PT1230232E - 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao - Google Patents
4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacaoInfo
- Publication number
- PT1230232E PT1230232E PT00976912T PT00976912T PT1230232E PT 1230232 E PT1230232 E PT 1230232E PT 00976912 T PT00976912 T PT 00976912T PT 00976912 T PT00976912 T PT 00976912T PT 1230232 E PT1230232 E PT 1230232E
- Authority
- PT
- Portugal
- Prior art keywords
- caspases
- activators
- analogs
- cromene
- apoptose
- Prior art date
Links
- 102000011727 Caspases Human genes 0.000 title abstract 3
- 108010076667 Caspases Proteins 0.000 title abstract 3
- 239000012190 activator Substances 0.000 title abstract 3
- 208000034615 apoptosis-related disease Diseases 0.000 title 1
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 239000000411 inducer Substances 0.000 abstract 2
- 125000001819 4H-chromenyl group Chemical class O1C(=CCC2=CC=CC=C12)* 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004222 uncontrolled growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16358499P | 1999-11-05 | 1999-11-05 | |
| US18521100P | 2000-02-24 | 2000-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1230232E true PT1230232E (pt) | 2004-07-30 |
Family
ID=26859774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00976912T PT1230232E (pt) | 1999-11-05 | 2000-11-03 | 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6906203B1 (pt) |
| EP (1) | EP1230232B1 (pt) |
| JP (1) | JP2003513967A (pt) |
| AT (1) | ATE260269T1 (pt) |
| AU (1) | AU781986B2 (pt) |
| CA (1) | CA2390164C (pt) |
| DE (1) | DE60008574T2 (pt) |
| DK (1) | DK1230232T3 (pt) |
| ES (1) | ES2216987T3 (pt) |
| PT (1) | PT1230232E (pt) |
| SI (1) | SI1230232T1 (pt) |
| TR (1) | TR200401209T4 (pt) |
| WO (1) | WO2001034591A2 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1230232E (pt) * | 1999-11-05 | 2004-07-30 | Cytovia Inc | 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao |
| US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2002092083A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2002092076A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
| ES2337558T3 (es) * | 2001-05-16 | 2010-04-27 | Cytovia, Inc. | 4-h-cromenos sustituidos y analagos como activadores de caspasas e inductores de apoptosis y uso como agentes anticancerigenos. |
| US20050165053A1 (en) * | 2001-06-04 | 2005-07-28 | Cytovia, Inc. | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| AU2002353147A1 (en) * | 2001-12-13 | 2003-06-30 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
| WO2003097806A2 (en) * | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2003096982A2 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2004094647A2 (en) | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
| AU2005294430A1 (en) * | 2004-10-07 | 2006-04-20 | Cytovia, Inc. | Substituted N-aryl-1H-pyrazolo[3,4-b]quinolin-4-amines and analogs as activators of caspases and inducers of apoptosis |
| AU2006223257A1 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
| JP2009542701A (ja) | 2006-07-06 | 2009-12-03 | サイトビア インコーポレイティッド | カスパーゼの活性化因子およびアポトーシスの誘導因子としてのならびに抗血管剤としての置換された４−アリール−クロメンおよびその使用法 |
| US20080090234A1 (en) * | 2006-10-13 | 2008-04-17 | Kejian Zhang | Diagnostic assay for autoimmune lymphoproliferative syndrome (ALPS) and genetically related disorders |
| NZ585338A (en) | 2007-11-19 | 2012-08-31 | Howard Florey Inst | Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof |
| US8349864B2 (en) * | 2008-03-25 | 2013-01-08 | New Mexico Technical Research Foundation | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof |
| ES2331451B1 (es) | 2008-06-30 | 2010-10-21 | Consejo Superior De Investigaciones Cientificas (Csic) | Inmunosupresor basado en la interrupcion de la interaccion tcr-nck. |
| CN102171215B (zh) * | 2008-11-05 | 2014-06-18 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
| EP2638025B1 (en) * | 2010-11-12 | 2020-02-05 | Deutsches Krebsforschungszentrum (DKFZ) | Chromene derivatives and their analoga as wnt pathway antagonists |
| CN104185631A (zh) * | 2011-11-10 | 2014-12-03 | 纪念斯隆-凯特琳癌症中心 | 用2-氨基-4H-萘并[1,2-b]吡喃-3-甲腈治疗卵巢癌 |
| ES2534336B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno como inhibidores de la interacción TCR-Nck |
| ES2534318B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck |
| CN108358880A (zh) * | 2017-12-29 | 2018-08-03 | 五邑大学 | 一种4H-苯并[b]吡喃类化合物的合成方法 |
| CN108191806A (zh) * | 2017-12-29 | 2018-06-22 | 五邑大学 | 一种联苯型4H-苯并[b]吡喃类化合物的合成方法 |
| EP3759086A1 (en) | 2018-02-27 | 2021-01-06 | Artax Biopharma Inc. | Chromene derivatives as inhibitors of tcr-nck interaction |
