PL446668A1 - Sposób otrzymywania 9-tio-1,N2-etenoguanozyny/ 9-tio-1,N2-etenoguaniny - Google Patents
Sposób otrzymywania 9-tio-1,N2-etenoguanozyny/ 9-tio-1,N2-etenoguaninyInfo
- Publication number
- PL446668A1 PL446668A1 PL446668A PL44666823A PL446668A1 PL 446668 A1 PL446668 A1 PL 446668A1 PL 446668 A PL446668 A PL 446668A PL 44666823 A PL44666823 A PL 44666823A PL 446668 A1 PL446668 A1 PL 446668A1
- Authority
- PL
- Poland
- Prior art keywords
- thio
- ethenoguanine
- ethenoguanosine
- obtaining
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania 9-tio-1,N2-etenoguanozyny / 9-tio-1,N2-etenoguaniny. Sposób otrzymywania 9-tio-1,N2-etenoguanozyny / 9-tio-1,N2-etenoguaniny o wzorze ogólnym 1,w którym R — oznacza H, rybozę, grupę metylową, polega na tym, że reakcję 6-tioguanozyny / 6-tioguaniny z aldehydem octowym, prowadzi-się w jednym reaktorze, w środowisku wodnym albo buforze PBS przy kontroli pH reakcji tak, żeby utrzymać wartości pomiędzy pH 6,0 - 7,0; gdzie aldehyd chlorooctowy o wzorze 3 dodaje się w ilości od 20 do 200 części aldehydu w stosunku do 1 części związku o wzorze 2, w którym R — oznacza: ,H, rybozę, grupę metylową, korzystnie w stosunku 1:50, przy czym reakcję prowadzi się w zakresie stężeń 6-tioguaniny/ 6-tioguanozyny od 1,5 x 10-4 M do 1,0 x 10-3 M w temperaturze od 25°C do 37°C, korzystnie w 37°C, korzystnie bez dostępu światła o długości poniżej 390 nm, do otrzymania 9-tio-1,N2-etenoguaniny/9-tio-1,N2-etenoguanozyny, dalej roztwór odparowuje się, a powstałą sól usuwa się przez wymywanie i oczyszczanie na kolumnie chromatograficznej.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL446668A PL249874B1 (pl) | 2023-11-07 | 2023-11-07 | Sposób otrzymywania 9-tio-1,N2-etenoguanozyny/ 9-tio-1,N2-etenoguaniny |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL446668A PL249874B1 (pl) | 2023-11-07 | 2023-11-07 | Sposób otrzymywania 9-tio-1,N2-etenoguanozyny/ 9-tio-1,N2-etenoguaniny |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL446668A1 true PL446668A1 (pl) | 2025-05-12 |
| PL249874B1 PL249874B1 (pl) | 2026-07-06 |
Family
ID=95653674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL446668A PL249874B1 (pl) | 2023-11-07 | 2023-11-07 | Sposób otrzymywania 9-tio-1,N2-etenoguanozyny/ 9-tio-1,N2-etenoguaniny |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL249874B1 (pl) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1690058A (zh) * | 2004-04-19 | 2005-11-02 | 蔡文革 | 一种制备硫鸟嘌呤的方法 |
| CN111440170A (zh) * | 2020-04-22 | 2020-07-24 | 通辽德胜生物科技有限公司 | 一种利用鸟苷合成鸟嘌呤的方法 |
| CN112522351A (zh) * | 2020-12-28 | 2021-03-19 | 广东肇庆星湖生物科技股份有限公司 | 一种鸟嘌呤的合成方法 |
-
2023
- 2023-11-07 PL PL446668A patent/PL249874B1/pl unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1690058A (zh) * | 2004-04-19 | 2005-11-02 | 蔡文革 | 一种制备硫鸟嘌呤的方法 |
| CN111440170A (zh) * | 2020-04-22 | 2020-07-24 | 通辽德胜生物科技有限公司 | 一种利用鸟苷合成鸟嘌呤的方法 |
| CN112522351A (zh) * | 2020-12-28 | 2021-03-19 | 广东肇庆星湖生物科技股份有限公司 | 一种鸟嘌呤的合成方法 |
Non-Patent Citations (1)
| Title |
|---|
| KATARZYNA KRANCEWICZ ET AL: "Int. J. Mol. Sci. 2023, 24(10), 8990; https://doi.org/10.3390/ijms24108990", THIOPURINES ANALOGUES WITH ADDITIONAL RING: SYNTHESIS, SPECTROSCOPIC PROPERTIES, AND ANTICANCER POTENCY * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL249874B1 (pl) | 2026-07-06 |
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