PL449562A1 - Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X - Google Patents

Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X

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Publication number
PL449562A1
PL449562A1 PL449562A PL44956224A PL449562A1 PL 449562 A1 PL449562 A1 PL 449562A1 PL 449562 A PL449562 A PL 449562A PL 44956224 A PL44956224 A PL 44956224A PL 449562 A1 PL449562 A1 PL 449562A1
Authority
PL
Poland
Prior art keywords
zeolite
calcium
solution
crushed
dried
Prior art date
Application number
PL449562A
Other languages
Polish (pl)
Other versions
PL249177B1 (en
Inventor
Rafał Panek
Jakub Matusiak
Wojciech Franus
Agata Przekora-Kuśmierz
Paulina Kazimierczak
Alicja Wójcik
Original Assignee
Politechnika Lubelska
Uniwersytet Medyczny W Lublinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Lubelska, Uniwersytet Medyczny W Lublinie filed Critical Politechnika Lubelska
Priority to PL449562A priority Critical patent/PL249177B1/en
Publication of PL449562A1 publication Critical patent/PL449562A1/en
Publication of PL249177B1 publication Critical patent/PL249177B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/10—Metal compounds
    • C08K3/105—Compounds containing metals of Groups 1 to 3 or of Groups 11 to 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/34—Silicon-containing compounds
    • C08K3/36—Silica
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

Przedmiotem wynalazku jest sposób wytwarzania matrycy zeolitowo-polimerowej na bazie zeolitu wapniowego Ca-X polegający na przygotowaniu matrycy, w której skład wchodzi: sproszkowany zeolit Na-X poddaje się dwukrotnej wymianie jonowej dodając w proporcji 1 część proszku do 20 części (w/o) wodnego roztworu chlorku wapnia o stężeniu 1 M, ciągle mieszając, w temperaturze poniżej 60°C, po czym otrzymany zeolit wapniowy Ca-X suszy się i rozdrabnia; sproszkowany zeolit Ca-X miesza się w proporcji 1 część proszku do 20 części (w/o) 1% roztworu chitozanu w kwasie octowym o stężeniu 0,1 M, po czym mieszając dodaje się wodnego roztworu wodorotlenku sodu o stężeniu 1 M w ilości 20 ml do uzyskania pH=9, a następnie zmodyfikowany zeolit odsącza się z roztworu, suszy i rozdrabnia otrzymując CaXCH, zaś w dalszej kolejności dodaje się wodny roztwór ryzedronianu sodu o stężeniu 7,5 mg/ml w proporcji 1 część proszku do 20 części roztworu (w/o) - mieszając w temperaturze pokojowej, po czym osad oddziela się i suszy w temperaturze poniżej 70°C do otrzymania stałej masy, następnie matrycę CaXCHRIS rozdrabnia się. Matryca zeolitowo-chitozanowa zawierająca ryzedronian sodu (CaXCHRIS) charakteryzuje się kontrolowanym uwalnianiem substancji leczniczej w zależności od pH środowiska.The subject of the invention is a method for producing a zeolite-polymer matrix based on calcium zeolite Ca-X, consisting in preparing a matrix comprising: powdered Na-X zeolite is subjected to double ion exchange by adding 1 part of powder to 20 parts (w/o) of an aqueous solution of calcium chloride with a concentration of 1 M, under continuous stirring, at a temperature below 60°C, and then the obtained calcium zeolite Ca-X is dried and crushed; powdered zeolite Ca-X is mixed in the proportion of 1 part powder to 20 parts (w/o) of 1% chitosan solution in 0.1 M acetic acid, then 20 ml of 1 M sodium hydroxide aqueous solution is added under stirring to obtain pH=9, then the modified zeolite is filtered from the solution, dried and crushed to obtain CaXCH, and then an aqueous solution of sodium risedronate at a concentration of 7.5 mg/ml is added in the proportion of 1 part powder to 20 parts (w/o) solution - under stirring at room temperature, then the precipitate is separated and dried at a temperature below 70°C until a constant mass is obtained, then the CaXCHRIS matrix is crushed. The zeolite-chitosan matrix containing sodium risedronate (CaXCHRIS) is characterized by controlled release of the drug substance depending on the pH of the environment.

PL449562A 2024-08-22 2024-08-22 Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X PL249177B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL449562A PL249177B1 (en) 2024-08-22 2024-08-22 Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL449562A PL249177B1 (en) 2024-08-22 2024-08-22 Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X

Publications (2)

Publication Number Publication Date
PL449562A1 true PL449562A1 (en) 2025-02-03
PL249177B1 PL249177B1 (en) 2026-03-09

Family

ID=94381279

Family Applications (1)

Application Number Title Priority Date Filing Date
PL449562A PL249177B1 (en) 2024-08-22 2024-08-22 Method of producing a pH-responsive zeolite-polymer matrix based on calcium zeolite Ca-X

Country Status (1)

Country Link
PL (1) PL249177B1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL435810A1 (en) * 2020-10-29 2022-05-02 Politechnika Poznańska Titanium material for an implant and method for its production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL435810A1 (en) * 2020-10-29 2022-05-02 Politechnika Poznańska Titanium material for an implant and method for its production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAKUB MATUSIAK, AGATA PRZEKORA, WOJCIECH FRANUS: "Materials Today, Volume 67, July/August 2023", ZEOLITES AND ZEOLITE IMIDAZOLATE FRAMEWORKS ON A QUEST TO OBTAIN THE IDEAL BIOMATERIAL FOR BIOMEDICAL APPLICATIONS: A REVIEW *
MARIUSZ SANDOMIERSKI, KATARZYNA ADAMSKA, MARIA RATAJCZAK, ADAM VOELKEL: "International Journal of Biological Macromolecules 223 (2022) 812–820", CHITOSAN - ZEOLITE SCAFFOLD AS A POTENTIAL BIOMATERIAL IN THE CONTROLLED RELEASE OF DRUGS FOR OSTEOPOROSIS *
MARIUSZ SANDOMIERSKI, MONIKA ZIELIŃSKA, ADAM VOELKEL: "International Journal of Pharmaceutics Volume 578, 30 March 2020, 119117", CALCIUM ZEOLITES AS INTELLIGENT CARRIERS IN CONTROLLED RELEASE OF BISPHOSPHONATES *

Also Published As

Publication number Publication date
PL249177B1 (en) 2026-03-09

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