| RU2674987C1 (ru) * | 2018-04-17 | 2018-12-14 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | 2-Аминия-7-(диэтиламино)-4-(4-метоксибензо[d][1,3]диоксол-5-ил)-4Н-хромен-3-карбонитрила N-ацетиламиноэтаноат, проявляющий противоопухолевую активность |
| RU2704262C1 (ru) * | 2018-12-27 | 2019-10-25 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | Производные 2-аминохроменов проявляющие противоопухолевую активность. Фармацевтические композиции |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8402047D0 (en) * | 1984-01-26 | 1984-02-29 | Fisons Plc | Nitrogen heterocycles |
| US5284868A (en) | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
| US5281619A (en) | 1992-09-25 | 1994-01-25 | Eli Lilly And Company | Therapy for diabetic complications |
| EP1004584A3 (en) * | 1992-11-18 | 2000-07-05 | Eli Lilly And Company Limited | Pyranoquinoline derivatives as inhibitors of cell proliferation |
| GB9306062D0 (en) | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
| EP0619314A1 (en) * | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H- naphtho(2,1-b)pyran derivatives and their pharmaceutical use |
| US6087160A (en) | 1993-06-24 | 2000-07-11 | The General Hospital Corporation | Programmed cell death genes and proteins |
| US5637589A (en) | 1993-10-29 | 1997-06-10 | University Of North Carolina At Chapel Hill | Suksdorfin, analogs, compositions thereof, and methods for making and using thereof |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| PL341661A1 (en) | 1997-10-10 | 2001-04-23 | Cytovia | Novel fluorescent reporter particles and their application in combination with testing capsizes |
| US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| WO1999054286A2 (en) | 1998-04-17 | 1999-10-28 | Parker Hughes Institute | Btk inhibitors and methods for their identification and use |
| EP1100496A4 (en) | 1998-07-21 | 2002-10-23 | Univ Jefferson | SMALL MOLECULES INHIBIT THE BCL-2 PROTEINS |
| KR20010102073A (ko) | 1999-02-11 | 2001-11-15 | 실버스타인 아써 에이. | 항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체 |
| PT1230232E (pt) * | 1999-11-05 | 2004-07-30 | Cytovia Inc | 4h-cromeno substituido e seus analogos como activadores de caspases e indutores de apoptose e sua utilizacao |
| WO2002092076A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
| ES2337558T3 (es) | 2001-05-16 | 2010-04-27 | Cytovia, Inc. | 4-h-cromenos sustituidos y analagos como activadores de caspasas e inductores de apoptosis y uso como agentes anticancerigenos. |
| US6858607B1 (en) * | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2002092083A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2003096982A2 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2003097806A2 (en) | 2002-05-16 | 2003-11-27 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
-
2000
- 2000-11-03 PT PT00976912T patent/PT1230232E/pt unknown
- 2000-11-03 EP EP00976912A patent/EP1230232B1/en not_active Expired - Lifetime
- 2000-11-03 JP JP2001536538A patent/JP2003513967A/ja active Pending
- 2000-11-03 AT AT00976912T patent/ATE260269T1/de not_active IP Right Cessation
- 2000-11-03 AU AU14619/01A patent/AU781986B2/en not_active Ceased
- 2000-11-03 SI SI200030376T patent/SI1230232T1/xx unknown
- 2000-11-03 DE DE60008574T patent/DE60008574T2/de not_active Expired - Lifetime
- 2000-11-03 DK DK00976912T patent/DK1230232T3/da active
- 2000-11-03 CA CA2390164A patent/CA2390164C/en not_active Expired - Fee Related
- 2000-11-03 WO PCT/US2000/030374 patent/WO2001034591A2/en not_active Ceased
- 2000-11-03 ES ES00976912T patent/ES2216987T3/es not_active Expired - Lifetime
- 2000-11-03 TR TR2004/01209T patent/TR200401209T4/xx unknown
- 2000-11-06 US US09/705,840 patent/US6906203B1/en not_active Expired - Fee Related
-
2005
- 2005-03-07 US US11/072,499 patent/US7507762B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6906203B1 (en) | 2005-06-14 |
| SI1230232T1 (en) | 2004-08-31 |
| DE60008574D1 (de) | 2004-04-01 |
| DK1230232T3 (da) | 2004-06-28 |
| WO2001034591A3 (en) | 2001-09-20 |
| DE60008574T2 (de) | 2009-10-01 |
| WO2001034591A2 (en) | 2001-05-17 |
| AU781986B2 (en) | 2005-06-23 |
| EP1230232A2 (en) | 2002-08-14 |
| CA2390164C (en) | 2011-03-29 |
| EP1230232B1 (en) | 2004-02-25 |
| ES2216987T3 (es) | 2004-11-01 |
| TR200401209T4 (tr) | 2004-07-21 |
| US7507762B2 (en) | 2009-03-24 |
| US20050154015A1 (en) | 2005-07-14 |
| AU1461901A (en) | 2001-06-06 |
| ATE260269T1 (de) | 2004-03-15 |
| CA2390164A1 (en) | 2001-05-17 |
| JP2003513967A (ja) | 2003-04-15 |
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