PT2145002E - Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos - Google Patents

Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos Download PDF

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Publication number
PT2145002E
PT2145002E PT88280797T PT08828079T PT2145002E PT 2145002 E PT2145002 E PT 2145002E PT 88280797 T PT88280797 T PT 88280797T PT 08828079 T PT08828079 T PT 08828079T PT 2145002 E PT2145002 E PT 2145002E
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Prior art keywords
bacterially
derived
nucleic acid
mammalian cells
vivo delivery
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PT88280797T
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English (en)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Toby Hulf
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Engeneic Molecular Delivery Pty Ltd
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Publication of PT2145002E publication Critical patent/PT2145002E/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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    • C12Y207/11021—Polo kinase (2.7.11.21)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/141—MicroRNAs, miRNAs
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PT88280797T 2007-03-30 2008-03-26 Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos PT2145002E (pt)

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US90907407P 2007-03-30 2007-03-30

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PT2145002E true PT2145002E (pt) 2015-04-29

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PT151501293T PT2865755T (pt) 2007-03-30 2008-03-26 Minicélulas intactas derivadas de bactéria compreendendo arn regulatório
PT88280797T PT2145002E (pt) 2007-03-30 2008-03-26 Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos

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PT151501293T PT2865755T (pt) 2007-03-30 2008-03-26 Minicélulas intactas derivadas de bactéria compreendendo arn regulatório

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EP (5) EP2532746A3 (pt)
JP (1) JP5167338B2 (pt)
CN (2) CN105854029B (pt)
AU (1) AU2008291833B2 (pt)
CA (3) CA2682704C (pt)
CY (1) CY1119031T1 (pt)
DK (2) DK2865755T3 (pt)
ES (2) ES2626179T3 (pt)
HR (2) HRP20150328T1 (pt)
LT (1) LT2865755T (pt)
MX (1) MX2009010411A (pt)
NZ (1) NZ580487A (pt)
PL (2) PL2865755T3 (pt)
PT (2) PT2865755T (pt)
SG (2) SG10201804257RA (pt)
SI (2) SI2865755T1 (pt)
WO (1) WO2009027830A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386640B1 (en) 2004-08-26 2015-01-28 EnGeneIC Molecular Delivery Pty Ltd Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
DK2865755T3 (en) * 2007-03-30 2017-05-15 Engeneic Molecular Delivery Pty Ltd BACTERIAL DERIVATIVE INTACT MINICELLS WITH REGULATORY RNA
DE102009017908A1 (de) * 2009-04-17 2010-10-21 Kist-Europe Forschungsgesellschaft Mbh Vektor für den Transport von mikrobiologischen Organismen zu Krankheitsherden
JP2013505232A (ja) * 2009-09-16 2013-02-14 スティヒティング ヘット ネーデルラント カンカー インスティテュート 癌治療のための薬剤標的としてのＦｒａ−１標的遺伝子
CA2858315C (en) 2011-12-13 2020-05-12 Engeneic Molecular Delivery Pty Ltd Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
US9006200B2 (en) 2013-03-13 2015-04-14 Asbestos Diseases Research Foundation MicroRNA-based approach to treating malignant pleural mesothelioma
SG11201602429QA (en) 2013-10-04 2016-04-28 Engeneic Molecular Delivery Pty Ltd Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma
CN106999444B (zh) * 2014-10-03 2023-12-12 安吉尼科分子传输公司 完整的细菌衍生的囊泡对小分子化合物的增强装载
AU2017339841B2 (en) * 2016-10-06 2024-11-14 Engeneic Molecular Delivery Pty Ltd Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same
AU2018256925B2 (en) 2017-04-28 2024-11-21 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
JP2021532106A (ja) 2018-07-23 2021-11-25 エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド 細菌由来ミニ細胞を含む組成物およびそれを使用する方法
CN113507936A (zh) 2019-01-04 2021-10-15 安吉尼科分子传输公司 用于治疗赘生性疾病的包封的糖脂抗原
EP4061802A4 (en) * 2019-12-23 2024-01-24 Agrospheres, Inc. Compositions and methods for enhanced uptake of active ingredients for animal health and nutrition

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4496778A (en) 1983-10-03 1985-01-29 Exxon Research & Engineering Co. Process for the hydroxylation of olefins using molecular oxygen, an osmium containing catalyst, a copper Co-catalyst, and an aromatic amine based promoter
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US6747002B2 (en) 1999-05-11 2004-06-08 Ortho-Mcneil Pharmaceutical, Inc. Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration
ATE541940T1 (de) 2001-10-15 2012-02-15 Engeneic Molecular Delivery Pty Ltd Intakte minizellen als vektoren für dna-transfer und gentherapie in vitro und in vivo
US20040053289A1 (en) * 2002-09-09 2004-03-18 The Regents Of The University Of California Short interfering nucleic acid hybrids and methods thereof
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
CN101954095B (zh) 2003-12-09 2013-03-13 基因分子传递股份有限公司 通过源自细菌的完整小细胞将靶基因递送至非吞噬哺乳动物细胞
EP1718338B1 (en) 2004-02-02 2015-05-06 EnGeneIC Molecular Delivery Pty Ltd. Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
EP2386640B1 (en) * 2004-08-26 2015-01-28 EnGeneIC Molecular Delivery Pty Ltd Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
DK2865755T3 (en) * 2007-03-30 2017-05-15 Engeneic Molecular Delivery Pty Ltd BACTERIAL DERIVATIVE INTACT MINICELLS WITH REGULATORY RNA

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EP2145002B1 (en) 2015-01-07
HK1209786A1 (en) 2016-04-08
LT2865755T (lt) 2017-07-25
HRP20170662T1 (hr) 2017-07-14
WO2009027830A2 (en) 2009-03-05
CA2682704C (en) 2014-07-08
ES2534435T3 (es) 2015-04-22
CN101715489B (zh) 2016-05-25
EP2532746A2 (en) 2012-12-12
EP2145002A2 (en) 2010-01-20
SG10201507969PA (en) 2015-10-29
EP3205724B1 (en) 2019-05-08
SI2865755T1 (sl) 2017-06-30
SG10201804257RA (en) 2018-06-28
SI2145002T1 (sl) 2015-05-29
EP2532746A3 (en) 2013-08-14
EP2865755B1 (en) 2017-02-01
EP3564372A1 (en) 2019-11-06
JP2010523487A (ja) 2010-07-15
AU2008291833B2 (en) 2012-11-08
AU2008291833A1 (en) 2009-03-05
HRP20150328T1 (hr) 2015-05-22
EP3205724A1 (en) 2017-08-16
PT2865755T (pt) 2017-05-26
EP2865755A2 (en) 2015-04-29
DK2145002T3 (en) 2015-04-20
CY1119031T1 (el) 2018-01-10
WO2009027830A3 (en) 2009-05-14
CN105854029A (zh) 2016-08-17
DK2865755T3 (en) 2017-05-15
CA2933978A1 (en) 2009-03-05
JP5167338B2 (ja) 2013-03-21
PL2145002T3 (pl) 2015-06-30
CN101715489A (zh) 2010-05-26
ES2626179T3 (es) 2017-07-24
EP2865755A3 (en) 2015-05-06
CN105854029B (zh) 2019-10-18
CA2844647A1 (en) 2009-03-05
NZ580487A (en) 2012-04-27
MX2009010411A (es) 2009-11-23
CA2844647C (en) 2016-07-26
CA2682704A1 (en) 2009-03-05
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PL2865755T3 (pl) 2017-08-31

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