PT1509530E - 2-tia-dibenzoazulenos como inibidores da producao do factor de necrose tumoral e intermediarios para a producao destes - Google Patents

2-tia-dibenzoazulenos como inibidores da producao do factor de necrose tumoral e intermediarios para a producao destes

Info

Publication number: PT1509530E
Authority: PT; Portugal
Prior art keywords: production; necrosis factor; dibenzoazulenes; intermediaries; tia
Prior art date: 2002-04-10

Application number

PT03745849T

Other languages

English (en)

Inventor

Mercep Mladen

Mesic Milan

Pesic Dijana

Ozimec Ivana

Original Assignee

Pliva Istrazivacki Inst D O O

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-10

Filing date

2003-04-09

Publication date

2006-07-31

2003-04-09 Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O

2006-07-31 Publication of PT1509530E publication Critical patent/PT1509530E/pt

Links

238000004519 manufacturing process Methods 0.000 title abstract 4
108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
102000003390 tumor necrosis factor Human genes 0.000 title 1
102000000589 Interleukin-1 Human genes 0.000 abstract 2
108010002352 Interleukin-1 Proteins 0.000 abstract 2
230000005764 inhibitory process Effects 0.000 abstract 2
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
ZOJHYZMNGGBPBV-UHFFFAOYSA-N 4-thiatetracyclo[12.4.0.02,6.08,13]octadeca-1(18),2,6,8,10,12,14,16-octaene Chemical class C1SC=C2C3=C(C4=C(C=C12)C=CC=C4)C=CC=C3 ZOJHYZMNGGBPBV-UHFFFAOYSA-N 0.000 abstract 1
102100040247 Tumor necrosis factor Human genes 0.000 abstract 1
102000009270 Tumour necrosis factor alpha Human genes 0.000 abstract 1
108050000101 Tumour necrosis factor alpha Proteins 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT03745849T 2002-04-10 2003-04-09 2-tia-dibenzoazulenos como inibidores da producao do factor de necrose tumoral e intermediarios para a producao destes PT1509530E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20020305A HRP20020305A8 (en)	2002-04-10	2002-04-10	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof

Publications (1)

Publication Number	Publication Date
PT1509530E true PT1509530E (pt)	2006-07-31

Family

ID=28686903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT03745849T PT1509530E (pt)	2002-04-10	2003-04-09	2-tia-dibenzoazulenos como inibidores da producao do factor de necrose tumoral e intermediarios para a producao destes

Country Status (26)

Country	Link
US (1)	US7435834B2 (pt)
EP (1)	EP1509530B1 (pt)
JP (1)	JP2005526828A (pt)
CN (1)	CN1649875A (pt)
AT (1)	ATE320433T1 (pt)
AU (1)	AU2003259963A1 (pt)
BR (1)	BR0309094A (pt)
CA (1)	CA2481514A1 (pt)
CY (1)	CY1105036T1 (pt)
DE (1)	DE60304048T2 (pt)
DK (1)	DK1509530T3 (pt)
ES (1)	ES2260637T3 (pt)
HR (1)	HRP20020305A8 (pt)
IL (1)	IL164396A0 (pt)
IS (1)	IS7474A (pt)
MX (1)	MXPA04009943A (pt)
NO (1)	NO20044506L (pt)
NZ (1)	NZ535620A (pt)
PL (1)	PL372748A1 (pt)
PT (1)	PT1509530E (pt)
RU (1)	RU2334749C2 (pt)
SI (1)	SI1509530T1 (pt)
UA (1)	UA79277C2 (pt)
WO (1)	WO2003084962A1 (pt)
YU (1)	YU88304A (pt)
ZA (1)	ZA200408063B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020304B1 (en) *	2002-04-10	2008-04-30	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20020452A2 (en) *	2002-05-23	2004-02-29	Pliva D D	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030956A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
EP1968583A4 (en) *	2005-12-20	2010-09-15	Harvard College	COMPOUNDS, SCREENING AND TREATMENT PROCEDURES

