PL442880A1 - Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue - Google Patents

Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue

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Publication number
PL442880A1
PL442880A1 PL442880A PL44288022A PL442880A1 PL 442880 A1 PL442880 A1 PL 442880A1 PL 442880 A PL442880 A PL 442880A PL 44288022 A PL44288022 A PL 44288022A PL 442880 A1 PL442880 A1 PL 442880A1
Authority
PL
Poland
Prior art keywords
antimicrobial
inflammatory effects
bone tissue
regenerating
filling
Prior art date
Application number
PL442880A
Other languages
Polish (pl)
Inventor
Monika Biernat
Lidia Ciołek
Anna Woźniak
Zbigniew Jaegermann
Agnieszka Kubiś
Natalia Karska
Justyna Sawicka
Sylwia RODZIEWICZ-MOTOWIDŁO
Milena Chraniuk
Beata Gromadzka
Mirosława Panasiuk
Piotr Bollin
Original Assignee
Sieć Badawcza Łukasiewicz - Instytut Ceramiki I Materiałów Budowlanych
Uniwersytet Gdański
Politechnika Wrocławska
Instytut Biotechnologii I Medycyny Molekularnej
Sensdx Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sieć Badawcza Łukasiewicz - Instytut Ceramiki I Materiałów Budowlanych, Uniwersytet Gdański, Politechnika Wrocławska, Instytut Biotechnologii I Medycyny Molekularnej, Sensdx Spółka Akcyjna filed Critical Sieć Badawcza Łukasiewicz - Instytut Ceramiki I Materiałów Budowlanych
Priority to PL442880A priority Critical patent/PL442880A1/en
Publication of PL442880A1 publication Critical patent/PL442880A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Composite Materials (AREA)
  • Ceramic Engineering (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia są porowate kompozyty przeznaczone do stosowania jako biozgodny materiał do wypełnień ubytków kostnych i regeneracji tkanki kostnej, w których matrycę polimerową stanowi chitozan, wypełniacz stanowi bioszkło, a całość jest wzbogacona aktywnym biologicznie, opracowanym peptydem o specyficznej sekwencji aminokwasów, o udowodnionych właściwościach przeciwdrobnoustrojowych i przeciwzapalnych — w opisie patentowym nazywany jako „ug46” lub jest wzbogacona tym peptydem w postaci fibryli o udowodnionych właściwościach przeciwdrobnoustrojowych — w opisie patentowym nazywanymi jako „UG46”. Przedmiotem zgłoszenia jest również sposób otrzymywania kompozytów. Opracowano dwa warianty: kompozyt: chitozan z bioszkłem i opracowanym peptydem oznaczanym jako „ug46”, kompozyt: chitozan z bioszkłem i fibrylami peptydowymi oznaczanymi jako „UG46” otrzymanymi z peptydu „ug46”. Rozwiązanie znajduje zastosowanie jako materiał porowaty do stosowania jako biozgodny materiał do wypełnień ubytków kostnych i/lub regeneracji tkanki kostnej.The subject of the application are porous composites intended for use as a biocompatible material for filling bone defects and regenerating bone tissue, in which the polymer matrix is chitosan, the filler is bioglass, and the whole is enriched with a biologically active, developed peptide with a specific sequence of amino acids, with proven antimicrobial and antimicrobial properties. anti-inflammatory - in the patent description called "UG46" or is enriched with this peptide in the form of fibrils with proven antimicrobial properties - in the patent description called "UG46". The subject of the application is also the method of obtaining composites. Two variants were developed: composite: chitosan with bioglass and the developed peptide designated as "ug46", composite: chitosan with bioglass and peptide fibrils designated as "UG46" obtained from the "ug46" peptide. The solution is used as a porous material for use as a biocompatible material for filling bone defects and/or regenerating bone tissue.

PL442880A 2022-11-18 2022-11-18 Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue PL442880A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL442880A PL442880A1 (en) 2022-11-18 2022-11-18 Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL442880A PL442880A1 (en) 2022-11-18 2022-11-18 Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue

Publications (1)

Publication Number Publication Date
PL442880A1 true PL442880A1 (en) 2024-05-20

Family

ID=91128920

Family Applications (1)

Application Number Title Priority Date Filing Date
PL442880A PL442880A1 (en) 2022-11-18 2022-11-18 Multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue and method of obtaining multifunctional composites with antimicrobial and anti-inflammatory effects for filling bone defects and regenerating bone tissue

Country Status (1)

Country Link
PL (1) PL442880A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102294049A (en) * 2011-09-05 2011-12-28 祝少博 Bioactive glass and chitosan composite bone repair material and preparation method and application thereof
CN114873921A (en) * 2022-03-16 2022-08-09 苏州延生堂医疗器械科技有限公司 A kind of porous biological glass ceramics degradable bone wound material containing organic polymer and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102294049A (en) * 2011-09-05 2011-12-28 祝少博 Bioactive glass and chitosan composite bone repair material and preparation method and application thereof
CN114873921A (en) * 2022-03-16 2022-08-09 苏州延生堂医疗器械科技有限公司 A kind of porous biological glass ceramics degradable bone wound material containing organic polymer and preparation method thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ELKE M. F. LEMOS ET AL., "3D NANOCOMPOSITE CHITOSAN/BIOACTIVE GLASS SCAFFOLDS OBTAINED USING TWO DIFFERENT ROUTES: AN EVALUATION OF THE POROUS STRUCTURE AND MECHANICAL PROPERTIES" MAY 2016, QUÍMICA NOVA 39(4) *
K. KONNO ET AL., "ANOPLIN, A NOVEL ANTIMICROBIAL PEPTIDE FROM THE VENOM OF THE SOLITARY WASP ANOPLIUS SAMARIENSIS", BIOCHIM BIOPHYS ACTA. 2001 NOV 26;1550(1):70-80, ABSTRACT *
MILENA CHRANIUK ET AL., "ASSESSMENT OF THE TOXICITY OF BIOCOMPATIBLE MATERIALS SUPPORTING BONE REGENERATION: IMPACT OF THE TYPE OF ASSAY AND USED CONTROLS", TOXICS 2022, 10(1), 20, PUBLISHED: 6 JANUARY 2022 *
MONIKA BIERNAT ET AL., "POROUS CHITOSAN/ZNO-DOPED BIOGLASS COMPOSITES AS CARRIERS OF BIOACTIVE PEPTIDES", INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY , AUGUST 2020 VOLUME17, ISSUE6, ABSTRACT *
ZHEJUN WANG ET AL., "ANTIMICROBIAL AND ANTIBIOFILM PROPERTIES OF BIOCERAMIC MATERIALS IN ENDODONTICS", MATERIALS (BASEL). 2021 DEC; 14(24): 759 *
ZIMOCH-KORZYCKA ET AL., „CHITOSAN AND CYSTATIN/LYSOZYME PREPARATION AS PROTECTIVE EDIBLE FILMS COMPONENTS.", INTERNATIONAL JOURNAL OF POLYMER SCIENCE, 2015. 1-10 *

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