PT115583A - Processo contínuo para a preparação de medicamentos anticolinérgicos - Google Patents

Processo contínuo para a preparação de medicamentos anticolinérgicos

Info

Publication number
PT115583A
PT115583A PT115583A PT11558319A PT115583A PT 115583 A PT115583 A PT 115583A PT 115583 A PT115583 A PT 115583A PT 11558319 A PT11558319 A PT 11558319A PT 115583 A PT115583 A PT 115583A
Authority
PT
Portugal
Prior art keywords
bromide
anticholinergic
preparation
medicines
continuous process
Prior art date
Application number
PT115583A
Other languages
English (en)
Other versions
PT115583B (pt
Inventor
Katz Marianna
Torres Lourenço Nuno
Original Assignee
Hovione Farm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=71120199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT115583(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hovione Farm Sa filed Critical Hovione Farm Sa
Priority to PT115583A priority Critical patent/PT115583B/pt
Priority to CN202080049646.2A priority patent/CN114206863A/zh
Priority to KR1020227000471A priority patent/KR20220024433A/ko
Priority to EP20734291.6A priority patent/EP3982923B1/en
Priority to JP2021574905A priority patent/JP2022549545A/ja
Priority to AU2020296972A priority patent/AU2020296972B2/en
Priority to US17/617,725 priority patent/US20220251078A1/en
Priority to PCT/GB2020/051448 priority patent/WO2020254791A1/en
Priority to CA3141271A priority patent/CA3141271A1/en
Publication of PT115583A publication Critical patent/PT115583A/pt
Priority to IL288972A priority patent/IL288972A/en
Publication of PT115583B publication Critical patent/PT115583B/pt
Priority to JP2025025794A priority patent/JP2025081547A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A PRESENTE INVENÇÃO REFERE-SE A UM NOVO PROCESSO PARA A PREPARAÇÃO DE AGENTES / FÁRMACOS ANTICOLINÉRGICOS, COMO BROMETO DE UMECLIDÍNIO, BROMETO DE TIOTRÓPIO, BROMETO DE GLICOPIRRÔNIO, BROMETO DE ACLIDÍNIO, BROMETO DE IPRATRÓPIO NO MODO DE FLUXO CONTÍNUO NA PRESENÇA DE UM OU MAIS SOLVENTES PRÓTICOS POLARES. OS MEDICAMENTOS ANTICOLINÉRGICOS ESTÃO EM UMA FORMA ADEQUADA PARA USO POR INALAÇÃO NO TRATAMENTO DE DOENÇAS RESPIRATÓRIAS, COMO ASMA OU DOENÇA PULMONAR OBSTRUTIVA CRÓNICA (DPOC).
PT115583A 2019-06-17 2019-06-17 Processo contínuo para a preparação de medicamentos anticolinérgicos PT115583B (pt)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PT115583A PT115583B (pt) 2019-06-17 2019-06-17 Processo contínuo para a preparação de medicamentos anticolinérgicos
CA3141271A CA3141271A1 (en) 2019-06-17 2020-06-16 Continuous process for the preparation of anticholinergic drugs
JP2021574905A JP2022549545A (ja) 2019-06-17 2020-06-16 抗コリン薬の調製のための連続プロセス
KR1020227000471A KR20220024433A (ko) 2019-06-17 2020-06-16 항콜린 약물의 연속 제조방법
EP20734291.6A EP3982923B1 (en) 2019-06-17 2020-06-16 Continuous process for the preparation of anticholinergic drugs
CN202080049646.2A CN114206863A (zh) 2019-06-17 2020-06-16 制备抗胆碱药的连续方法
AU2020296972A AU2020296972B2 (en) 2019-06-17 2020-06-16 Continuous process for the preparation of anticholinergic drugs
US17/617,725 US20220251078A1 (en) 2019-06-17 2020-06-16 Continuous Process for the Preparation of Anticholinergic Drugs
PCT/GB2020/051448 WO2020254791A1 (en) 2019-06-17 2020-06-16 Continuous process for the preparation of anticholinergic drugs
IL288972A IL288972A (en) 2019-06-17 2021-12-13 A continuous process for the preparation of anticholinergic drugs
JP2025025794A JP2025081547A (ja) 2019-06-17 2025-02-20 抗コリン薬の調製のための連続方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT115583A PT115583B (pt) 2019-06-17 2019-06-17 Processo contínuo para a preparação de medicamentos anticolinérgicos

Publications (2)

Publication Number Publication Date
PT115583A true PT115583A (pt) 2021-06-03
PT115583B PT115583B (pt) 2022-05-02

Family

ID=71120199

Family Applications (1)

Application Number Title Priority Date Filing Date
PT115583A PT115583B (pt) 2019-06-17 2019-06-17 Processo contínuo para a preparação de medicamentos anticolinérgicos

Country Status (10)

Country Link
US (1) US20220251078A1 (pt)
EP (1) EP3982923B1 (pt)
JP (2) JP2022549545A (pt)
KR (1) KR20220024433A (pt)
CN (1) CN114206863A (pt)
AU (1) AU2020296972B2 (pt)
CA (1) CA3141271A1 (pt)
IL (1) IL288972A (pt)
PT (1) PT115583B (pt)
WO (1) WO2020254791A1 (pt)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
WO2006117299A2 (en) 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Novel crystalline forms of tiotropium bromide
RU2453547C2 (ru) 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US8163913B2 (en) 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
JP5333342B2 (ja) 2009-06-29 2013-11-06 株式会社デンソー 半導体装置
SMT201700269T1 (it) * 2011-12-22 2017-07-18 Cerbios Pharma Sa Procedimento in continuo per l'alchilazione di ammine terziarie cicliche
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
BR112015003101B1 (pt) * 2012-08-15 2022-06-14 Glaxo Group Limited Processo para a preparação de um composto
CZ27764U1 (cs) 2014-08-22 2015-02-02 Zentiva, K.S. uMethanolový solvát umeclidinium bromidu
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
EP3248970A1 (en) 2016-05-27 2017-11-29 Zentiva K.S. Forms of umeclidinium bromide
PT109740B (pt) 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio

Also Published As

Publication number Publication date
IL288972A (en) 2022-02-01
EP3982923B1 (en) 2024-05-15
EP3982923A1 (en) 2022-04-20
JP2025081547A (ja) 2025-05-27
WO2020254791A1 (en) 2020-12-24
CA3141271A1 (en) 2020-12-24
EP3982923C0 (en) 2024-05-15
KR20220024433A (ko) 2022-03-03
PT115583B (pt) 2022-05-02
AU2020296972A1 (en) 2022-01-20
JP2022549545A (ja) 2022-11-28
AU2020296972B2 (en) 2025-04-24
CN114206863A (zh) 2022-03-18
US20220251078A1 (en) 2022-08-11

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Effective date: 20210531

FG3A Patent granted, date of granting

Effective date: 20220427