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3711489A (en) *	1971-03-31	1973-01-16	Pfizer	Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
CA967573A (en)	1972-12-22	1975-05-13	Joseph G. Lombardino	Tetracyclic anti-inflammatory agents
NL7605526A (nl) *	1976-05-24	1977-11-28	Akzo Nv	Nieuwe tetracyclische derivaten.
US4198421A (en) *	1978-11-30	1980-04-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
FR2504140A1 (fr)	1981-04-16	1982-10-22	Centre Nat Rech Scient	Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
FI841399A7 (fi)	1983-04-12	1984-10-13	Ciba Geigy Ag	Polysykliset karboksyylihappoyhdisteet, menetelmä niiden valmistamiseksi ja näitä karboksyylihappoyhdisteitä sisältävät valmisteet sekä niiden käyttö.
IE62754B1 (en)	1988-08-26	1995-02-22	Akzo Nv	Tetracyclic antidepressants
IT1227527B (it)	1988-12-05	1991-04-12	Ciatti Maurizio	Spazzolino da denti a setole rotanti
RU2161159C2 (ru)	1994-11-02	2000-12-27	Жансен Фармасетика Н.В.	Замещенные тетрациклические производные оксазепина и тиазепина, способ их получения, композиция, обладающая антипсихотической активностью, и способ ее получения
US5552399A (en)	1994-11-02	1996-09-03	Janssen Pharmaceutica N.V.	Substituted tetracyclic azepine derivatives
ES2196328T3 (es)	1996-04-12	2003-12-16	Janssen Pharmaceutica Nv	Derivados de tetrahidrofurano tetraciclicos sustituidos.
UA52778C2 (uk) *	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20000310A2 (en)	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030957A2 (en)	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en)	2004-01-30	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders

2002
- 2002-04-10 HR HR20020305A patent/HRP20020305A8/xx not_active Application Discontinuation
2003
- 2003-04-09 RU RU2004132868/04A patent/RU2334749C2/ru not_active IP Right Cessation
- 2003-04-09 CA CA002481514A patent/CA2481514A1/en not_active Abandoned
- 2003-04-09 CN CNA038094932A patent/CN1649875A/zh active Pending
- 2003-04-09 PL PL03372748A patent/PL372748A1/xx not_active Application Discontinuation
- 2003-04-09 PT PT03745849T patent/PT1509530E/pt unknown
- 2003-04-09 MX MXPA04009943A patent/MXPA04009943A/es active IP Right Grant
- 2003-04-09 BR BR0309094-9A patent/BR0309094A/pt not_active IP Right Cessation
- 2003-04-09 IL IL16439603A patent/IL164396A0/xx unknown
- 2003-04-09 ES ES03745849T patent/ES2260637T3/es not_active Expired - Lifetime
- 2003-04-09 DE DE60304048T patent/DE60304048T2/de not_active Expired - Fee Related
- 2003-04-09 JP JP2003582159A patent/JP2005526828A/ja active Pending
- 2003-04-09 NZ NZ535620A patent/NZ535620A/xx unknown
- 2003-04-09 US US10/510,866 patent/US7435834B2/en not_active Expired - Fee Related
- 2003-04-09 DK DK03745849T patent/DK1509530T3/da active
- 2003-04-09 AU AU2003259963A patent/AU2003259963A1/en not_active Abandoned
- 2003-04-09 YU YU88304A patent/YU88304A/sh unknown
- 2003-04-09 AT AT03745849T patent/ATE320433T1/de not_active IP Right Cessation
- 2003-04-09 SI SI200330275T patent/SI1509530T1/sl unknown
- 2003-04-09 EP EP03745849A patent/EP1509530B1/en not_active Expired - Lifetime
- 2003-04-09 WO PCT/HR2003/000016 patent/WO2003084962A1/en not_active Ceased
- 2003-09-04 UA UA20041008547A patent/UA79277C2/uk unknown
2004
- 2004-09-27 IS IS7474A patent/IS7474A/is unknown
- 2004-10-06 ZA ZA200408063A patent/ZA200408063B/en unknown
- 2004-10-21 NO NO20044506A patent/NO20044506L/no not_active Application Discontinuation
2006
- 2006-05-18 CY CY20061100649T patent/CY1105036T1/el unknown

Also Published As

Publication number	Publication date
UA79277C2 (en)	2007-06-11
DE60304048T2 (de)	2006-10-19
US20050182126A1 (en)	2005-08-18
JP2005526828A (ja)	2005-09-08
ZA200408063B (en)	2006-07-26
EP1509530B1 (en)	2006-03-15
US7435834B2 (en)	2008-10-14
MXPA04009943A (es)	2005-09-30
NZ535620A (en)	2006-03-31
DE60304048D1 (de)	2006-05-11
IS7474A (is)	2004-09-27
ATE320433T1 (de)	2006-04-15
HRP20020305A8 (en)	2009-03-31
CN1649875A (zh)	2005-08-03
DK1509530T3 (da)	2006-07-17
AU2003259963A1 (en)	2003-10-20
RU2004132868A (ru)	2005-06-10
RU2334749C2 (ru)	2008-09-27
NO20044506L (no)	2004-11-09
IL164396A0 (en)	2005-12-18
HRP20020305A2 (en)	2003-10-31
WO2003084962A1 (en)	2003-10-16
ES2260637T3 (es)	2006-11-01
CY1105036T1 (el)	2010-03-03
SI1509530T1 (sl)	2006-08-31
BR0309094A (pt)	2005-02-09
PL372748A1 (en)	2005-08-08
CA2481514A1 (en)	2003-10-16
EP1509530A1 (en)	2005-03-02
YU88304A (sh)	2006-08-17

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