PT2970512T - Proteínas de fusão imunomoduladoras e métodos para produção das mesmas - Google Patents

Proteínas de fusão imunomoduladoras e métodos para produção das mesmas

Info

Publication number
PT2970512T
PT2970512T PT14779937T PT14779937T PT2970512T PT 2970512 T PT2970512 T PT 2970512T PT 14779937 T PT14779937 T PT 14779937T PT 14779937 T PT14779937 T PT 14779937T PT 2970512 T PT2970512 T PT 2970512T
Authority
PT
Portugal
Prior art keywords
immunomodulator
merger
proteins
methods
same production
Prior art date
Application number
PT14779937T
Other languages
English (en)
Inventor
Sastry Kedarnath
Melina Soares Maria
Govindappa Nagaraj
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of PT2970512T publication Critical patent/PT2970512T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
PT14779937T 2013-03-12 2014-03-10 Proteínas de fusão imunomoduladoras e métodos para produção das mesmas PT2970512T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361777016P 2013-03-12 2013-03-12

Publications (1)

Publication Number Publication Date
PT2970512T true PT2970512T (pt) 2019-01-17

Family

ID=51658871

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14779937T PT2970512T (pt) 2013-03-12 2014-03-10 Proteínas de fusão imunomoduladoras e métodos para produção das mesmas

Country Status (15)

Country Link
US (4) US9988456B2 (pt)
EP (1) EP2970512B1 (pt)
JP (2) JP6605444B2 (pt)
CN (1) CN105121474B9 (pt)
AU (2) AU2014249405C1 (pt)
BR (1) BR112015022733B1 (pt)
CA (2) CA2902830C (pt)
DK (1) DK2970512T3 (pt)
ES (1) ES2704411T3 (pt)
MY (1) MY186864A (pt)
NZ (1) NZ711445A (pt)
PL (1) PL2970512T3 (pt)
PT (1) PT2970512T (pt)
RU (2) RU2698975C2 (pt)
WO (1) WO2014164427A1 (pt)

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CN110734498A (zh) * 2019-10-15 2020-01-31 上海科棋药业科技有限公司 一种用于解除免疫抑制的融合蛋白及其应用
CN110964118A (zh) * 2019-11-27 2020-04-07 中国药科大学 一种双特异性融合抗体及其在肿瘤免疫治疗中的应用
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Also Published As

Publication number Publication date
BR112015022733A2 (pt) 2017-10-31
JP6605444B2 (ja) 2019-11-13
US20200399379A1 (en) 2020-12-24
US20180251560A1 (en) 2018-09-06
EP2970512B1 (en) 2018-10-10
ES2704411T3 (es) 2019-03-18
WO2014164427A1 (en) 2014-10-09
JP2019010111A (ja) 2019-01-24
BR112015022733B1 (pt) 2023-02-14
CA3081073C (en) 2023-09-12
JP2016512508A (ja) 2016-04-28
CA2902830C (en) 2023-09-19
CA3081073A1 (en) 2014-10-09
US12351636B2 (en) 2025-07-08
AU2014249405B2 (en) 2018-02-01
RU2662991C2 (ru) 2018-07-31
CN105121474B (zh) 2020-03-31
RU2018117558A3 (pt) 2019-01-30
RU2018117558A (ru) 2018-10-26
RU2015140608A (ru) 2017-04-18
AU2014249405A1 (en) 2015-10-29
US10766963B2 (en) 2020-09-08
NZ711445A (en) 2018-06-29
US9988456B2 (en) 2018-06-05
DK2970512T3 (en) 2019-01-14
US20250368743A1 (en) 2025-12-04
AU2014249405C1 (en) 2018-08-16
RU2698975C2 (ru) 2019-09-02
CN105121474A (zh) 2015-12-02
CA2902830A1 (en) 2014-10-09
HK1217343A1 (zh) 2017-01-06
EP2970512A1 (en) 2016-01-20
US20160009807A1 (en) 2016-01-14
PL2970512T3 (pl) 2019-03-29
CN105121474B9 (zh) 2020-06-19
EP2970512A4 (en) 2016-11-09
AU2018202982A1 (en) 2018-05-17
AU2018202982B2 (en) 2019-08-22
MY186864A (en) 2021-08-26

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