PT1054018E - Bibliotecas de fragmentos fab e métodos para a sua utilização - Google Patents

Bibliotecas de fragmentos fab e métodos para a sua utilização Download PDF

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Publication number
PT1054018E
PT1054018E PT99201558T PT99201558T PT1054018E PT 1054018 E PT1054018 E PT 1054018E PT 99201558 T PT99201558 T PT 99201558T PT 99201558 T PT99201558 T PT 99201558T PT 1054018 E PT1054018 E PT 1054018E
Authority
PT
Portugal
Prior art keywords
methods
fab fragment
fragment libraries
fab
libraries
Prior art date
Application number
PT99201558T
Other languages
English (en)
Inventor
Hendricus Renerus J Hoogenboom
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of PT1054018E publication Critical patent/PT1054018E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT99201558T 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização PT1054018E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201558A EP1054018B1 (en) 1999-05-18 1999-05-18 Fab fragment libraries and methods for their use

Publications (1)

Publication Number Publication Date
PT1054018E true PT1054018E (pt) 2009-02-16

Family

ID=8240210

Family Applications (2)

Application Number Title Priority Date Filing Date
PT99201558T PT1054018E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização
PT91512335T PT2067788E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT91512335T PT2067788E (pt) 1999-05-18 1999-05-18 Bibliotecas de fragmentos fab e métodos para a sua utilização

Country Status (10)

Country Link
EP (2) EP1054018B1 (pt)
JP (3) JP4741086B2 (pt)
AT (1) ATE421976T1 (pt)
AU (1) AU780145B2 (pt)
CA (1) CA2372582C (pt)
DE (1) DE69940364D1 (pt)
DK (2) DK2067788T3 (pt)
ES (2) ES2549440T3 (pt)
PT (2) PT1054018E (pt)
WO (1) WO2000070023A1 (pt)

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US7803913B2 (en) 2002-05-06 2010-09-28 The United States Of America As Represented By The Department Of Health And Human Services Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
EP2314629B2 (en) 2002-07-18 2022-11-16 Merus N.V. Recombinant production of mixtures of antibodies
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
US20040072262A1 (en) * 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
CA2558873C (en) 2003-03-07 2015-10-20 New England Medical Center Hospitals, Inc. Treatment of iga1 deposition diseases
US7157562B1 (en) * 2003-04-14 2007-01-02 The United States Of America As Represented By The Secretary Of The Army Bioprocess for the production of recombinant anti-botulinum toxin antibody
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1704251A1 (en) * 2003-12-15 2006-09-27 Institut Pasteur Repertoire determination of a lymphocyte b population
JP4782700B2 (ja) 2004-01-20 2011-09-28 カロバイオス ファーマシューティカルズ インコーポレイティッド 最低限必須な結合決定基を用いた抗体特異性の移入
AU2005205412B2 (en) 2004-01-20 2011-08-11 Merus N.V. Mixtures of binding proteins
WO2005090407A1 (en) 2004-03-19 2005-09-29 Imclone Systems Incorporated Human anti-epidermal growth factor receptor antibody
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
EP1707628B1 (en) * 2005-03-30 2009-11-11 Sekisui Chemical Co., Ltd. Methods for producing recombinant polyclonal immunoglobulins
US8131480B2 (en) 2006-10-02 2012-03-06 Sea Lane Biotechnologies Llc Construction of diverse synthetic peptide and polypeptide libraries
CN101126760B (zh) * 2007-01-17 2011-11-16 江苏省人民医院 全人源抗卵泡刺激素β单链抗体筛选方法及其用途
US9365637B2 (en) 2010-02-19 2016-06-14 Japan Science And Technology Agency Antiviral agent, abzyme, primer set, method for producing polynucleotide, and method for producing polypeptide
AU2012245073B2 (en) 2011-04-21 2016-02-11 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
ES2618632T3 (es) 2011-09-28 2017-06-21 Zera Intein Protein Solutions, S.L. Inteínas divididas y usos de éstas
DK2838918T3 (da) 2012-04-20 2019-08-12 Merus Nv Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
EP2883883A1 (en) 2013-12-16 2015-06-17 Cardio3 Biosciences S.A. Therapeutic targets and agents useful in treating ischemia reperfusion injury
WO2016164308A1 (en) 2015-04-06 2016-10-13 Subdomain, Llc De novo binding domain containing polypeptides and uses thereof
PT3440208T (pt) * 2016-04-06 2020-12-04 Zumutor Biologics Inc Vetores para clonagem e expressão de proteínas, métodos e suas aplicações
US20200182884A1 (en) 2016-06-27 2020-06-11 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
EP3475706B1 (en) 2016-06-27 2021-08-11 Juno Therapeutics, Inc. Mhc-e restricted epitopes, binding molecules and related methods and uses
EP3612648A1 (en) 2017-04-18 2020-02-26 Université Libre de Bruxelles Biomarkers and targets for proliferative diseases
WO2019089982A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
BR112020009136A2 (pt) 2017-11-14 2020-10-13 Arcellx, Inc. polipeptídeos que contêm domínio d e usos dos mesmos
JP7390729B2 (ja) 2018-03-23 2023-12-04 ユニヴェルシテ リブル ドゥ ブリュッセル Ｗｎｔシグナル伝達アゴニスト分子
CA3106115A1 (en) 2018-07-08 2020-01-16 Specifica Inc. Antibody libraries with maximized antibody developability characteristics
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Also Published As

Publication number Publication date
CA2372582A1 (en) 2000-11-23
EP2067788B1 (en) 2015-07-22
JP2013078315A (ja) 2013-05-02
ATE421976T1 (de) 2009-02-15
DK1054018T3 (da) 2009-05-18
AU5142200A (en) 2000-12-05
AU780145B2 (en) 2005-03-03
EP1054018B1 (en) 2009-01-28
WO2000070023A9 (en) 2002-01-17
CA2372582C (en) 2013-08-13
WO2000070023A1 (en) 2000-11-23
ES2321568T3 (es) 2009-06-08
DE69940364D1 (de) 2009-03-19
DK2067788T3 (da) 2015-10-19
ES2549440T3 (es) 2015-10-28
HK1134303A1 (en) 2010-04-23
JP2002543830A (ja) 2002-12-24
JP4741086B2 (ja) 2011-08-03
JP5159841B2 (ja) 2013-03-13
JP2010273689A (ja) 2010-12-09
PT2067788E (pt) 2015-10-29
EP2067788A2 (en) 2009-06-10
EP1054018A1 (en) 2000-11-22
EP2067788A3 (en) 2010-04-21

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