PL443403A1 - Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych - Google Patents

Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych

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Publication number
PL443403A1
PL443403A1 PL443403A PL44340323A PL443403A1 PL 443403 A1 PL443403 A1 PL 443403A1 PL 443403 A PL443403 A PL 443403A PL 44340323 A PL44340323 A PL 44340323A PL 443403 A1 PL443403 A1 PL 443403A1
Authority
PL
Poland
Prior art keywords
chitosan
bioink
composite
composite based
hydrogel
Prior art date
Application number
PL443403A
Other languages
English (en)
Inventor
Szymon Mania
Robert TYLINGO
Adrianna Banach-Kopeć
Michał PIKUŁA
Milena Deptuła
Agata Wawrzynowicz
Katarzyna Czerwiec
Original Assignee
Politechnika Gdańska
Gdański Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Politechnika Gdańska, Gdański Uniwersytet Medyczny filed Critical Politechnika Gdańska
Priority to PL443403A priority Critical patent/PL443403A1/pl
Priority to EP23460040.1A priority patent/EP4397330A1/en
Publication of PL443403A1 publication Critical patent/PL443403A1/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/72—Chitin, chitosan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest termoczuły kompozyt na bazie hydrożelu chitozanu i agarozy, mogący mieć formę zolu lub żelu oraz sposób wytwarzania kompozytu mogącego przybrać postać biotuszu opartego na hydrożelu chitozanu i agarozy, którego dobrany skład determinuje szybkość i temperaturę przemiany fazowej zol-żel. Dzięki możliwości termoregulacji wspomnianej przemiany kompozyt hydrożeli chitozanu i agarozy można wykorzystać w formie biotuszu do tworzenia przestrzennych obiektów z wykorzystaniem technologii wytwarzania addytywnego, stąd też przedmiotem zgłoszenia jest zastosowanie biotuszu. Zgłoszenie dotyczy również takiego zastosowania kompozytu. Obiekty 3D wytworzone na bazie biotuszu mogą pełnić rolę uniwersalnego rusztowania spełniającego wymagania niezbędne do przeżywania, namnażania się i różnicowania umieszonych w nim komórek. Wynalazek ten ma zastosowanie zwłaszcza jako matryca do hodowli komórkowej w otrzymywaniu produktów żywnościowych, medycznych i kosmetycznych.
PL443403A 2023-01-03 2023-01-03 Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych PL443403A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL443403A PL443403A1 (pl) 2023-01-03 2023-01-03 Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych
EP23460040.1A EP4397330A1 (en) 2023-01-03 2023-12-05 Hydrogel based on chitosan and agarose for use as bio-ink.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443403A PL443403A1 (pl) 2023-01-03 2023-01-03 Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych

Publications (1)

Publication Number Publication Date
PL443403A1 true PL443403A1 (pl) 2024-07-08

Family

ID=89620130

Family Applications (1)

Application Number Title Priority Date Filing Date
PL443403A PL443403A1 (pl) 2023-01-03 2023-01-03 Hydrożelowy kompozyt na bazie chitozanu, sposób wytwarzania hydrożelowego kompozytu na bazie chitozanu oraz zastosowanie kompozytu w postaci biotuszu do tworzenia przestrzennych obiektów, zwłaszcza z wykorzystaniem technologii wytwarzania addytywnego, zwłaszcza celem prowadzenia hodowli komórkowych

Country Status (2)

Country Link
EP (1) EP4397330A1 (pl)
PL (1) PL443403A1 (pl)

Citations (2)

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KR102124579B1 (ko) * 2018-12-04 2020-06-18 한국생산기술연구원 세포 괴사를 최소화하는 바이오잉크 조성물 및 이를 이용한 생체구조체의 제조방법
WO2022153319A1 (en) * 2021-01-18 2022-07-21 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) A sodium alginate, gelatin, collagen and fibrin (agcf) based bio-ink for the bioprinting of a 3d biogel-based tissue/structure

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DE10117234A1 (de) 2001-04-06 2002-10-10 Alvito Biotechnologie Gmbh Poröse und nichtporöse Matrices auf Basis von Chitosan und Hydroxycarbonsäuren
ES2353116T3 (es) 2002-07-16 2011-02-25 Bio Syntech Canada Inc. Composiciones para disoluciones de quitosano citocompatibles, inyectables, autogelificantes para encapsular y administrar células vivas o factores biológicamente activos.
CN101148520B (zh) 2007-10-19 2011-08-24 浙江大学 一种温度敏感的壳聚糖水凝胶
EP2920240B1 (en) * 2012-07-20 2022-03-09 Politechnika Gdanska The method of obtaining the aqueous solution of chitosan, chitosan composition, chitosan aerosol, the method of producing the chitosan hydrogel membrane and the method of producing chitosan-protein biopolymer material
FR3029116B1 (fr) 2014-12-01 2018-03-30 Advanced Chitosan Solutions Biotech Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
KR101757977B1 (ko) 2015-06-26 2017-07-13 아주대학교산학협력단 바이오 잉크의 제조방법 및 3d 프린터 적용
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WO2022153319A1 (en) * 2021-01-18 2022-07-21 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) A sodium alginate, gelatin, collagen and fibrin (agcf) based bio-ink for the bioprinting of a 3d biogel-based tissue/structure

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