PL441076A1 - Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie - Google Patents

Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

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Publication number
PL441076A1
PL441076A1 PL441076A PL44107622A PL441076A1 PL 441076 A1 PL441076 A1 PL 441076A1 PL 441076 A PL441076 A PL 441076A PL 44107622 A PL44107622 A PL 44107622A PL 441076 A1 PL441076 A1 PL 441076A1
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Poland
Prior art keywords
application
covalent complex
protein
subject matter
functional covalent
Prior art date
Application number
PL441076A
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English (en)
Inventor
Stanisław Malicki
Grzegorz Dubin
Piotr MYDEL
Joanna Kozieł
Barbara Pucelik
Edyta ŻYŁA
Małgorzata BENEDYK-MACHACZKA
Anna GOLDA
Wojciech GAŁAN
Marta KAMIŃSKA
Barbara CHRUŚCICKA-SMAGA
Alicja Sochaj-Gregorczyk
Katarzyna MAGIERA-MULARZ
Anna CZARNA
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Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL441076A priority Critical patent/PL441076A1/pl
Priority to PCT/PL2023/050030 priority patent/WO2023211299A1/en
Publication of PL441076A1 publication Critical patent/PL441076A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Pierwszym przedmiotem zgłoszenia jest aptamer wykazujący powinowactwo do białka PD-L1 posiadający sekwencję przedstawioną jako SEQ.1. Drugim przedmiotem zgłoszenia jest zastosowanie oligonukleotydu jak zdefiniowano w pierwszym przedmiocie zgłoszenia do wytwarzania funkcjonalnego kompleksu kowalencyjnego zawierającego znacznik fluoroscencyjny albo substancję powinowactwa i oligonukleotyd według pierwszego przedmiotu zgłoszenia. Kolejnym przedmiotem zgłoszenia jest funkcjonalny kompleks kowalencyjny zawierający znacznik albo substancję powinowactwa i oligonukleotyd jak zdefiniowano w pierwszym przedmiocie zgłoszenia. Zgłoszenie obejmuje również zastosowanie funkcjonalnego kompleksu kowalencyjnego w obrazowaniu diagnostycznym, zwłaszcza w obrazowaniu nowotworów.
PL441076A 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie PL441076A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie
PCT/PL2023/050030 WO2023211299A1 (en) 2022-04-30 2023-05-02 Dna aptamer having affinity for pd-l1 protein and its use, functional covalent complex and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

Publications (1)

Publication Number Publication Date
PL441076A1 true PL441076A1 (pl) 2023-11-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

Country Status (2)

Country Link
PL (1) PL441076A1 (pl)
WO (1) WO2023211299A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4574978A1 (en) * 2023-12-21 2025-06-25 Uniwersytet Jagiellonski Dna aptamer having affinity for pd-1 protein and its use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL403939A1 (pl) * 2013-05-17 2014-11-24 Uniwersytet Jagielloński Aptamery DNA rozpoznające metkę histydynową oraz ich zastosowanie
CN113156122A (zh) * 2021-04-29 2021-07-23 重庆医科大学 一种检测外泌体pd-l1的荧光传感器及其制备与应用
CN113667672A (zh) * 2021-08-09 2021-11-19 优葆优保健康科技(宁波)有限公司 一种靶向pd-l1胞外片段的dna适配体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107794268B (zh) * 2017-03-14 2021-03-26 湖南大学 检测人pdl1蛋白的核酸适体及其在制备检测制剂中的应用
CN108929874B (zh) * 2018-07-11 2021-12-14 安徽省昂普拓迈生物科技有限责任公司 一种特异性结合高表达pdl1蛋白的细胞的核酸适配体及其应用
US20230055235A1 (en) * 2019-12-27 2023-02-23 Interoligo Corporation. Anti-cancer immunotherapeutic composition for treating cancer
CN114127293B (zh) * 2020-06-30 2023-08-04 首都师范大学 一种体外筛选pd-l1的dna核酸适配体的方法及其在癌症诊断中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL403939A1 (pl) * 2013-05-17 2014-11-24 Uniwersytet Jagielloński Aptamery DNA rozpoznające metkę histydynową oraz ich zastosowanie
CN113156122A (zh) * 2021-04-29 2021-07-23 重庆医科大学 一种检测外泌体pd-l1的荧光传感器及其制备与应用
CN113667672A (zh) * 2021-08-09 2021-11-19 优葆优保健康科技(宁波)有限公司 一种靶向pd-l1胞外片段的dna适配体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI, Z.-F. ET AL.: "European Review for Medical and Pharmacological Sciences, 2021; 25: 3997-4004", "SCREENING AND CHARACTERIZATION OF APTAMERS FOR RECOMBINANT HUMAN PROGRAMMED DEATH-1 AND RECOMBINANT EXTRACELLULAR DOMAIN OF HUMAN PROGRAMMED DEATH-1 LIGAND" *

Also Published As

Publication number Publication date
WO2023211299A1 (en) 2023-11-02

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