PT3020732T - Um conjugado de imunoglobulina fc que mantêm a afinidade de ligação do fragmento de imunoglobulina fc à fcrn - Google Patents

Um conjugado de imunoglobulina fc que mantêm a afinidade de ligação do fragmento de imunoglobulina fc à fcrn

Info

Publication number
PT3020732T
PT3020732T PT148227218T PT14822721T PT3020732T PT 3020732 T PT3020732 T PT 3020732T PT 148227218 T PT148227218 T PT 148227218T PT 14822721 T PT14822721 T PT 14822721T PT 3020732 T PT3020732 T PT 3020732T
Authority
PT
Portugal
Prior art keywords
immunoglobulin
fcrn binding
binding strength
conjugate
maintaining fcrn
Prior art date
Application number
PT148227218T
Other languages
English (en)
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of PT3020732T publication Critical patent/PT3020732T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT148227218T 2013-07-12 2014-07-14 Um conjugado de imunoglobulina fc que mantêm a afinidade de ligação do fragmento de imunoglobulina fc à fcrn PT3020732T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20130082509 2013-07-12

Publications (1)

Publication Number Publication Date
PT3020732T true PT3020732T (pt) 2020-06-25

Family

ID=52280325

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148227218T PT3020732T (pt) 2013-07-12 2014-07-14 Um conjugado de imunoglobulina fc que mantêm a afinidade de ligação do fragmento de imunoglobulina fc à fcrn

Country Status (21)

Country Link
US (2) US20160152684A1 (pt)
EP (1) EP3020732B1 (pt)
JP (2) JP2016525099A (pt)
KR (2) KR101872559B1 (pt)
CN (2) CN116082528A (pt)
AR (1) AR096890A1 (pt)
AU (1) AU2014287879B2 (pt)
CA (1) CA2917838C (pt)
DK (1) DK3020732T3 (pt)
EA (1) EA034297B1 (pt)
ES (1) ES2799326T3 (pt)
HU (1) HU231424B1 (pt)
IL (1) IL243567B (pt)
MX (1) MX376370B (pt)
MY (1) MY180374A (pt)
NO (1) NO20160182A1 (pt)
PH (1) PH12016500111A1 (pt)
PT (1) PT3020732T (pt)
TW (1) TWI693236B (pt)
UA (1) UA119644C2 (pt)
WO (1) WO2015005747A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130049671A (ko) 2011-11-04 2013-05-14 한미사이언스 주식회사 생리활성 폴리펩타이드 결합체 제조 방법
AR090281A1 (es) 2012-03-08 2014-10-29 Hanmi Science Co Ltd Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
UA130573C2 (uk) * 2014-03-31 2026-03-25 Ханмі Фарм. Ко., Лтд. Спосіб покращення розчинності білка та пептиду із застосуванням зв'язування з fc-фрагментом імуноглобуліну
AR107483A1 (es) * 2016-01-29 2018-05-02 Hanmi Pharm Ind Co Ltd Conjugado de enzimas terapéuticas
KR20180071193A (ko) * 2016-12-19 2018-06-27 한미약품 주식회사 뇌 표적 지속성 단백질 결합체
KR102282240B1 (ko) 2018-12-06 2021-07-28 경상국립대학교산학협력단 지속형 엑센딘-4 및 이의 용도
WO2021010531A1 (ko) * 2019-07-18 2021-01-21 한미약품 주식회사 단백질 결합체의 신규 제조 방법
KR102382593B1 (ko) * 2020-01-29 2022-04-05 고려대학교 산학협력단 pH-감응성 Fc 변이체

