PL440647A1 - Sposób wytwarzania 1-(N-acyloamino)alkilideno-1,1-bisfosfonianów tetraetylu - Google Patents
Sposób wytwarzania 1-(N-acyloamino)alkilideno-1,1-bisfosfonianów tetraetyluInfo
- Publication number
- PL440647A1 PL440647A1 PL440647A PL44064722A PL440647A1 PL 440647 A1 PL440647 A1 PL 440647A1 PL 440647 A PL440647 A PL 440647A PL 44064722 A PL44064722 A PL 44064722A PL 440647 A1 PL440647 A1 PL 440647A1
- Authority
- PL
- Poland
- Prior art keywords
- sub
- sup
- acylamino
- bisphosphonates
- tetraethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229940122361 Bisphosphonate Drugs 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 abstract 1
- -1 triphenylphosphonium tetrafluoroborate Chemical compound 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania 1-(N-acyloamino)alkideno-1,1-bisfosfonianów tetraetylu o wzorze 1, w którym R<sup>1</sup> = Me, Et, Pr, i-Pr, Bu, i-Bu, Bn, Ph, MeOCH<sub>2</sub>C<sub>6</sub>H<sub>4</sub>; R<sup>2</sup> = BnO, Me, t-Bu. Sposób polega na tym, że do 1-(N-acyloamino)-1-alkoksyalkanofosfonianów dietylu o wzorze ogólnym 2, w którym R<sup>1</sup> = Me, Et, Pr, i-Pr, Bu, i-Bu, Bn, Ph, MeOCH<sub>2</sub>C<sub>6</sub>H<sub>4</sub>; R<sup>2</sup> = Bno, Me, t-Bu dodaje się tetrafluoroboran trifenylofosfoniowy Ph<sub>3</sub>P•HBF<sub>4</sub> w stosunku molowym od 1:1,05 do 1:1,12, korzystnie 1:1,08 oraz nukleofilowy fosforyn trietylu w stosunku molowym od 1:1,2 do 1:1,5, korzystnie 1:1,5, proces prowadzi się w temperaturze 15°C – 60°C, w czasie od 5 h do 24 h, w obecności rozpuszczalników organicznych, otrzymany surowy produkt oczyszcza się klasycznymi metodami chemicznymi, a ekstrakt poddaje się chromatografii kolumnowej, stosując jako eluent układ dichlorometan/metanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440647A PL244482B1 (pl) | 2022-03-14 | 2022-03-14 | Sposób wytwarzania 1-(N-acyloamino)alkilideno-1,1-bisfosfonianów tetraetylu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440647A PL244482B1 (pl) | 2022-03-14 | 2022-03-14 | Sposób wytwarzania 1-(N-acyloamino)alkilideno-1,1-bisfosfonianów tetraetylu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL440647A1 true PL440647A1 (pl) | 2023-09-18 |
| PL244482B1 PL244482B1 (pl) | 2024-01-29 |
Family
ID=88203711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL440647A PL244482B1 (pl) | 2022-03-14 | 2022-03-14 | Sposób wytwarzania 1-(N-acyloamino)alkilideno-1,1-bisfosfonianów tetraetylu |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL244482B1 (pl) |
-
2022
- 2022-03-14 PL PL440647A patent/PL244482B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL244482B1 (pl) | 2024-01-29 |
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