PL439461A1 - Flow cell for testing the behavior of a pharmaceutical form, a system containing it and method for homogenizing a measuring fluid - Google Patents

Flow cell for testing the behavior of a pharmaceutical form, a system containing it and method for homogenizing a measuring fluid Download PDF

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Publication number
PL439461A1
PL439461A1 PL439461A PL43946121A PL439461A1 PL 439461 A1 PL439461 A1 PL 439461A1 PL 439461 A PL439461 A PL 439461A PL 43946121 A PL43946121 A PL 43946121A PL 439461 A1 PL439461 A1 PL 439461A1
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PL
Poland
Prior art keywords
flow cell
pharmaceutical form
testing
space
behavior
Prior art date
Application number
PL439461A
Other languages
Polish (pl)
Other versions
PL243897B1 (en
Inventor
Marcela Staniszewska
Bartosz Kołodziej
Jadwiga Paszkowska
Justyna Dobosz
Grzegorz Garbacz
Grzegorz Banach
Original Assignee
Physiolution Polska Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Physiolution Polska Spółka Z Ograniczoną Odpowiedzialnością filed Critical Physiolution Polska Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL439461A priority Critical patent/PL243897B1/en
Publication of PL439461A1 publication Critical patent/PL439461A1/en
Publication of PL243897B1 publication Critical patent/PL243897B1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Flexible containers without fluid transport within
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measuring Volume Flow (AREA)

Abstract

Przedmiotem zgłoszenia jest komora przepływowa (100) do badania zachowania postaci farmaceutycznej, a zwłaszcza jej konstrukcja umożliwiająca homogenizację zawartości komory przepływowej (100). Ponadto przedmiotem zgłoszenia jest również układ zawierający komorę przepływową (100), a także sposób homogenizacji płynu pomiarowego, poprzez środki zapewnione przez komorę przepływową (100) i układ zawierający tę komorę przepływową (100). Komora przepływowa (100) do badania zachowania postaci farmaceutycznej zawiera zewnętrzną ścianę boczną (110) i wewnętrzną ścianę boczną (120), które są oddzielone przestrzenią międzyścienną (130), dno (140) zaopatrzone w otwór dopływowy (141) i pokrywę (150) zaopatrzoną w co najmniej jeden otwór odpływowy (151), przy czym wewnętrzna ściana boczna (120), dno (140) i pokrywa (150) wyznaczają przestrzeń pomiarową (160) przeznaczoną do wprowadzenia płynu pomiarowego i postaci farmaceutycznej. Komora przepływowa (100), charakteryzuje się tym, że pokrywa (150) jest ukształtowana tak, że ujście (152) otworu odpływowego (151) od strony przestrzeni pomiarowej (160) znajduje się poniżej punktu szczytowego (161) przestrzeni pomiarowej (160), wewnętrzna ściana boczna (120) jest elastyczna i zewnętrzna ściana boczna (110) wyposażona jest w co najmniej jeden otwór doprowadzający (111) przeznaczony do doprowadzania płynu ciśnieniowego do przestrzeni międzyściennej (130) i wywierania ciśnienia na płyn pomiarowy oraz postać farmaceutyczną poprzez deformację wewnętrznej ściany bocznej (120).The subject of the application is a flow cell (100) for testing the behavior of a pharmaceutical form, and in particular its design enabling homogenization of the contents of the flow cell (100). In addition, the application also relates to a system comprising a flow cell (100) and a method for homogenizing a measuring fluid, by means provided by the flow cell (100) and a system comprising the flow cell (100). The flow cell (100) for testing pharmaceutical form behavior comprises an outer sidewall (110) and an inner sidewall (120) which are separated by an interstitial space (130), a bottom (140) provided with an inlet port (141) and a lid (150) provided with at least one drain hole (151), the inner side wall (120), the bottom (140) and the lid (150) defining a measuring space (160) for introducing the measuring fluid and the pharmaceutical form. The flow cell (100) is characterized in that the cover (150) is shaped so that the mouth (152) of the drain hole (151) on the side of the measurement space (160) is below the top point (161) of the measurement space (160), the inner sidewall (120) is flexible and the outer sidewall (110) is provided with at least one delivery port (111) for feeding pressurized fluid into the interwall space (130) and applying pressure to the measurement fluid and the pharmaceutical form by deforming the inner wall (120).

PL439461A 2021-11-08 2021-11-08 A flow chamber for testing the behavior of a pharmaceutical form, a system containing it and a method for homogenizing the measuring fluid PL243897B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439461A PL243897B1 (en) 2021-11-08 2021-11-08 A flow chamber for testing the behavior of a pharmaceutical form, a system containing it and a method for homogenizing the measuring fluid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439461A PL243897B1 (en) 2021-11-08 2021-11-08 A flow chamber for testing the behavior of a pharmaceutical form, a system containing it and a method for homogenizing the measuring fluid

Publications (2)

Publication Number Publication Date
PL439461A1 true PL439461A1 (en) 2023-05-15
PL243897B1 PL243897B1 (en) 2023-10-30

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ID=86325356

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439461A PL243897B1 (en) 2021-11-08 2021-11-08 A flow chamber for testing the behavior of a pharmaceutical form, a system containing it and a method for homogenizing the measuring fluid

Country Status (1)

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PL (1) PL243897B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL444690A1 (en) * 2023-04-28 2024-11-04 Physiolution Polska Spółka Z Ograniczoną Odpowiedzialnością Device for placing a pharmaceutical form of a drug

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL444690A1 (en) * 2023-04-28 2024-11-04 Physiolution Polska Spółka Z Ograniczoną Odpowiedzialnością Device for placing a pharmaceutical form of a drug

Also Published As

Publication number Publication date
PL243897B1 (en) 2023-10-30

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