PL431178A1 - 2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone - Google Patents

2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone

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Publication number
PL431178A1
PL431178A1 PL431178A PL43117819A PL431178A1 PL 431178 A1 PL431178 A1 PL 431178A1 PL 431178 A PL431178 A PL 431178A PL 43117819 A PL43117819 A PL 43117819A PL 431178 A1 PL431178 A1 PL 431178A1
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Poland
Prior art keywords
methylglucopyranosyl
flavone
chloro
formula
hours
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PL431178A
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Polish (pl)
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PL239562B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL431178A priority Critical patent/PL239562B1/en
Publication of PL431178A1 publication Critical patent/PL431178A1/en
Publication of PL239562B1 publication Critical patent/PL239562B1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 2'-chloro-8-O-ß-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2. Przedmiotem zgłoszenia jest też sposób wytwarzania 2'-chloro-8-O-ß-D-(4"-O-metyloglukopiranozylo)-flawonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Beauveria bassiana KCH J 1.5, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 2'-chloroflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 2'-chloro-8-O-ß-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2, znajduje się we frakcji o pośredniej polarności, w czwartym paśmie od linii startu.The subject of the application is 2'-chloro-8-O-ß-D- (4 "-O-methylglucopyranosyl) -flavone of the formula 2. The subject of the application is also a process for the preparation of 2'-chloro-8-O-ß-D- ( 4 "-O-methylglucopyranosyl) -flavone characterized in that the Beauveria bassiana KCH J 1.5 strain is introduced into a medium suitable for filamentous fungi, then, after at least 72 hours, the substrate is introduced into the culture, which is 2'-chloroflavone of the formula 1, dissolved in a water-miscible organic solvent, the transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, then the product is extracted with a water-immiscible organic solvent and purified by chromatography, 2 ' -chloro-8-O-ß-D- (4 "-O-methylglucopyranosyl) -flavone of formula 2 is found in the intermediate polarity fraction in the fourth band from the starting line.

PL431178A 2019-09-16 2019-09-16 2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone PL239562B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL431178A PL239562B1 (en) 2019-09-16 2019-09-16 2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431178A PL239562B1 (en) 2019-09-16 2019-09-16 2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone

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PL431178A1 true PL431178A1 (en) 2021-03-22
PL239562B1 PL239562B1 (en) 2021-12-13

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PL431178A PL239562B1 (en) 2019-09-16 2019-09-16 2'-Chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 2'-chloro-8-O-β-D-(4"-O-methylglucopyranosyl)-flavone

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL451070A1 (en) * 2025-01-28 2026-08-03 Uniwersytet Przyrodniczy we Wrocławiu 2'-Chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for producing 2'-chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone
PL451071A1 (en) * 2025-01-28 2026-08-03 Uniwersytet Przyrodniczy we Wrocławiu 3'-Chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for producing 3'-chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone
PL451072A1 (en) * 2025-01-28 2026-08-03 Uniwersytet Przyrodniczy we Wrocławiu 4'-Chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone and method for producing 4'-chloro-6-O-β-D-(4''-O-methylglucopyranosyl)-flavanone

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PL239562B1 (en) 2021-12-13

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