastatin, fluvastatin, pitavastatin and atorvastatin, cilostazol, 17β-estradiol, inhibitors of cholesterol ester transfer proteins (CETP) inhibitors, metalloproteinase inhibitors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL429382A PL241266B1 (en) | 2019-03-25 | 2019-03-25 | Use of microparticles based on polylactide, polyglycolide or their copolymers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL429382A PL241266B1 (en) | 2019-03-25 | 2019-03-25 | Use of microparticles based on polylactide, polyglycolide or their copolymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL429382A1 true PL429382A1 (en) | 2020-10-05 |
| PL241266B1 PL241266B1 (en) | 2022-08-29 |
Family
ID=72669294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL429382A PL241266B1 (en) | 2019-03-25 | 2019-03-25 | Use of microparticles based on polylactide, polyglycolide or their copolymers |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL241266B1 (en) |
-
2019
- 2019-03-25 PL PL429382A patent/PL241266B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL241266B1 (en) | 2022-08-29 |
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