PL441467A1 - Sposób otrzymywania (S)-(+)-ibuprofenu - Google Patents

Sposób otrzymywania (S)-(+)-ibuprofenu

Info

Publication number
PL441467A1
PL441467A1 PL441467A PL44146722A PL441467A1 PL 441467 A1 PL441467 A1 PL 441467A1 PL 441467 A PL441467 A PL 441467A PL 44146722 A PL44146722 A PL 44146722A PL 441467 A1 PL441467 A1 PL 441467A1
Authority
PL
Poland
Prior art keywords
ibuprofen
mmol
hours
obtaining
carried out
Prior art date
Application number
PL441467A
Other languages
English (en)
Other versions
PL247882B1 (pl
Inventor
Anna Wolny
Anna Chrobok
Agnieszka Siewniak
Piotr Latos
Original Assignee
Politechnika Śląska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Śląska filed Critical Politechnika Śląska
Priority to PL441467A priority Critical patent/PL247882B1/pl
Publication of PL441467A1 publication Critical patent/PL441467A1/pl
Publication of PL247882B1 publication Critical patent/PL247882B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • C12R2001/69—Aspergillus oryzae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania (S)-(+)-ibuprofenu, który polega na tym, że reakcję estryfikacji, prowadzi się w obecności racematu ibuprofenu w ilości 1 mmol, do którego wprowadza się 0,5 mmol do 5 mmol alkoholu, następnie otrzymaną mieszaninę rozpuszcza się 0,5 ml do 5 ml w rozpuszczalnikach organicznych lub cieczach jonowych, po czym dodaje od 0,3 ml do 5 ml biokatalizatora w postaci lipazy z Aspergillus Oryzae, korzystnie 1,5 ml lipazy na 1 mmol ibuprofenu, reakcję prowadzi się w wytrząsarce w zakresie temperatur od 15°C do 40°C, w czasie 8h do 96h korzystnie 48 godzin, rozdziela przez destylację i poddaje hydrolizie.
PL441467A 2022-06-13 2022-06-13 Sposób otrzymywania (S)-(+)-ibuprofenu PL247882B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL441467A PL247882B1 (pl) 2022-06-13 2022-06-13 Sposób otrzymywania (S)-(+)-ibuprofenu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441467A PL247882B1 (pl) 2022-06-13 2022-06-13 Sposób otrzymywania (S)-(+)-ibuprofenu

Publications (2)

Publication Number Publication Date
PL441467A1 true PL441467A1 (pl) 2023-12-18
PL247882B1 PL247882B1 (pl) 2025-09-15

Family

ID=89452823

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441467A PL247882B1 (pl) 2022-06-13 2022-06-13 Sposób otrzymywania (S)-(+)-ibuprofenu

Country Status (1)

Country Link
PL (1) PL247882B1 (pl)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101104861A (zh) * 2007-04-28 2008-01-16 北京化工大学 生物催化制备s-布洛芬及s-布洛芬酯的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101104861A (zh) * 2007-04-28 2008-01-16 北京化工大学 生物催化制备s-布洛芬及s-布洛芬酯的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CARVALHO, PATRICIA DE OLIVEIRA, FABIANO JARES CONTESINI, RENATO BIZACO, SILVANA A. CALAFATTI AND GABRIELA ALVES MACÊDO, OPTIMIZATION OF ENANTIOSELECTIVE RESOLUTION OF RACEMIC IBUPROFEN BY NATIVE LIPASE FROM ASPERGILLUS NIGER, JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY 33 (2006): 713-718, DOI:10.1007/S10295-006-0138-8 *
CONTESINI, FABIANO JARES AND PATRICIA DE OLIVEIRA CARVALHO, ESTERIFICATION OF (RS)-IBUPROFEN BY NATIVE AND COMMERCIAL LIPASES IN A TWO-PHASE SYSTEM CONTAINING IONIC LIQUIDS, TETRAHEDRON-ASYMMETRY 17 (2006): 2069-2073; DOI:10.1016/J.TETASY.2006.07.020 *

Also Published As

Publication number Publication date
PL247882B1 (pl) 2025-09-15

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