PT2699580T - Análogos de diazonamida - Google Patents

Análogos de diazonamida

Info

Publication number
PT2699580T
PT2699580T PT127747616T PT12774761T PT2699580T PT 2699580 T PT2699580 T PT 2699580T PT 127747616 T PT127747616 T PT 127747616T PT 12774761 T PT12774761 T PT 12774761T PT 2699580 T PT2699580 T PT 2699580T
Authority
PT
Portugal
Prior art keywords
diazonamide analogs
diazonamide
analogs
Prior art date
Application number
PT127747616T
Other languages
English (en)
Inventor
Wei Qi
Zhou Ming
Xu Xiaoming
Caldwell Charles
Harran Susan
Wang Lai
Original Assignee
Joyant Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joyant Pharmaceuticals Inc filed Critical Joyant Pharmaceuticals Inc
Publication of PT2699580T publication Critical patent/PT2699580T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/424Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)
  • Thermistors And Varistors (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
PT127747616T 2011-04-22 2012-04-15 Análogos de diazonamida PT2699580T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161478059P 2011-04-22 2011-04-22

Publications (1)

Publication Number Publication Date
PT2699580T true PT2699580T (pt) 2018-01-04

Family

ID=47021791

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127747616T PT2699580T (pt) 2011-04-22 2012-04-15 Análogos de diazonamida

Country Status (22)

Country Link
US (2) US8592469B2 (pt)
EP (1) EP2699580B1 (pt)
JP (1) JP6045083B2 (pt)
KR (1) KR101839642B1 (pt)
CN (1) CN103582645B (pt)
AU (1) AU2012245702B2 (pt)
BR (1) BR112013027089A2 (pt)
CA (1) CA2833956C (pt)
DK (1) DK2699580T3 (pt)
ES (1) ES2652444T3 (pt)
HR (1) HRP20171930T1 (pt)
HU (1) HUE037730T2 (pt)
IL (1) IL228985A (pt)
LT (1) LT2699580T (pt)
MX (1) MX351961B (pt)
NO (1) NO2636579T3 (pt)
PL (1) PL2699580T3 (pt)
PT (1) PT2699580T (pt)
RU (1) RU2608308C2 (pt)
SG (1) SG194223A1 (pt)
SI (1) SI2699580T1 (pt)
WO (1) WO2012145255A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021130515A1 (en) 2019-12-23 2021-07-01 Latvian Institute Of Organic Synthesis Structurally simplified diazonamide analogs as antimitotic agents
WO2025114775A1 (en) * 2023-11-29 2025-06-05 Latvian Institute Of Organic Synthesis Macrocyclic tubulin polymerization inhibitors as anticancer agents

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5932566A (en) 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
JP2004501124A (ja) 2000-06-07 2004-01-15 リリー アイコス リミテッド ライアビリティ カンパニー 化合物
US7439359B2 (en) 2000-11-02 2008-10-21 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
US7022720B2 (en) 2001-08-24 2006-04-04 Board Of Regents, The University Of Texas System Synthetic diazonamides as novel anti-mitotic agents
US7517895B2 (en) * 2001-08-24 2009-04-14 Board Of Regents, The University Of Texas System Synthetic diazonamides
MXPA06002997A (es) 2003-09-18 2007-02-08 Conforma Therapeutics Corp Novedosos compuestos heterociclicos como inhibidores- hsp90.
EP1948169A4 (en) * 2005-10-31 2009-11-04 Univ Texas Diazonamide-A-ANALOG
WO2008154441A1 (en) * 2007-06-07 2008-12-18 Joyant Pharmaceuticals, Inc. Methods for preparing diazonamides
CN102014632B (zh) * 2008-04-29 2014-05-28 焦阳特制药股份有限公司 吲哚啉抗癌剂
US8153619B2 (en) * 2008-05-22 2012-04-10 Joyant Pharmaceuticals, Inc. Diazonamide analogs

Also Published As

Publication number Publication date
SI2699580T1 (en) 2018-04-30
BR112013027089A2 (pt) 2017-10-31
ES2652444T3 (es) 2018-02-02
US20120270841A1 (en) 2012-10-25
US8846734B2 (en) 2014-09-30
JP2014512384A (ja) 2014-05-22
CN103582645A (zh) 2014-02-12
JP6045083B2 (ja) 2016-12-14
WO2012145255A2 (en) 2012-10-26
AU2012245702A1 (en) 2013-11-07
CA2833956C (en) 2020-05-12
SG194223A1 (en) 2013-11-29
LT2699580T (lt) 2018-01-10
AU2012245702B2 (en) 2016-09-29
EP2699580A2 (en) 2014-02-26
RU2013148153A (ru) 2015-05-27
EP2699580A4 (en) 2014-12-31
RU2608308C2 (ru) 2017-01-17
HRP20171930T1 (hr) 2018-02-09
CN103582645B (zh) 2016-02-24
CA2833956A1 (en) 2012-10-26
PL2699580T3 (pl) 2018-03-30
KR20140053004A (ko) 2014-05-07
NZ616926A (en) 2015-09-25
MX351961B (es) 2017-10-17
HUE037730T2 (hu) 2018-09-28
MX2013012283A (es) 2014-07-09
KR101839642B1 (ko) 2018-03-16
US20140100193A1 (en) 2014-04-10
EP2699580B1 (en) 2017-09-27
DK2699580T3 (en) 2018-01-08
IL228985A0 (en) 2013-12-31
NO2636579T3 (pt) 2018-07-21
WO2012145255A3 (en) 2012-12-27
US8592469B2 (en) 2013-11-26
IL228985A (en) 2016-08-31

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