PL450284A1 - Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie - Google Patents

Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie

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Publication number
PL450284A1
PL450284A1 PL450284A PL45028424A PL450284A1 PL 450284 A1 PL450284 A1 PL 450284A1 PL 450284 A PL450284 A PL 450284A PL 45028424 A PL45028424 A PL 45028424A PL 450284 A1 PL450284 A1 PL 450284A1
Authority
PL
Poland
Prior art keywords
estrosphere
application
preparation
ester
subject
Prior art date
Application number
PL450284A
Other languages
English (en)
Inventor
Andrzej Antoni VOGT
Jerzy Aleksander GUBERNATOR
Adam MARKOWSKI
Original Assignee
Oncoturn Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoturn Spółka Z Ograniczoną Odpowiedzialnością filed Critical Oncoturn Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL450284A priority Critical patent/PL450284A1/pl
Priority to PCT/IB2025/061013 priority patent/WO2026104929A1/en
Publication of PL450284A1 publication Critical patent/PL450284A1/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Przedmiotem zgłoszenia jest preparat estrosfer zawierający fazę estrową i fazę wodną charakteryzujący się tym, że faza estrowa zawiera ester etylowy kwasu á-linolenowego albo mieszaninę estru etylowego kwasu á-linolenowego z jednym lub większą liczbą komponentów wybranych z grupy obejmującej estry etylowe WNKT lub trójglicerydy, emulgator oraz alkohol etylowy, w stosunku wagowym wynoszącym odpowiednio między 2:0,5:1 a 8:2:1, a faza wodna zawiera wodę z glicerolem w końcowym stężeniu 2,25% wag. Przedmiotem zgłoszenia jest również sposób wytwarzania takiego preparatu estrosfer, charakteryzujący się tym, że obejmuje etapy otrzymywania fazy estrowej, otrzymywania fazy wodnej oraz mieszania faz. Ponadto przedmiotem zgłoszenia jest zastosowanie preparatu estrosfer w profilaktyce i leczeniu nowotworów i chorób wirusowych.
PL450284A 2024-11-18 2024-11-18 Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie PL450284A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL450284A PL450284A1 (pl) 2024-11-18 2024-11-18 Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie
PCT/IB2025/061013 WO2026104929A1 (en) 2024-11-18 2025-10-29 Estrosphere preparation, method of production thereof and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL450284A PL450284A1 (pl) 2024-11-18 2024-11-18 Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie

Publications (1)

Publication Number Publication Date
PL450284A1 true PL450284A1 (pl) 2026-05-25

Family

ID=98223287

Family Applications (1)

Application Number Title Priority Date Filing Date
PL450284A PL450284A1 (pl) 2024-11-18 2024-11-18 Preparat estrosfer, sposób jego wytwarzania oraz zastosowanie

Country Status (2)

Country Link
PL (1) PL450284A1 (pl)
WO (1) WO2026104929A1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101978950A (zh) * 2010-11-16 2011-02-23 王京南 α-亚麻酸酯脂肪乳静脉注射液及其制造方法
CN103338746B (zh) * 2011-01-27 2015-12-23 太阳星光齿磨公司 含有多不饱和脂肪酸的组合物
CN108553419A (zh) * 2018-05-24 2018-09-21 安阳工学院 一种α-亚麻酸乙酯微乳液及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101978949A (zh) * 2010-11-16 2011-02-23 王京南 γ-亚麻酸酯脂肪乳静脉注射液及其制造方法
CN105726478A (zh) * 2016-01-28 2016-07-06 武汉欧米嘉生物医药有限公司 一种用于口服的epa o/w型纳米乳及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101978950A (zh) * 2010-11-16 2011-02-23 王京南 α-亚麻酸酯脂肪乳静脉注射液及其制造方法
CN103338746B (zh) * 2011-01-27 2015-12-23 太阳星光齿磨公司 含有多不饱和脂肪酸的组合物
CN108553419A (zh) * 2018-05-24 2018-09-21 安阳工学院 一种α-亚麻酸乙酯微乳液及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANAKA Y, GOTO K, MATSUMOTO Y, UEOKA R: "Int J Pharm. 2008 Jul 9;359(1-2):264-71. doi: 10.1016/j.ijpharm.2008.03.045", REMARKABLY HIGH INHIBITORY EFFECTS OF DOCOSAHEXAENOIC ACID INCORPORATED INTO HYBRID LIPOSOMES ON THE GROWTH OF TUMOR CELLS ALONG WITH APOPTOSIS *

Also Published As

Publication number Publication date
WO2026104929A1 (en) 2026-05-21