PT100850A - Composicoes farmaceuticas contendo uma mistura sinergica de um agente uricosurico, em especial,de probenecid, com um agente antagonista de aminoacidos excitantes, em especial,um derivado de quinoxalina substituido e sua utilizacao no tratamento de doencas neurodegenerativas - Google Patents

Composicoes farmaceuticas contendo uma mistura sinergica de um agente uricosurico, em especial,de probenecid, com um agente antagonista de aminoacidos excitantes, em especial,um derivado de quinoxalina substituido e sua utilizacao no tratamento de doencas neurodegenerativas

Info

Publication number: PT100850A
Authority: PT; Portugal
Prior art keywords: agent; probenecid; treatment; chinoxaline; aminoacides
Prior art date: 1991-09-09

Application number

PT100850A

Other languages

English (en)

Other versions

PT100850B (pt

Inventor

Graham Johnson

Christopher Franklin Bigge

Charles Price Taylor Jr

Devin Franklin Welty

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-09

Filing date

1992-09-08

Publication date

1993-10-29

1992-09-08 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1993-10-29 Publication of PT100850A publication Critical patent/PT100850A/pt

1999-07-30 Publication of PT100850B publication Critical patent/PT100850B/pt

Links

229940116731 Uricosuric agent Drugs 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 title abstract 2
229960003081 probenecid Drugs 0.000 title abstract 2
239000003383 uricosuric agent Substances 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
208000015122 neurodegenerative disease Diseases 0.000 title 1
150000003252 quinoxalines Chemical class 0.000 title 1
239000003194 amino acid receptor blocking agent Substances 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT100850A 1991-09-09 1992-09-08 Composicoes farmaceuticas contendo uma mistura sinergica de um agente uricosurico, em especial,de probenecid, com um agente antagonista de aminoacidos excitantes, em especial,um derivado de quinoxalina substituido e sua utilizacao no tratamento de doencas neurodegenerativas PT100850B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75640191A	1991-09-09	1991-09-09

Publications (2)

Publication Number	Publication Date
PT100850A true PT100850A (pt)	1993-10-29
PT100850B PT100850B (pt)	1999-07-30

Family

ID=25043303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100850A PT100850B (pt)	1991-09-09	1992-09-08	Composicoes farmaceuticas contendo uma mistura sinergica de um agente uricosurico, em especial,de probenecid, com um agente antagonista de aminoacidos excitantes, em especial,um derivado de quinoxalina substituido e sua utilizacao no tratamento de doencas neurodegenerativas

Country Status (16)

Country	Link
US (4)	US5407935A (pt)
EP (1)	EP0603301B1 (pt)
JP (1)	JP3218038B2 (pt)
AT (1)	ATE162075T1 (pt)
AU (1)	AU660717B2 (pt)
CA (1)	CA2115442C (pt)
DE (1)	DE69224069T2 (pt)
DK (1)	DK0603301T3 (pt)
ES (1)	ES2113957T3 (pt)
GR (1)	GR3026369T3 (pt)
MX (1)	MX9205127A (pt)
NO (1)	NO307645B1 (pt)
NZ (1)	NZ244243A (pt)
PT (1)	PT100850B (pt)
WO (1)	WO1993004688A1 (pt)
ZA (1)	ZA926837B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2115442C (en) *	1991-09-09	2003-09-23	Christopher Franklin Bigge	Pharmaceutical preparation containing an uricosuric agent and an excitatory amino acid antagonist
US5318985A (en) *	1991-12-20	1994-06-07	Merrell Dow Pharmaceuticals Inc.	Potentiation of NMDA antagonists
US5854217A (en)	1992-09-28	1998-12-29	Bearsden Bio, Inc.	Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
JPH07505908A (ja) *	1992-09-28	1995-06-29	マックセチーニ、マリア　ルイザ	Ｎｍｄａ受容体のアロステリックモジュレーター
AU735389B2 (en)	1996-07-22	2001-07-05	Cognetix, Inc.	Use of conantokins
EP0956292A4 (en)	1996-07-22	2003-07-30	Univ Utah Res Found	CONANTOKINES
US6277825B1 (en)	1996-07-22	2001-08-21	University Of Utah Research Foundation	Use of conantokins for treating pain
IL125950A0 (en) *	1997-09-05	1999-04-11	Pfizer Prod Inc	Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
WO1999061008A2 (en) *	1998-05-26	1999-12-02	Peter Louis Carlen	Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals
US6399574B1 (en)	2000-03-22	2002-06-04	University Of Utah Research Foundation	Use of conantokins
EP1317258B1 (en)	2000-06-28	2009-02-11	Merck & Co., Inc.	Use of allopurinol for the treatment of hypertension
US7276514B2 (en) *	2002-05-15	2007-10-02	Charitable Leadership Foundation - Medical Technology Acceleration Program	Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
US20080051428A1 (en) *	2002-05-15	2008-02-28	Davis Paul J	Pyrroloquinoline quinone drugs and methods of use thereof
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
CA2609972C (en) *	2004-03-22	2013-05-14	Apkarian Technologies Llc	Method and compositions for treatment of chronic neuropathic pain
US8461223B2 (en) *	2005-04-07	2013-06-11	Aspen Aerogels, Inc.	Microporous polycyclopentadiene-based aerogels
ITFI20050083A1 (it) *	2005-04-29	2006-10-30	Univ Firenze	Uso dell'acido chinurenico per la prevenzione e il trattamento dello shock
CA2607953A1 (en)	2005-05-09	2006-11-16	Tap Pharmaceutical Products, Inc.	Methods for treating nephrolithiasis
US9181486B2 (en)	2006-05-25	2015-11-10	Aspen Aerogels, Inc.	Aerogel compositions with enhanced performance
EP2338492A1 (en)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Methods and compositions for the treatment of alzheimer
AU2011299153B2 (en)	2010-09-10	2014-10-30	Takeda Pharmaceuticals U.S.A., Inc.	Methods for concomitant treatment of theophylline and febuxostat
US10806711B2 (en)	2011-08-12	2020-10-20	University Of Cincinnati	Method of treating acute decompensated heart failure with probenecid
AU2014244053B2 (en)	2013-03-13	2018-08-30	University Of Cincinnati	Treatment of a diastolic cardiac dysfunction with a TRPV2 receptor agonist
US20170143681A1 (en)	2015-11-02	2017-05-25	Apkarian Technologies Llc	Methods and compositions for treating pain
EP3427729A1 (en) *	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4812458A (en) *	1986-09-16	1989-03-14	A/S Ferrosan	6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
DK146787A (da) *	1987-03-23	1988-09-24	Ferrosan	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK0501378T3 (da) *	1991-02-28	1995-03-20	Merrell Dow Pharma	NMDA-antagonister
CA2115442C (en) *	1991-09-09	2003-09-23	Christopher Franklin Bigge	Pharmaceutical preparation containing an uricosuric agent and an excitatory amino acid antagonist

