PL440810A1 - Bioink, method of its production and application for 3D bioprinting of the meniscus - Google Patents
Bioink, method of its production and application for 3D bioprinting of the meniscusInfo
- Publication number
- PL440810A1 PL440810A1 PL440810A PL44081022A PL440810A1 PL 440810 A1 PL440810 A1 PL 440810A1 PL 440810 A PL440810 A PL 440810A PL 44081022 A PL44081022 A PL 44081022A PL 440810 A1 PL440810 A1 PL 440810A1
- Authority
- PL
- Poland
- Prior art keywords
- bioink
- cme
- cnc
- gelatin
- production
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3872—Meniscus for implantation between the natural bone surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest biotusz, sposób jego wytwarzania oraz zastosowanie do biodruku 3D łąkotki. Biotusz charakteryzuje się tym, że stanowią go składniki o stężeniu: 0,75% [m/V] alginianu sodu, 4,0% [m/V] żelatyny i 1,4% [m/V] CMe-CNC rozpuszczane w sterylnym 4,6% [m/V] D-mannitolu oraz dodatek 6,0% [m/V] kolagen lub 0,1% [m/V] kwas hialuronowy. Sposób jego wytwarzania polega na tym, że komponent biotuszu w formie proszku w ilości na 10 ml biotuszu: 0,075 g alginianu sodu; 0,4 g żelatyny i 0,14 g CMe-CNC poddaje się 30 minutowej sterylizacji światłem UV, następnie składniki rozpuszcza się w 10 ml sterylnym 4,6% D-mannitolu w kolejności: alginian, żelatyna i CMe-CNC oraz dodatki kolagenu albo kwasu hialuronowego, po czym po każdym dodaniu składnika, biotusz wytrząsa się w znany sposób przy 700 rpm przez korzystnie 30 minut w temperaturze korzystnie 37°C, po czym tak przygotowany biotusz pozostawia się do dokładnego wymieszania komponentów przez co najmniej 12 godzin, dalej schładza się do temperatury 25°C.The subject of the application is the bioink, its production method and the use of meniscus 3D bioprinting. The bioink is characterized by the following ingredients: 0.75% [m/V] sodium alginate, 4.0% [m/V] gelatin and 1.4% [m/V] CMe-CNC dissolved in sterile 4.6% [m/V] D-mannitol and the addition of 6.0% [m/V] collagen or 0.1% [m/V] hyaluronic acid. The method of its production is as follows: the bioink component in powder form per 10 ml of bioink: 0.075 g of sodium alginate; 0.4 g of gelatin and 0.14 g of CMe-CNC are sterilized with UV light for 30 minutes, then the ingredients are dissolved in 10 ml of sterile 4.6% D-mannitol in the following order: alginate, gelatin and CMe-CNC and collagen additives or hyaluronic acid, and then, after each addition of the ingredient, the bioink is shaken in a known manner at 700 rpm for preferably 30 minutes at a temperature, preferably 37°C, and then the bioink prepared in this way is left to thoroughly mix the components for at least 12 hours, and is further cooled up to 25°C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440810A PL440810A1 (en) | 2022-03-31 | 2022-03-31 | Bioink, method of its production and application for 3D bioprinting of the meniscus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440810A PL440810A1 (en) | 2022-03-31 | 2022-03-31 | Bioink, method of its production and application for 3D bioprinting of the meniscus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL440810A1 true PL440810A1 (en) | 2023-10-02 |
Family
ID=88203782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL440810A PL440810A1 (en) | 2022-03-31 | 2022-03-31 | Bioink, method of its production and application for 3D bioprinting of the meniscus |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL440810A1 (en) |
-
2022
- 2022-03-31 PL PL440810A patent/PL440810A1/en unknown
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