PT3013833T - Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53 - Google Patents

Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53

Info

Publication number
PT3013833T
PT3013833T PT14739561T PT14739561T PT3013833T PT 3013833 T PT3013833 T PT 3013833T PT 14739561 T PT14739561 T PT 14739561T PT 14739561 T PT14739561 T PT 14739561T PT 3013833 T PT3013833 T PT 3013833T
Authority
PT
Portugal
Prior art keywords
oxazoloisoindolinones
tryptophanol
activators
molecule
derived
Prior art date
Application number
PT14739561T
Other languages
English (en)
Inventor
Helena Ataíde Saraiva Lucília
Manuel Duque Vieira Marques Dos Santos Maria
Alexandre Lousa Pereira Nuno
Isabel Ferreira Pereira Clara
Gomes Moreira Sara
Valencia Castanheira Ferreira Leão Mariana
Filipe Almeida Monteiro Ângelo
Oliveira Gama Soares Joana
Original Assignee
Univ Do Porto
Faculdade De Farmacia Da Univ De Lisboa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Do Porto, Faculdade De Farmacia Da Univ De Lisboa filed Critical Univ Do Porto
Publication of PT3013833T publication Critical patent/PT3013833T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT14739561T 2013-06-26 2014-06-26 Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53 PT3013833T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT10702513 2013-06-26

Publications (1)

Publication Number Publication Date
PT3013833T true PT3013833T (pt) 2019-03-20

Family

ID=51205527

Family Applications (1)

Application Number Title Priority Date Filing Date
PT14739561T PT3013833T (pt) 2013-06-26 2014-06-26 Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53

Country Status (4)

Country Link
US (1) US9732091B2 (pt)
EP (1) EP3013833B1 (pt)
PT (1) PT3013833T (pt)
WO (1) WO2014207688A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3810278A1 (en) 2018-06-20 2021-04-28 Universidade de Coimbra (3s)- and (3r)-6,7-bis(hydroxymethyl)-1h,3h-pyrrolo[1,2-c]thiazoles as p53 activators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1199306B1 (en) * 1999-07-26 2005-12-07 Banyu Pharmaceutical Co., Ltd. Biarylurea derivatives
EP1615639A2 (en) 2003-04-03 2006-01-18 Semafore Pharmaceuticals, Inc. Targeted bone marrow protection agents
WO2008005268A1 (en) * 2006-06-30 2008-01-10 Schering Corporation Substituted piperidines that increase p53 activity and the uses thereof
GB0818063D0 (en) 2008-10-02 2008-11-05 Univ Dundee Compounds
UA107652C2 (en) * 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds

Also Published As

Publication number Publication date
EP3013833B1 (en) 2019-03-06
EP3013833A1 (en) 2016-05-04
US9732091B2 (en) 2017-08-15
WO2014207688A1 (en) 2014-12-31
US20160347765A1 (en) 2016-12-01

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