1992
- 1992-09-02 CA CA002115442A patent/CA2115442C/en not_active Expired - Fee Related
- 1992-09-02 DE DE69224069T patent/DE69224069T2/de not_active Expired - Fee Related
- 1992-09-02 AU AU25943/92A patent/AU660717B2/en not_active Ceased
- 1992-09-02 ES ES92919882T patent/ES2113957T3/es not_active Expired - Lifetime
- 1992-09-02 DK DK92919882T patent/DK0603301T3/da active
- 1992-09-02 AT AT92919882T patent/ATE162075T1/de not_active IP Right Cessation
- 1992-09-02 EP EP92919882A patent/EP0603301B1/en not_active Expired - Lifetime
- 1992-09-02 WO PCT/US1992/007540 patent/WO1993004688A1/en not_active Ceased
- 1992-09-02 JP JP50544593A patent/JP3218038B2/ja not_active Expired - Fee Related
- 1992-09-07 NZ NZ244243A patent/NZ244243A/en unknown
- 1992-09-08 PT PT100850A patent/PT100850B/pt not_active IP Right Cessation
- 1992-09-08 MX MX9205127A patent/MX9205127A/es not_active IP Right Cessation
- 1992-09-08 ZA ZA926837A patent/ZA926837B/xx unknown
1993
- 1993-04-19 US US08/049,228 patent/US5407935A/en not_active Expired - Fee Related
1994
- 1994-03-08 NO NO940809A patent/NO307645B1/no not_active IP Right Cessation
1995
- 1995-10-05 US US08/539,398 patent/US5627168A/en not_active Expired - Fee Related
1996
- 1996-12-31 US US08/775,637 patent/US5767119A/en not_active Expired - Fee Related
1998
- 1998-03-13 GR GR980400554T patent/GR3026369T3/el unknown
- 1998-03-27 US US09/049,495 patent/US5942513A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH06510544A (ja)	1994-11-24
DE69224069D1 (de)	1998-02-19
US5942513A (en)	1999-08-24
MX9205127A (es)	1993-07-01
DE69224069T2 (de)	1998-07-02
GR3026369T3 (en)	1998-06-30
PT100850B (pt)	1999-07-30
AU660717B2 (en)	1995-07-06
US5407935A (en)	1995-04-18
CA2115442C (en)	2003-09-23
US5767119A (en)	1998-06-16
EP0603301A1 (en)	1994-06-29
NO940809L (no)	1994-03-08
DK0603301T3 (da)	1998-09-14
NO940809D0 (no)	1994-03-08
WO1993004688A1 (en)	1993-03-18
US5627168A (en)	1997-05-06
ZA926837B (en)	1994-03-08
JP3218038B2 (ja)	2001-10-15
AU2594392A (en)	1993-04-05
NO307645B1 (no)	2000-05-08
EP0603301B1 (en)	1998-01-14
NZ244243A (en)	1995-07-26
ES2113957T3 (es)	1998-05-16
CA2115442A1 (en)	1993-03-18
ATE162075T1 (de)	1998-01-15

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Legal Events

Date

Code

Title

Description

1993-10-29

BB1A

Laying open of patent application

Effective date: 19930521

1999-07-30

FG3A

Patent granted, date of granting

Effective date: 19990416

2004-12-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20041018