PL447879A1 - Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki - Google Patents

Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki

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Publication number
PL447879A1
PL447879A1 PL447879A PL44787924A PL447879A1 PL 447879 A1 PL447879 A1 PL 447879A1 PL 447879 A PL447879 A PL 447879A PL 44787924 A PL44787924 A PL 44787924A PL 447879 A1 PL447879 A1 PL 447879A1
Authority
PL
Poland
Prior art keywords
epilepsy
epileptogenesis
monitoring
microrna
subject
Prior art date
Application number
PL447879A
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English (en)
Inventor
Katarzyna Łukasiuk
Kinga Szydłowska
Piotr Chrościcki
Katarzyna Piwocka
Original Assignee
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk
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Application filed by Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk filed Critical Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk
Priority to PL447879A priority Critical patent/PL447879A1/pl
Publication of PL447879A1 publication Critical patent/PL447879A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Niniejszy wynalazekdostarcza sposobu diagnozowania i monitorowania er vivo epileptogenezy i padaczki, charakteryzujący się tym, że sposób obejmuje następujące etapy: a) oznaczania in vitro sygnatury co najmniej rno-miR-155-5p (SEKW. NR ID.: 1) i rno-miR-674-3p (SEKW. NR ID.: 1) jako biomarkera mikroRNA w próbce pełnej krwi osobnika oraz b) porównywania oznaczonej sygnatury każdego mikroRNA z jego średnią sygnaturą obserwowaną w próbce kontrolnej. Niniejszy wynalazek ponadto dostarcza sposobu monitorowania progresji lub nasilenia epileptogenezy i padaczki u osobnika lub monitorowania odpowiedzi osobnika na leczenie epileptogenezy i padaczki oraz sposobu leczenia epileptogenezy i padaczki u osobnika. Ponadto, niniejszy wynalazek zapewnia panel biomarkerów mikroRNA i zastosowanie panelu biomarkerów mikroRNA.
PL447879A 2024-02-28 2024-02-28 Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki PL447879A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447879A PL447879A1 (pl) 2024-02-28 2024-02-28 Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447879A PL447879A1 (pl) 2024-02-28 2024-02-28 Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki

Publications (1)

Publication Number Publication Date
PL447879A1 true PL447879A1 (pl) 2025-09-01

Family

ID=96877525

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447879A PL447879A1 (pl) 2024-02-28 2024-02-28 Struktury microRNA do predykcji, monitorowania i diagnozowania epileptogenezy i padaczki

Country Status (1)

Country Link
PL (1) PL447879A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190249250A1 (en) * 2015-11-20 2019-08-15 Braindtech S.R.L. Microglia Microvesicles Contained MicroRNA-Based Methods For The Diagnosis, Prognosis And Treatment Monitoring Of Neurological, Neurodegenerative And Inflammation-Based Diseases
US20220307076A1 (en) * 2016-06-06 2022-09-29 Redvault Biosciences, Lp Target reporter constructs and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190249250A1 (en) * 2015-11-20 2019-08-15 Braindtech S.R.L. Microglia Microvesicles Contained MicroRNA-Based Methods For The Diagnosis, Prognosis And Treatment Monitoring Of Neurological, Neurodegenerative And Inflammation-Based Diseases
US20220307076A1 (en) * 2016-06-06 2022-09-29 Redvault Biosciences, Lp Target reporter constructs and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUAN W, CHEN Y AND WANG XR: "Int J Mol Med 42: 1577-1584, 2018", MICRORNA‑155 CONTRIBUTES TO THE OCCURRENCE OF EPILEPSY THROUGH THE PI3K/AKT/MTOR SIGNALING PATHWAY *
RONCON P, SOUKUPOVÀ M, BINASCHI A, FALCICCHIA C, ZUCCHINI S, FERRACIN M, LANGLEY SR, PETRETTO E, JOHNSON MR, MARUCCI G, MICHELUCCI: "Sci Rep. 2015 Sep 18;5:14143", MICRORNA PROFILES IN HIPPOCAMPAL GRANULE CELLS AND PLASMA OF RATS WITH PILOCARPINE-INDUCED EPILEPSY-COMPARISON WITH HUMAN EPILEPTIC SAMPLES *

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