PL449074A1 - Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them - Google Patents

Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them

Info

Publication number
PL449074A1
PL449074A1 PL449074A PL44907424A PL449074A1 PL 449074 A1 PL449074 A1 PL 449074A1 PL 449074 A PL449074 A PL 449074A PL 44907424 A PL44907424 A PL 44907424A PL 449074 A1 PL449074 A1 PL 449074A1
Authority
PL
Poland
Prior art keywords
agent
antimicrobial
microorganisms
antimicrobial properties
peptide
Prior art date
Application number
PL449074A
Other languages
Polish (pl)
Inventor
Magdalena KAUS-DROBEK
Izabela SABAŁA
Marzena NOWACKA
Małgorzata KORZENIOWSKA
Paweł MITKOWSKI
Alicja RAZEW
Elżbieta JAGIELSKA
Original Assignee
Instytut Medycyny Doświadczalnej I Klinicznej Im. M. Mossakowskiego Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Medycyny Doświadczalnej I Klinicznej Im. M. Mossakowskiego Polskiej Akademii Nauk filed Critical Instytut Medycyny Doświadczalnej I Klinicznej Im. M. Mossakowskiego Polskiej Akademii Nauk
Priority to PCT/PL2024/050045 priority Critical patent/WO2026005624A1/en
Priority to PL449074A priority patent/PL449074A1/en
Publication of PL449074A1 publication Critical patent/PL449074A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24075—Lysostaphin (3.4.24.75)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Zgłoszenie dotyczy rekombinowanego białka o właściwościach przeciwdrobnoustrojowych o sekwencji aminokwasowej o co najmniej 80% identyczności z sekwencją domeny wiążącej ściany komórkowe CBD_Sp_B z Staphylococcus pettenkoferi jak przedstawioną w SEQ ID No.1., peptydu o właściwościach przeciwdrobnoustrojowych, kompozycji je zawierających, sposobów je wykorzystujących i ich zastosowania jako środka antybakteryjnego i/lub środka przeciwgrzybiczego, środka antyseptycznego i dezynfekującego, środka przeciwdrobnoustrojowego do odkażania powierzchni i pomieszczeń w przetwórstwie żywności, środka przeciwdrobnoustrojowego w przemyśle spożywczym, środka odkażającego, środka zapobiegającego i ograniczającego rozwój drobnoustrojów na powierzchniach, środka ochrony roślin, środka konserwującego materiały, jako środka zapobiegającego biodeterioracji przez drobnoustroje, in vitro środka przeciwdrobnoustrojowego o działaniu antybakteryjnym w przemyśle kosmetycznym, kompozycji weterynaryjnej i farmaceutycznej do zastosowania jako lek w profilaktyce, zapobieganiu i leczeniu choroby i/lub stanu spowodowanego przez drobnoustroje wybrane z bakterii i/lub grzybów.The application relates to a recombinant protein with antimicrobial properties having an amino acid sequence with at least 80% identity to the sequence of the cell wall binding domain CBD_Sp_B from Staphylococcus pettenkoferi as shown in SEQ ID No. 1., a peptide with antimicrobial properties, compositions containing them, methods of using them and their use as an antibacterial agent and/or antifungal agent, an antiseptic and disinfectant agent, an antimicrobial agent for disinfecting surfaces and rooms in food processing, an antimicrobial agent in the food industry, a disinfectant agent, an agent preventing and limiting the growth of microorganisms on surfaces, a plant protection agent, a material preservative, as an agent preventing biodeterioration by microorganisms, an in vitro antimicrobial agent with antibacterial action in the cosmetics industry, a veterinary and pharmaceutical composition for use as a medicine in the prophylaxis, prevention and treatment of a disease and/or condition caused by microorganisms selected from the group consisting of: from bacteria and/or fungi.

PL449074A 2024-06-29 2024-06-29 Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them PL449074A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/PL2024/050045 WO2026005624A1 (en) 2024-06-29 2024-06-29 Recombinant protein and peptide with antimicrobial properties, compositions comprising them, uses and methods utilizing thereof
PL449074A PL449074A1 (en) 2024-06-29 2024-06-29 Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL449074A PL449074A1 (en) 2024-06-29 2024-06-29 Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them

Publications (1)

Publication Number Publication Date
PL449074A1 true PL449074A1 (en) 2026-01-05

Family

ID=98222607

Family Applications (1)

Application Number Title Priority Date Filing Date
PL449074A PL449074A1 (en) 2024-06-29 2024-06-29 Recombinant protein and peptide with antimicrobial properties, compositions containing them, uses and methods using them

Country Status (2)

Country Link
PL (1) PL449074A1 (en)
WO (1) WO2026005624A1 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Baza danych NCBI [Protein]; https://www.ncbi.nlm.nih.gov/protein/ASE36562.1; 27 września 2019 (27.09.2019); "hypothetical protein CEP67_04465 [Staphylococcus pettenkoferi]; numer dostępu ASE36562.1 *
WYSOCKA A. ET AL.: "Front Microbiol. 2021 Sep 24;12:719689 doi:10.3389/fmicb.2021.719689.", TWO NEW M23 PEPTIDOGLYCAN HYDROLASES WITH DISTINCT NET CHARGE *
WYSOCKA A. ET AL.: "Microbiol Spectr. 2022 Jun 29;10(3):e0045522. doi: 10.1128/spectrum.00455-22", ELECTROSTATIC INTERACTION WITH THE BACTERIAL CELL ENVELOPE TUNES THE LYTIC ACTIVITY OF TWO NOVEL PEPTIDOGLYCAN HYDROLASES *

Also Published As

Publication number Publication date
WO2026005624A1 (en) 2026-01-02

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