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030613A (en) * 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
ATE279947T1 (de) 1996-03-18 2004-11-15 Univ Texas Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
CN1859925A (zh) * 2002-12-26 2006-11-08 山景医药公司 具有保留的受体结合活性的细胞因子、趋化因子、生长因子、多肽激素及其拮抗剂的聚合物缀合物
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
WO2005047337A1 (en) * 2003-11-13 2005-05-26 Hanmi Pharmaceutical Co., Ltd. A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
KR100609434B1 (ko) 2004-12-30 2006-08-03 한국항공우주연구원 트랜스버살 필터
KR100754667B1 (ko) * 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물
US7625564B2 (en) * 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
JP2008169195A (ja) * 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
KR20080098216A (ko) * 2007-05-04 2008-11-07 한미약품 주식회사 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체
KR100897938B1 (ko) * 2007-05-30 2009-05-18 주식회사 제넥신 면역글로불린 융합 단백질
JP2009019027A (ja) 2007-07-16 2009-01-29 Hanmi Pharmaceutical Co Ltd アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体
TWI388570B (zh) * 2008-07-23 2013-03-11 韓美科學有限公司 包含具有三個官能端的非肽醯聚合物的多肽複合物
BR112012022917A2 (pt) * 2010-03-11 2017-01-10 Pfizer anticorpos com ligação a antígeno dependente de ph
AR081066A1 (es) * 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
KR101337797B1 (ko) * 2010-07-14 2013-12-06 한미사이언스 주식회사 지속형 인간 성장 호르몬 결합체 액상 제제
KR101333958B1 (ko) * 2010-10-20 2013-11-27 주식회사 한독 인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질
UA113626C2 (xx) * 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
UA126465C2 (uk) 2011-06-10 2022-10-12 Ханмі Сайенс Ко., Лтд. Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить
PL2721062T3 (pl) * 2011-06-17 2019-05-31 Hanmi Science Co Ltd Koniugat zawierający oksyntomodulinę oraz fragment immunoglobuliny i jego zastosowanie
CN111053918A (zh) * 2011-09-05 2020-04-24 韩美科学株式会社 一种包含干扰素α-缀合物的抗癌用药物组合物
KR20130049671A (ko) * 2011-11-04 2013-05-14 한미사이언스 주식회사 생리활성 폴리펩타이드 결합체 제조 방법
KR102041412B1 (ko) * 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Ｆｃ 단편 유도체
AR094821A1 (es) * 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada

Also Published As

Publication number Publication date
AU2014287879B2 (en) 2020-01-02
WO2015005747A1 (ko) 2015-01-15
NO20160182A1 (en) 2016-03-02
US20160152684A1 (en) 2016-06-02
HUP1600206A2 (hu) 2016-05-30
CN116082528A (zh) 2023-05-09
TW201546093A (zh) 2015-12-16
MY180374A (en) 2020-11-28
TWI693236B (zh) 2020-05-11
EA034297B1 (ru) 2020-01-27
JP2020125337A (ja) 2020-08-20
NZ716275A (en) 2021-09-24
DK3020732T3 (da) 2020-06-15
CA2917838A1 (en) 2015-01-15
HK1221957A1 (en) 2017-06-16
HU231424B1 (hu) 2023-08-28
EA201690114A1 (ru) 2016-07-29
KR20150008011A (ko) 2015-01-21
KR101872559B1 (ko) 2018-06-28
EP3020732A4 (en) 2016-12-28
AR096890A1 (es) 2016-02-03
KR20180071241A (ko) 2018-06-27
US20220380437A1 (en) 2022-12-01
EP3020732A1 (en) 2016-05-18
UA119644C2 (uk) 2019-07-25
JP2016525099A (ja) 2016-08-22
MX376370B (es) 2025-03-07
CA2917838C (en) 2023-06-20
IL243567A0 (en) 2016-03-31
JP6880278B2 (ja) 2021-06-02
CN105593243A (zh) 2016-05-18
ES2799326T3 (es) 2020-12-16
EP3020732B1 (en) 2020-03-18
KR102076718B1 (ko) 2020-02-12
MX2016000344A (es) 2016-05-05
AU2014287879A1 (en) 2016-02-11
IL243567B (en) 2020-11-30
PH12016500111A1 (en) 2016-04-18

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