PT2995604T - Derivado de fenol e seu processo de preparação e utilização em medicina - Google Patents

Derivado de fenol e seu processo de preparação e utilização em medicina

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Publication number
PT2995604T
PT2995604T PT147955090T PT14795509T PT2995604T PT 2995604 T PT2995604 T PT 2995604T PT 147955090 T PT147955090 T PT 147955090T PT 14795509 T PT14795509 T PT 14795509T PT 2995604 T PT2995604 T PT 2995604T
Authority
PT
Portugal
Prior art keywords
medicine
preparation
phenol derivative
phenol
derivative
Prior art date
Application number
PT147955090T
Other languages
English (en)
Inventor
Qin Linlin
Li Fangqiong
Yi Shixu
Luo Huadong
Luo Xinfeng
Wan Songlin
Ren Lei
Liu Guoliang
Wei Yonggang
Liu Jianyu
Cho Tang Peng
Original Assignee
Sichuan Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan Haisco Pharmaceutical Co Ltd filed Critical Sichuan Haisco Pharmaceutical Co Ltd
Publication of PT2995604T publication Critical patent/PT2995604T/pt

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
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    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
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WO2016119757A1 (zh) * 2015-01-30 2016-08-04 四川海思科制药有限公司 一种2-[1-环烷基乙基]苯酚的制备方法及其中间体
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CN108164419B (zh) * 2017-12-25 2021-03-16 武汉大学 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
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MX2021003724A (es) * 2018-09-29 2021-05-14 Jiangsu Yahong Meditech Co Ltd Profarmaco de nitroxolina y su uso.
CN113105313A (zh) * 2020-01-11 2021-07-13 四川海思科制药有限公司 苯酚衍生物及其医药用途
CN111646936A (zh) * 2020-06-22 2020-09-11 江苏亚虹医药科技有限公司 芳香醚类化合物的制备方法
CN115175887B (zh) 2021-01-28 2023-08-01 天地恒一制药股份有限公司 苯酚衍生物及其在医药上的应用
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