PL451300A1 - Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania - Google Patents

Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania

Info

Publication number
PL451300A1
PL451300A1 PL451300A PL45130025A PL451300A1 PL 451300 A1 PL451300 A1 PL 451300A1 PL 451300 A PL451300 A PL 451300A PL 45130025 A PL45130025 A PL 45130025A PL 451300 A1 PL451300 A1 PL 451300A1
Authority
PL
Poland
Prior art keywords
bisoprolol fumarate
ramipril
stable amorphous
preparation
amorphous forms
Prior art date
Application number
PL451300A
Other languages
English (en)
Inventor
Judyta Cielecka-Piontek
Szymon Sip
Original Assignee
Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu
Pikralida Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu, Pikralida Spółka Z Ograniczoną Odpowiedzialnością filed Critical Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu
Priority to PL451300A priority Critical patent/PL451300A1/pl
Publication of PL451300A1 publication Critical patent/PL451300A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania stabilnej formy amorficznej bisoprololu fumaranu oraz bisoprololu fumaranu z ramiprilem, wykorzystujący ekstrakcję CO2 w stanie nadkrytycznym. Przedmiotem zgłoszenia jest także stabilna forma amorficzna bisoprololu fumaranu, a także stabilna forma amorficzna bisoprololu fumaranu z ramiprilem.
PL451300A 2025-02-25 2025-02-25 Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania PL451300A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL451300A PL451300A1 (pl) 2025-02-25 2025-02-25 Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL451300A PL451300A1 (pl) 2025-02-25 2025-02-25 Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania

Publications (1)

Publication Number Publication Date
PL451300A1 true PL451300A1 (pl) 2025-09-01

Family

ID=96877547

Family Applications (1)

Application Number Title Priority Date Filing Date
PL451300A PL451300A1 (pl) 2025-02-25 2025-02-25 Stabilna forma amorficzna bisoprololu fumaranu i bisoprololu fumaranu z ramiprilem oraz sposób ich otrzymywania

Country Status (1)

Country Link
PL (1) PL451300A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349090B (zh) * 2016-07-28 2017-11-14 四川青木制药有限公司 一种富马酸比索洛尔ⅰ晶型及其制备方法
WO2021162562A2 (en) * 2020-02-10 2021-08-19 Adamed Pharma S.A. Stable ramipril composition and fixed dose composition comprising thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106349090B (zh) * 2016-07-28 2017-11-14 四川青木制药有限公司 一种富马酸比索洛尔ⅰ晶型及其制备方法
WO2021162562A2 (en) * 2020-02-10 2021-08-19 Adamed Pharma S.A. Stable ramipril composition and fixed dose composition comprising thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SKOTNICKI M, AGUILAR JA, PYDA M, HODGKINSON P.: "Pharm Res 32, 414–429 (2015)", BISOPROLOL AND BISOPROLOL-VALSARTAN COMPATIBILITY STUDIED BY DIFFERENTIAL SCANNING CALORIMETRY, NUCLEAR MAGNETIC RESONANCE AND X-RAY POWDER DIFFRACTOMETRY, DOI: https://doi.org/10.1007/s11095-014-1471- *

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