PL433194A1 - Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells - Google Patents
Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cellsInfo
- Publication number
- PL433194A1 PL433194A1 PL433194A PL43319420A PL433194A1 PL 433194 A1 PL433194 A1 PL 433194A1 PL 433194 A PL433194 A PL 433194A PL 43319420 A PL43319420 A PL 43319420A PL 433194 A1 PL433194 A1 PL 433194A1
- Authority
- PL
- Poland
- Prior art keywords
- aqueous solution
- scaffolds
- injection
- intended
- chitosan
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 5
- 239000000499 gel Substances 0.000 title abstract 3
- 230000036760 body temperature Effects 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title abstract 2
- 239000007924 injection Substances 0.000 title abstract 2
- 210000002569 neuron Anatomy 0.000 title abstract 2
- 238000009395 breeding Methods 0.000 title 1
- 230000001488 breeding effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 abstract 5
- 239000002773 nucleotide Substances 0.000 abstract 3
- INTPYBRGLGSMRA-WFIJOQBCSA-L disodium cytidine 5'-monophosphate Chemical compound [Na+].[Na+].O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])([O-])=O)O1 INTPYBRGLGSMRA-WFIJOQBCSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 nucleotide disodium salt Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 abstract 1
- 230000006196 deacetylation Effects 0.000 abstract 1
- 238000003381 deacetylation reaction Methods 0.000 abstract 1
- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 abstract 1
- 229910021389 graphene Inorganic materials 0.000 abstract 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 abstract 1
- 235000019136 lipoic acid Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 229960002663 thioctic acid Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania żeli chitozanowych, formujących się w temperaturze ciała ludzkiego, przeznaczonych na rusztowania iniekcyjne do hodowli komórek nerwowych, polega na wprowadzeniu do schłodzonego roztworu wodnego soli chitozanu sporządzonej z chitozanu o stopniu deacetylacji 75-90% i o masie cząsteczkowej 500000-700000, najpierw środka wspomagające regenerację nerwów, jak kobalamina, kwas liponowy lub tlenek grafenu, a następnie kroplami schłodzonego roztworu wodnego soli disodowej nukleotydu, zmieszaniu składników i odpowietrzeniu otrzymanej w postaci zolu mieszaniny roztworu soli chitozanu z roztworem nukleotydu, wykazującej zdolność przejścia w postać żelu w temperaturze ciała ludzkiego, przy czym jako roztwór wodny soli disodowej nukleotydu stosuje się roztwór wodny soli disodowej 5'-monofosforanu cytydyny lub roztwór wodny mieszaniny soli disodowej 5'-monofosforanu cytydyny z solą disodową 5'-monofosforanu urydyny.The subject of the application is a method of producing chitosan gels, formed at the temperature of the human body, intended for injection scaffolds for the cultivation of nerve cells, consisting in introducing into a cooled aqueous solution of chitosan salt made of chitosan with a deacetylation degree of 75-90% and a molecular weight of 500,000-700,000, first nerve regeneration agents, such as cobalamin, lipoic acid or graphene oxide, and then with drops of a cooled aqueous solution of the nucleotide disodium salt, mixing the components and deaeration of the sol-obtained mixture of chitosan salt solution with the nucleotide solution, showing the ability to gel at body temperature human, wherein the aqueous solution of the nucleotide disodium salt is an aqueous solution of cytidine 5'-monophosphate disodium or an aqueous solution of a mixture of cytidine 5'-monophosphate disodium salt with uridine 5'-monophosphate disodium salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL433194A PL243349B1 (en) | 2020-03-11 | 2020-03-11 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL433194A PL243349B1 (en) | 2020-03-11 | 2020-03-11 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL433194A1 true PL433194A1 (en) | 2021-09-13 |
| PL243349B1 PL243349B1 (en) | 2023-08-07 |
Family
ID=77662660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL433194A PL243349B1 (en) | 2020-03-11 | 2020-03-11 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL243349B1 (en) |
-
2020
- 2020-03-11 PL PL433194A patent/PL243349B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL243349B1 (en) | 2023-08-07 |
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