PL429857A1 - Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych oraz sposób prowadzenia badań w magnetycznym urządzeniu mikrofluidalnym - Google Patents

Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych oraz sposób prowadzenia badań w magnetycznym urządzeniu mikrofluidalnym

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Publication number
PL429857A1
PL429857A1 PL429857A PL42985719A PL429857A1 PL 429857 A1 PL429857 A1 PL 429857A1 PL 429857 A PL429857 A PL 429857A PL 42985719 A PL42985719 A PL 42985719A PL 429857 A1 PL429857 A1 PL 429857A1
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PL
Poland
Prior art keywords
chip
magnetic
microfluidic device
generator
chambers
Prior art date
Application number
PL429857A
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English (en)
Other versions
PL242812B1 (pl
Inventor
Roman SZAFRAN
Kazimierz GĄSIOROWSKI
Benita WIATRAK
Original Assignee
Politechnika Wrocławska
Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Politechnika Wrocławska, Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu filed Critical Politechnika Wrocławska
Priority to PL429857A priority Critical patent/PL242812B1/pl
Priority to PCT/PL2019/050075 priority patent/WO2020226519A1/en
Publication of PL429857A1 publication Critical patent/PL429857A1/pl
Publication of PL242812B1 publication Critical patent/PL242812B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/06—Magnetic means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Przedmiotem wynalazku jest magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych składające się z wieka, podstawy, osłon zbiorników oraz warstwy funkcjonalnej czipa, a wieko czipa zawiera zbiorniki zasilające oraz podziałkę milimetrową, a warstwa funkcjonalna czipa zawiera komory hodowlane, charakteryzujące się tym, że składa się z transparentnego dla światła widzialnego i UV czipa mikrofluidalnego (1) wyposażonego w co najmniej trzy liniowe komory hodowlane, z których każda łączy się na końcach ze zbiornikami zasilającymi elastyczną podstawę oraz z generatora mikropola magnetycznego (1) złożonego z platformy zawierającej gniazdo czipa, podpór dystansowych, zespołu podstawy generatora złożonego z wierzchu i spodu, zawierającej gniazdo magnesu, magnesu stałego oraz szeregu trzpieni ferromagnetycznych, przy czym układ komór hodowlanych w czipie mikrofluidalnym (2) oraz układ trzpieni ferromagnetycznych generatora mikropola magnetycznego (1) jest wzajemnie skorelowany w ten sposób, że trzpienie ferromagnetyczne w platformie przebiegają wzajemnie równolegle od powierzchni komór hodowlanych czipa do górnej powierzchni magnesu stałego. Przedmiotem wynalazku jest również sposób prowadzenia badań w magnetycznym urządzeniu mikrofluidalnym.
PL429857A 2019-05-07 2019-05-07 Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych PL242812B1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL429857A PL242812B1 (pl) 2019-05-07 2019-05-07 Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych
PCT/PL2019/050075 WO2020226519A1 (en) 2019-05-07 2019-12-06 Magnetic microfluidic device for high-throughput screening

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL429857A PL242812B1 (pl) 2019-05-07 2019-05-07 Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych

Publications (2)

Publication Number Publication Date
PL429857A1 true PL429857A1 (pl) 2020-11-16
PL242812B1 PL242812B1 (pl) 2023-05-02

Family

ID=69375983

Family Applications (1)

Application Number Title Priority Date Filing Date
PL429857A PL242812B1 (pl) 2019-05-07 2019-05-07 Magnetyczne urządzenie mikrofluidalne do szybkich badań przesiewowych

Country Status (2)

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PL (1) PL242812B1 (pl)
WO (1) WO2020226519A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113717847A (zh) * 2021-08-20 2021-11-30 西北工业大学深圳研究院 高通量藻菌微生物磁筛选装置和方法
JP7842545B2 (ja) * 2021-09-27 2026-04-08 東洋製罐グループホールディングス株式会社 マイクロ流体デバイス、及びマイクロ流体デバイスの使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
JP5889523B2 (ja) * 2010-09-21 2016-03-22 国立大学法人大阪大学 スフェロイド作製装置およびスフェロイド作製方法
PL237365B1 (pl) * 2016-12-09 2021-04-06 Politechnika Wroclawska Urządzenie mikrofluidalne do prowadzenia hodowli komórek w gradiencie substancji bioaktywnej

Also Published As

Publication number Publication date
PL242812B1 (pl) 2023-05-02
WO2020226519A1 (en) 2020-11-12

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