PL451580A1 - Chondrogenic peptides as chondrogenesis stimulators and their use - Google Patents

Chondrogenic peptides as chondrogenesis stimulators and their use

Info

Publication number
PL451580A1
PL451580A1 PL451580A PL45158025A PL451580A1 PL 451580 A1 PL451580 A1 PL 451580A1 PL 451580 A PL451580 A PL 451580A PL 45158025 A PL45158025 A PL 45158025A PL 451580 A1 PL451580 A1 PL 451580A1
Authority
PL
Poland
Prior art keywords
peptide
application
chondrogenesis
lys
cplg
Prior art date
Application number
PL451580A
Other languages
Polish (pl)
Inventor
Michał PIKUŁA
Agata Tymińska
Aneta Skoniecka
Małgorzata Zawrzykraj
Karolina Kondej
Sylwia RODZIEWICZ-MOTOWIDŁO
Natalia Karska
Agnieszka Kubiś
Piotr Skowron
Original Assignee
Uniwersytet Gdański
Gdański Uniwersytet Medyczny
Politechnika Gdańska
Innovabion Spółka Z Ograniczoną Odpowiedzialnością
Nex.D Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Gdański, Gdański Uniwersytet Medyczny, Politechnika Gdańska, Innovabion Spółka Z Ograniczoną Odpowiedzialnością, Nex.D Spółka Z Ograniczoną Odpowiedzialnością filed Critical Uniwersytet Gdański
Publication of PL451580A1 publication Critical patent/PL451580A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest peptyd oznaczony jako UG28, o sekwencji aminokwasowej Leu-Glu-Ala-Val-Asn-Pro-Lys-Tyr-Lys-Gln-Lys-Arg-Arg - (LEAVNPKYKQKRR) stanowiący środek o działaniu stymulującym chondrogenezę komórek mezenchymanych. Zgłoszenie obejmuje również zastosowanie medyczne peptydu UG28 jako leku w leczeniu uszkodzeń chrząstki jako stymulator chondrogenezę. Przedmiotem zgłoszenia jest peptyd oznaczony jako CPLG-UG28 zawierający na N-końcu resztę cysteiny ułatwiającej przyłączenie peptydu do maleimidochitozanu, z wykorzystaniem łącznika maleimidoglicynowego. Zgłoszenie obejmuje również zastosowanie medyczne peptydu CPLG-UG28 z przyłączonym biomateriałem jako biologiczny, biodegradowalny opatrunek stosowany w leczeniu zwyrodnień stawów, medycynie czaszkowo-szczękowo-twarzowej, czy chirurgii ortopedycznej.The subject of the application is a peptide designated UG28, with the amino acid sequence Leu-Glu-Ala-Val-Asn-Pro-Lys-Tyr-Lys-Gln-Lys-Arg-Arg - (LEAVNPKYKQKRR), which is an agent that stimulates chondrogenesis in mesenchymal cells. The application also covers the medical use of the UG28 peptide as a drug in the treatment of cartilage defects as a chondrogenesis stimulator. The subject of the application is a peptide designated CPLG-UG28 containing a cysteine residue at the N-terminus that facilitates the attachment of the peptide to maleimidochitosan using a maleimidoglycine linker. The application also covers the medical use of the CPLG-UG28 peptide with an attached biomaterial as a biological, biodegradable dressing used in the treatment of joint degeneration, craniosacral medicine, or orthopedic surgery.

PL451580A 2024-03-29 2025-03-26 Chondrogenic peptides as chondrogenesis stimulators and their use PL451580A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL448148A PL448148A1 (en) 2024-03-29 2024-03-29 Chondrogenic peptides as chondrogenesis stimulators and their use

Publications (1)

Publication Number Publication Date
PL451580A1 true PL451580A1 (en) 2025-10-06

Family

ID=97229882

Family Applications (2)

Application Number Title Priority Date Filing Date
PL448148A PL448148A1 (en) 2024-03-29 2024-03-29 Chondrogenic peptides as chondrogenesis stimulators and their use
PL451580A PL451580A1 (en) 2024-03-29 2025-03-26 Chondrogenic peptides as chondrogenesis stimulators and their use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL448148A PL448148A1 (en) 2024-03-29 2024-03-29 Chondrogenic peptides as chondrogenesis stimulators and their use

Country Status (1)

Country Link
PL (2) PL448148A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210221862A1 (en) * 2018-04-08 2021-07-22 Brim Biotechnology, Inc. Application of pedf-derived short peptides in the treatment of osteoarthritis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210221862A1 (en) * 2018-04-08 2021-07-22 Brim Biotechnology, Inc. Application of pedf-derived short peptides in the treatment of osteoarthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAMARERO-ESPINOSA, S., COOPER-WHITE, J.J.: "Biomaterials 2019, 210, 105-115.", COMBINATORIAL PRESENTATION OF CARTILAGE-INSPIRED PEPTIDES ON NANOPATTERNED SURFACES ENABLES DIRECTED DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS TOWARDS DISTINCT ARTICULAR CHONDROGENIC PHENOTYPES. *
PITOU, M., PAPACHRISTOU, E., BRATSIOS, D., KEFALA, G.-M., TSAGKARAKOU, A.S., LEONIDAS, D.D., AGGELI, A., PAPADOPOULOS, G.E., PAPI,: "Biomedicines 2023, 11, 3182.", VITRO CHONDROGENESIS INDUCTION BY SHORT PEPTIDES OF THE CARBOXY-TERMINAL DOMAIN OF TRANSFORMING GROWTH FACTOR Β1. *
ZHU, M., ZHONG, W., CA,O W., ZHANG, Q., WU, G.: "Bioact Mater 2021, 9, 221-238.", CHONDROINDUCTIVE /CHONDROCONDUCTIVE PEPTIDES AND THEIR-FUNCTIONALIZED BIOMATERIALS FOR CARTILAGE TISSUE ENGINEERING. *

Also Published As

Publication number Publication date
PL448148A1 (en) 2025-10-06

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