PL439494A1 - Sposób otrzymywania ceramiczno-polimerowego kompozytu - Google Patents
Sposób otrzymywania ceramiczno-polimerowego kompozytuInfo
- Publication number
- PL439494A1 PL439494A1 PL439494A PL43949421A PL439494A1 PL 439494 A1 PL439494 A1 PL 439494A1 PL 439494 A PL439494 A PL 439494A PL 43949421 A PL43949421 A PL 43949421A PL 439494 A1 PL439494 A1 PL 439494A1
- Authority
- PL
- Poland
- Prior art keywords
- weight
- composite
- amount
- ceramic
- bone
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title abstract 5
- 229920000642 polymer Polymers 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 239000003431 cross linking reagent Substances 0.000 abstract 2
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 108060008539 Transglutaminase Proteins 0.000 abstract 1
- 239000003462 bioceramic Substances 0.000 abstract 1
- 239000005312 bioglass Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000002639 bone cement Substances 0.000 abstract 1
- 239000000316 bone substitute Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 102000003601 transglutaminase Human genes 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
- A61L24/0063—Phosphorus containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Materials Engineering (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Composite Materials (AREA)
- Ceramic Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania kompozytu ceramiczno-polimerowego jako substytu kości lub jako materiału wiążącego implant z kością, zwłaszcza jako kleju kostnego, charakteryzujący się tym, że do wody, korzystnie demineralizowanej, w ilości 37 do 47% wag. względem masy całego kompozytu w temperaturze od 40 do 60°C i przy szybkości mieszania od 150 do 300 rpm dodaje się polimer pochodzenia naturalnego, korzystnie żelatynę, w ilości od 17 do 19% wag. względem masy całego kompozytu, a następnie przy ciągłym mieszaniu do wodnego roztworu polimeru pochodzenia naturalnego w temperaturze od 30 do 50°C dodaje materiały bioceramiczne na bazie bioszkła i/lub hydroksyapatytu i/lub nanohydroksyapatytu w ilości od 35 do 38% wag. względem masy całego kompozytu. Uzyskaną kompozycję poddaje się homogenizacji i kolejno do mieszaniny dozuje się czynnik sieciujący, korzystnie transglutaminazę. Po dodaniu czynnika sieciującego mieszaninę poddaje się homogenizacji przez okres od 5 do 30 sekund, korzystnie 10 sekund.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL439494A PL247432B1 (pl) | 2021-11-14 | 2021-11-14 | Sposób otrzymywania ceramiczno-polimerowego kompozytu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL439494A PL247432B1 (pl) | 2021-11-14 | 2021-11-14 | Sposób otrzymywania ceramiczno-polimerowego kompozytu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL439494A1 true PL439494A1 (pl) | 2023-05-15 |
| PL247432B1 PL247432B1 (pl) | 2025-06-30 |
Family
ID=86325411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL439494A PL247432B1 (pl) | 2021-11-14 | 2021-11-14 | Sposób otrzymywania ceramiczno-polimerowego kompozytu |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL247432B1 (pl) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL449979A1 (pl) * | 2024-10-08 | 2026-04-13 | Politechnika Gdańska | Sposób otrzymywania kompozytowego, utwardzalnego substytutu tkanki kostnej z ochroną antybakteryjną |
-
2021
- 2021-11-14 PL PL439494A patent/PL247432B1/pl unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL449979A1 (pl) * | 2024-10-08 | 2026-04-13 | Politechnika Gdańska | Sposób otrzymywania kompozytowego, utwardzalnego substytutu tkanki kostnej z ochroną antybakteryjną |
Also Published As
| Publication number | Publication date |
|---|---|
| PL247432B1 (pl) | 2025-06-30 |
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