PL448609A1 - Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone - Google Patents

Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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Publication number
PL448609A1
PL448609A1 PL448609A PL44860924A PL448609A1 PL 448609 A1 PL448609 A1 PL 448609A1 PL 448609 A PL448609 A PL 448609A PL 44860924 A PL44860924 A PL 44860924A PL 448609 A1 PL448609 A1 PL 448609A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
flavone
chloro
producing
hours
Prior art date
Application number
PL448609A
Other languages
Polish (pl)
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL448609A priority Critical patent/PL448609A1/en
Publication of PL448609A1 publication Critical patent/PL448609A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 3'-chloro-4'-O-â-D-(4"-O-metyloglukopiranozylo)-flawonu charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Beauveria bassiana KCH J1.5, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 3'-chloroflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 3'-chloro-4'-O-â-D(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is a method for producing 3'-chloro-4'-O-α-D-(4"-O-methylglucopyranosyl)-flavone, characterized in that the Beauveria bassiana KCH J1.5 strain is introduced into a medium suitable for filamentous fungi, then after at least 72 hours, a substrate, which is 3'-chloroflavone of formula 1, dissolved in an organic solvent miscible with water, is introduced into the culture, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with an organic solvent immiscible with water and purified chromatographically, wherein 3'-chloro-4'-O-α-D(4"-O-methylglucopyranosyl)-flavone of formula 2 is located in the fraction of intermediate polarity, in the second band from the starting line.

PL448609A 2024-05-20 2024-05-20 Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone PL448609A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL448609A PL448609A1 (en) 2024-05-20 2024-05-20 Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL448609A PL448609A1 (en) 2024-05-20 2024-05-20 Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Publications (1)

Publication Number Publication Date
PL448609A1 true PL448609A1 (en) 2025-11-24

Family

ID=97752650

Family Applications (1)

Application Number Title Priority Date Filing Date
PL448609A PL448609A1 (en) 2024-05-20 2024-05-20 Method for producing 3'-chloro-4'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Country Status (1)

Country Link
PL (1) PL448609A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238972B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6,8-Dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6,8-dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone
PL240095B1 (en) * 2019-01-31 2022-02-14 Wrocław University Of Environmental And Life Sciences 4'-O-β-D-(4"-O-Methylglucopyranosyl)-2',5'-dimethoxyflavone and method of preparing 4'-O-β-D-(4"-O-methylglucopyranosyl)-2',5'-dimethoxyflavone
PL242468B1 (en) * 2021-01-15 2023-02-27 Wrocław University Of Environmental And Life Sciences Method for producing 6-Methyl-4'-O-β-D- (4 '- O-methylglucopyranosyl) -flavanone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL240095B1 (en) * 2019-01-31 2022-02-14 Wrocław University Of Environmental And Life Sciences 4'-O-β-D-(4"-O-Methylglucopyranosyl)-2',5'-dimethoxyflavone and method of preparing 4'-O-β-D-(4"-O-methylglucopyranosyl)-2',5'-dimethoxyflavone
PL238972B1 (en) * 2019-09-16 2021-10-25 Wrocław University Of Environmental And Life Sciences 6,8-Dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone and method of producing 6,8-dichloro-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavone
PL242468B1 (en) * 2021-01-15 2023-02-27 Wrocław University Of Environmental And Life Sciences Method for producing 6-Methyl-4'-O-β-D- (4 '- O-methylglucopyranosyl) -flavanone

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