PL441076A1 - Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie - Google Patents

Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

Info

Publication number
PL441076A1
PL441076A1 PL441076A PL44107622A PL441076A1 PL 441076 A1 PL441076 A1 PL 441076A1 PL 441076 A PL441076 A PL 441076A PL 44107622 A PL44107622 A PL 44107622A PL 441076 A1 PL441076 A1 PL 441076A1
Authority
PL
Poland
Prior art keywords
application
covalent complex
protein
subject matter
functional covalent
Prior art date
Application number
PL441076A
Other languages
English (en)
Inventor
Stanisław Malicki
Grzegorz Dubin
Piotr MYDEL
Joanna Kozieł
Barbara Pucelik
Edyta ŻYŁA
Małgorzata BENEDYK-MACHACZKA
Anna GOLDA
Wojciech GAŁAN
Marta KAMIŃSKA
Barbara CHRUŚCICKA-SMAGA
Alicja Sochaj-Gregorczyk
Katarzyna MAGIERA-MULARZ
Anna CZARNA
Original Assignee
Uniwersytet Jagielloński
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Jagielloński filed Critical Uniwersytet Jagielloński
Priority to PL441076A priority Critical patent/PL441076A1/pl
Priority to PCT/PL2023/050030 priority patent/WO2023211299A1/en
Publication of PL441076A1 publication Critical patent/PL441076A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Pierwszym przedmiotem zgłoszenia jest aptamer wykazujący powinowactwo do białka PD-L1 posiadający sekwencję przedstawioną jako SEQ.1. Drugim przedmiotem zgłoszenia jest zastosowanie oligonukleotydu jak zdefiniowano w pierwszym przedmiocie zgłoszenia do wytwarzania funkcjonalnego kompleksu kowalencyjnego zawierającego znacznik fluoroscencyjny albo substancję powinowactwa i oligonukleotyd według pierwszego przedmiotu zgłoszenia. Kolejnym przedmiotem zgłoszenia jest funkcjonalny kompleks kowalencyjny zawierający znacznik albo substancję powinowactwa i oligonukleotyd jak zdefiniowano w pierwszym przedmiocie zgłoszenia. Zgłoszenie obejmuje również zastosowanie funkcjonalnego kompleksu kowalencyjnego w obrazowaniu diagnostycznym, zwłaszcza w obrazowaniu nowotworów.
PL441076A 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie PL441076A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie
PCT/PL2023/050030 WO2023211299A1 (en) 2022-04-30 2023-05-02 Dna aptamer having affinity for pd-l1 protein and its use, functional covalent complex and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

Publications (1)

Publication Number Publication Date
PL441076A1 true PL441076A1 (pl) 2023-11-06

Family

ID=87136360

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441076A PL441076A1 (pl) 2022-04-30 2022-04-30 Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie

Country Status (2)

Country Link
PL (1) PL441076A1 (pl)
WO (1) WO2023211299A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4574978A1 (en) * 2023-12-21 2025-06-25 Uniwersytet Jagiellonski Dna aptamer having affinity for pd-1 protein and its use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL403939A1 (pl) * 2013-05-17 2014-11-24 Uniwersytet Jagielloński Aptamery DNA rozpoznające metkę histydynową oraz ich zastosowanie
CN113156122A (zh) * 2021-04-29 2021-07-23 重庆医科大学 一种检测外泌体pd-l1的荧光传感器及其制备与应用
CN113667672A (zh) * 2021-08-09 2021-11-19 优葆优保健康科技(宁波)有限公司 一种靶向pd-l1胞外片段的dna适配体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107794268B (zh) * 2017-03-14 2021-03-26 湖南大学 检测人pdl1蛋白的核酸适体及其在制备检测制剂中的应用
CN108929874B (zh) * 2018-07-11 2021-12-14 安徽省昂普拓迈生物科技有限责任公司 一种特异性结合高表达pdl1蛋白的细胞的核酸适配体及其应用
US20230055235A1 (en) * 2019-12-27 2023-02-23 Interoligo Corporation. Anti-cancer immunotherapeutic composition for treating cancer
CN114127293B (zh) * 2020-06-30 2023-08-04 首都师范大学 一种体外筛选pd-l1的dna核酸适配体的方法及其在癌症诊断中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL403939A1 (pl) * 2013-05-17 2014-11-24 Uniwersytet Jagielloński Aptamery DNA rozpoznające metkę histydynową oraz ich zastosowanie
CN113156122A (zh) * 2021-04-29 2021-07-23 重庆医科大学 一种检测外泌体pd-l1的荧光传感器及其制备与应用
CN113667672A (zh) * 2021-08-09 2021-11-19 优葆优保健康科技(宁波)有限公司 一种靶向pd-l1胞外片段的dna适配体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI, Z.-F. ET AL.: "European Review for Medical and Pharmacological Sciences, 2021; 25: 3997-4004", "SCREENING AND CHARACTERIZATION OF APTAMERS FOR RECOMBINANT HUMAN PROGRAMMED DEATH-1 AND RECOMBINANT EXTRACELLULAR DOMAIN OF HUMAN PROGRAMMED DEATH-1 LIGAND" *

