PT3010896T - Derivados inovadores de amidino-ureia macrocíclicos, métodos de preparação e utilizações dos mesmos como inibidores de quitinase - Google Patents

Derivados inovadores de amidino-ureia macrocíclicos, métodos de preparação e utilizações dos mesmos como inibidores de quitinase

Info

Publication number
PT3010896T
PT3010896T PT147316251T PT14731625T PT3010896T PT 3010896 T PT3010896 T PT 3010896T PT 147316251 T PT147316251 T PT 147316251T PT 14731625 T PT14731625 T PT 14731625T PT 3010896 T PT3010896 T PT 3010896T
Authority
PT
Portugal
Prior art keywords
preparation
methods
new macrocyclic
chitinase inhibitors
derivatives
Prior art date
Application number
PT147316251T
Other languages
English (en)
Inventor
Sanfilippo Stefania
Posteraro Brunella
SANGUINETTI Maurizio
Botta Maurizio
Maccari Giorgio
DE LUCA Filomena
Docquier Jean-Denis
DEODATO Davide
Original Assignee
Cygnet Biosciences B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnet Biosciences B V filed Critical Cygnet Biosciences B V
Publication of PT3010896T publication Critical patent/PT3010896T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24Y being a hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT147316251T 2013-06-18 2014-06-18 Derivados inovadores de amidino-ureia macrocíclicos, métodos de preparação e utilizações dos mesmos como inibidores de quitinase PT3010896T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361836401P 2013-06-18 2013-06-18

Publications (1)

Publication Number Publication Date
PT3010896T true PT3010896T (pt) 2018-03-07

Family

ID=50979767

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147316251T PT3010896T (pt) 2013-06-18 2014-06-18 Derivados inovadores de amidino-ureia macrocíclicos, métodos de preparação e utilizações dos mesmos como inibidores de quitinase

Country Status (10)

Country Link
US (1) US10071975B2 (pt)
EP (1) EP3010896B1 (pt)
JP (1) JP6586416B2 (pt)
CN (1) CN105612147B (pt)
AU (1) AU2014283281C1 (pt)
BR (1) BR112015031820A2 (pt)
CA (1) CA2915767A1 (pt)
MX (1) MX363622B (pt)
PT (1) PT3010896T (pt)
WO (1) WO2014202697A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9135200B2 (en) 2013-06-28 2015-09-15 Futurewei Technologies, Inc. System and method for extended peripheral component interconnect express fabrics
EP3854789A1 (en) 2020-01-22 2021-07-28 Cygnet Biosciences B.V. Macrocyclic compounds useful as chitinase inhibitors
CN113773233B (zh) * 2021-09-18 2022-05-06 中国农业大学 一种甲基胍基脲衍生物及其制备方法与应用
CN115754090B (zh) * 2022-12-15 2023-08-29 华夏生生药业(北京)有限公司 一种lc-ms检测氟康唑相关杂质的方法
CN116425696B (zh) * 2023-04-19 2025-03-07 中国农业大学 氧杂二唑硝基苯胍基脲化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1114155A (en) * 1964-08-24 1968-05-15 Evans Medical Ltd Guanidino derivatives
PL2274290T3 (pl) * 2008-03-13 2013-03-29 Univ Degli Studi Di Siena Cykliczne pochodne guanidyny i ich zastosowania

Also Published As

Publication number Publication date
JP6586416B2 (ja) 2019-10-02
JP2016522236A (ja) 2016-07-28
BR112015031820A2 (pt) 2017-07-25
EP3010896A1 (en) 2016-04-27
US20160137617A1 (en) 2016-05-19
CN105612147B (zh) 2018-06-05
AU2014283281C1 (en) 2019-01-24
EP3010896B1 (en) 2017-11-01
MX2015017446A (es) 2016-08-12
CA2915767A1 (en) 2014-12-24
AU2014283281A1 (en) 2016-02-04
US10071975B2 (en) 2018-09-11
WO2014202697A1 (en) 2014-12-24
AU2014283281B2 (en) 2018-10-04
CN105612147A (zh) 2016-05-25
MX363622B (es) 2019-03-28

Similar Documents

Publication Publication Date Title
ZA201802315B (en) Methods of preparing nicotinamide riboside and derivatives thereof
IL245184B (en) Prostacyclin compounds, preparations and methods of using them
HUE048666T2 (hu) Mezõgazdasági endofita-növény kompozíciók és alkalmazási eljárások
HUE053122T2 (hu) Bipirazol-származékok mint JAK inhibitorok
SI2829539T1 (sl) Novi derivati pirola, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
EP3052489A4 (en) Use of macrocyclic picolinamides as fungicides
EP3086642A4 (en) Use of macrocyclic picolinamides as fungicides
EP3099170A4 (en) Use of macrocyclic picolinamides as fungicides
ZA201602198B (en) Preparation of hydroxy-benzylbenzene derivatives
SG11201601047SA (en) Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
PT3038656T (pt) Composto de glicosaminoglicano, método de preparação e sua utilização
ZA201604502B (en) Use of benzimidazole-proline derivatives
IL269622A (en) Preparation of (S–S)-scoisolaricirsinol diglucoside and (R–R)-scoisolaricisrinol diglucoside
EP3019477A4 (en) Heterocyclic compounds and methods of their use
SG11201510594YA (en) Mixtures of compounds, their preparation, and uses
EP3038622A4 (en) Heterocyclic compounds and methods of use
PL2988764T3 (pl) Kompozycje przeciwłupieżowe i sposoby ich zastosowania
EP2955174A4 (en) HOMOSERIN LACTONE DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
EP2952519A4 (en) PROTOPANOXADIOL DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
EP2986112A4 (en) PREPARATION AND USE OF FULVINIC ACID DERIVATIVES
EP2984113A4 (en) Photochemical preparation of hydroxyl-terminated polyisobutylenes and related methods and uses
EP2870133A4 (en) TETRAHYDRO ISOHUMULOD DERIVATIVES, METHOD FOR THE PREPARATION AND USE THEREOF
GB201412023D0 (en) Method of producting derivatives of 1,3,5-triarylbenzene and truxene
IL242464A0 (en) Macrocyclic derivatives of urea as tafia inhibitors, their preparation and use as pharmaceuticals
PT3083848T (pt) Composição e método para madeira ou derivados de madeira