PL447910A1 - Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu - Google Patents

Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu

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Publication number
PL447910A1
PL447910A1 PL447910A PL44791024A PL447910A1 PL 447910 A1 PL447910 A1 PL 447910A1 PL 447910 A PL447910 A PL 447910A PL 44791024 A PL44791024 A PL 44791024A PL 447910 A1 PL447910 A1 PL 447910A1
Authority
PL
Poland
Prior art keywords
meta
derivatives
methylimidazo
aryl
para
Prior art date
Application number
PL447910A
Other languages
English (en)
Inventor
Agata Paneth
Katarzyna Dzitko
Adrian Bekier
Anita Ciesielska
Original Assignee
Uniwersytet Medyczny W Lublinie
Uniwersytet Łódzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny W Lublinie, Uniwersytet Łódzki filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL447910A priority Critical patent/PL447910A1/pl
Publication of PL447910A1 publication Critical patent/PL447910A1/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Zgłoszenie rozwiązuje problem aktywności i nowego zastosowania pochodnych imidazolotiosemikarbazydu do zwalczania infekcji wywołanych przez dermatofity, gdzie aktywność ta jest korzystniejsza od stosowanych leków azolowych. Istota wynalazku dotyczy nowego zastosowania pochodnych imidazolotiosemikarbazydu o wzorze 1 przedstawionym na rysunku, gdzie R1 oznacza podstawnik meta-jodowy, meta-bromowy, orto-nitrowy, meta-nitrowy, para-nitrowy, orto-metylowy, meta-metylowy, para-metylowy, para-acetylowy do zwalczania infekcji wywołanych przez dermatofity porównywalną do stosowanych leków azolowych. Korzystnie pochodne te stosuje się do wytwarzania leku przeznaczonego do zwalczania infekcji dermatofitowych.
PL447910A 2024-03-01 2024-03-01 Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu PL447910A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447910A PL447910A1 (pl) 2024-03-01 2024-03-01 Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447910A PL447910A1 (pl) 2024-03-01 2024-03-01 Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu

Publications (1)

Publication Number Publication Date
PL447910A1 true PL447910A1 (pl) 2025-09-08

Family

ID=96946638

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447910A PL447910A1 (pl) 2024-03-01 2024-03-01 Nowe zastosowanie medyczne pochodnych 4-arylo-1-(4-metyloimidazo-5-ilo) tiosemikarbazydu

Country Status (1)

Country Link
PL (1) PL447910A1 (pl)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL426156A1 (pl) * 2018-06-29 2020-01-02 Uniwersytet Medyczny W Lublinie Pochodne 4-jodofenylo-1-(4-metyloimidazol-5-ilo)tiosemikarbazydu, sposób ich wytwarzania i zastosowanie medyczne

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL426156A1 (pl) * 2018-06-29 2020-01-02 Uniwersytet Medyczny W Lublinie Pochodne 4-jodofenylo-1-(4-metyloimidazol-5-ilo)tiosemikarbazydu, sposób ich wytwarzania i zastosowanie medyczne

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEKIER, A ET AL.: "Cells. 2021 Dec 9; 10(12): 3476", IMIDAZOLE-THIOSEMICARBAZIDE DERIVATIVES AS POTENT ANTI-MYCOBACTERIUM TUBERCULOSIS COMPOUNDS WITH ANTIBIOFILM ACTIVITY. *
DALLA LANA, DF ET AL.: "J Appl Microbiol. 2015; 119(2): 377-88", IMIDAZOLIUM SALTS WITH ANTIFUNGAL POTENTIAL AGAINST MULTIDRUG-RESISTANT DERMATOPHYTES. *
PANETH, A ET AL.: "Molecules. 2019 Apr 24;24(8):1618", DISCOVERY OF POTENT AND SELECTIVE HALOGEN-SUBSTITUTED IMIDAZOLE-THIOSEMICARBAZIDES FOR INHIBITION OF TOXOPLASMA GONDII GROWTH IN VITRO VIA STRUCTURE-BASED DESIGN. *
PANETH, A. ET AL.: "Molecules. 2019; 24(3): 614", SYSTEMATIC IDENTIFICATION OF THIOSEMICARBAZIDES FOR INHIBITION OF TOXOPLASMA GONDII GROWTH IN VITRO. *

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