Also Published As

Publication number Publication date
WO2023211299A1 (en) 2023-11-02

Similar Documents

Publication Publication Date Title
Sade-Feldman et al. Defining T cell states associated with response to checkpoint immunotherapy in melanoma
Bano et al. Evaluation of pathogenic potential of avian influenza virus serotype H9N2 in chickens
Ratushny et al. Targeting EGFR resistance networks in head and neck cancer
Kannan et al. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction
ES2182297T3 (es) Deteccion y modulacion de lo inhibidores de las proteinas de la apoptosis (iaps) y de los polipeptidos anti-apoptoticos afines (naip) para la diagnosis y tratamiento de enfermedades proliferativas.
Mendes et al. The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
Szlachcic et al. Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
Grammatico et al. Lineage switch from pro-B acute lymphoid leukemia to acute myeloid leukemia in a case with t (12; 17)(p13; q11)/TAF15–ZNF384 rearrangement
Li et al. Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells
Alvarez et al. An EdU-based flow cytometry assay to evaluate chicken T lymphocyte proliferation
Zhang et al. Isolation and characterization of ACTX-6: a cytotoxic L-amino acid oxidase from Agkistrodon acutus snake venom
Viens et al. Analysis of human histone H2AZ deposition in vivo argues against its direct role in epigenetic templating mechanisms
PL441076A1 (pl) Aptamer DNA wykazujący powinowactwo do białka PD-L1 i jego zastosowanie, funkcjonalny kompleks kowalencyjny oraz jego zastosowanie
Al‐Kzayer et al. Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards
Parte et al. Ovarian cancer stem cells: unraveling a germline connection
Parvin et al. Active virological surveillance in backyard ducks in Bangladesh: detection of avian influenza and gammacoronaviruses
Ahmed et al. Development of reliable techniques for the differential diagnosis of avian tumour viruses by immunohistochemistry and polymerase chain reaction from formalin-fixed paraffin-embedded tissue sections
Spackman et al. Analytical validation of a real-time reverse transcription polymerase chain reaction test for Pan-American lineage H7 subtype avian influenza viruses
Aureli et al. Breast cancer is associated with increased HLA-DRB1* 11: 01 and HLA-DRB1* 10: 01 allele frequency in a population of patients from central Italy
Yadav et al. Asymptomatic reactivation of SARS-CoV-2 in a child with neuroblastoma characterised by whole genome sequencing
CN103773847A (zh) 一种食品及饲料中牛源成分检测侧向流试纸条检测试剂盒及其应用
Pereira et al. Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
Vizlin-Hodzic et al. SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription
CN103773850A (zh) 一种食品及饲料中鸡源成分检测侧向流试纸条检测试剂盒及其应用
Schettino et al. The role of β1 integrin/CD29 as a potential prognostic factor for the risk of progression to cervical carcinoma in HPV-associated lesions