PL447175A1 - Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu - Google Patents

Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu

Info

Publication number
PL447175A1
PL447175A1 PL447175A PL44717523A PL447175A1 PL 447175 A1 PL447175 A1 PL 447175A1 PL 447175 A PL447175 A PL 447175A PL 44717523 A PL44717523 A PL 44717523A PL 447175 A1 PL447175 A1 PL 447175A1
Authority
PL
Poland
Prior art keywords
liposomes
active substances
pharmacologically active
treatment
local delivery
Prior art date
Application number
PL447175A
Other languages
English (en)
Inventor
Magdalena PRZYBYŁO
Tomasz Borowik
Marek Langner
Paweł GRIEB
Original Assignee
Lipotech Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotech Spółka Z Ograniczoną Odpowiedzialnością filed Critical Lipotech Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL447175A priority Critical patent/PL447175A1/pl
Publication of PL447175A1 publication Critical patent/PL447175A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)

Abstract

Przedmiotem wynalazku jest zawiesina liposomów do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu, charakteryzująca się tym, że liposomy zbudowane są z jednej dwuwarstwy lipidowej zamykającej przestrzeń hydrofilową, przy czym w ich skład wchodzą: co najmniej jeden neutralny związek amfifilowy, co najmniej jeden amfifilowy związek kationowy tworzące dwuwarstwę lipidową, przynajmniej jedna hydrofobowa bądź hydrofilowa substancja farmakologicznie czynna, glikol propylenowy lub gliceryna oraz roztwór wodny. Średnica liposomów mieści się zakresie od 50 nm do 300 nm, a zawartość substancji kationowej nie przekracza 5 mol%. Wynalazek dotyczy również sposobu tworzenia liposomowych nośników z przeznaczeniem do zastosowań okulistycznych i charakteryzujących się wysoką wydajnością zamykania substancji czynnych
PL447175A 2023-12-19 2023-12-19 Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu PL447175A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447175A PL447175A1 (pl) 2023-12-19 2023-12-19 Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447175A PL447175A1 (pl) 2023-12-19 2023-12-19 Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu

Publications (1)

Publication Number Publication Date
PL447175A1 true PL447175A1 (pl) 2025-06-23

Family

ID=96092924

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447175A PL447175A1 (pl) 2023-12-19 2023-12-19 Liposomy do miejscowego dostarczania substancji farmakologicznie czynnych w leczeniu chorób oczu

Country Status (1)

Country Link
PL (1) PL447175A1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1415291A1 (en) * 2001-06-20 2004-05-06 Leapfrog Enterprises, Inc. Interactive apparatus using print media
PL402511A1 (pl) * 2013-01-21 2014-08-04 Lipid Systems Spółka Z Ograniczoną Odpowiedzialnością Formulacja liposomowa nizyny
WO2018172504A1 (en) * 2017-03-23 2018-09-27 Lipid Systems Sp. Z.O.O. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1415291A1 (en) * 2001-06-20 2004-05-06 Leapfrog Enterprises, Inc. Interactive apparatus using print media
PL402511A1 (pl) * 2013-01-21 2014-08-04 Lipid Systems Spółka Z Ograniczoną Odpowiedzialnością Formulacja liposomowa nizyny
WO2018172504A1 (en) * 2017-03-23 2018-09-27 Lipid Systems Sp. Z.O.O. High-efficiency encapsulation of hydrophilic compounds in unilamellar liposomes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LONEZ C, VANDENBRANDEN M, RUYSSCHAERT JM: "Prog Lipid Res. 2008 Sep;47(5):340-7.", CATIONIC LIPOSOMAL LIPIDS: FROM GENE CARRIERS TO CELL SIGNALING, DOI: 10.1016/j.plipres.2008.03.002 *

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