PT3079695T - Inibidores de glicosilceramida-sintase - Google Patents
Inibidores de glicosilceramida-sintaseInfo
- Publication number
- PT3079695T PT3079695T PT148242456T PT14824245T PT3079695T PT 3079695 T PT3079695 T PT 3079695T PT 148242456 T PT148242456 T PT 148242456T PT 14824245 T PT14824245 T PT 14824245T PT 3079695 T PT3079695 T PT 3079695T
- Authority
- PT
- Portugal
- Prior art keywords
- synthase inhibitors
- glucosylceramide synthase
- glucosylceramide
- inhibitors
- synthase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914842P | 2013-12-11 | 2013-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3079695T true PT3079695T (pt) | 2021-05-04 |
Family
ID=52282918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT148242456T PT3079695T (pt) | 2013-12-11 | 2014-12-09 | Inibidores de glicosilceramida-sintase |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20160361301A1 (pt) |
| EP (1) | EP3079695B1 (pt) |
| CN (2) | CN117679415A (pt) |
| CA (1) | CA2931981C (pt) |
| ES (1) | ES2871416T3 (pt) |
| IL (1) | IL245737B (pt) |
| PL (1) | PL3079695T3 (pt) |
| PT (1) | PT3079695T (pt) |
| SG (1) | SG10201804952QA (pt) |
| WO (1) | WO2015089067A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| JP2021506920A (ja) | 2017-12-21 | 2021-02-22 | リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
| CN114040762A (zh) | 2019-02-04 | 2022-02-11 | 建新公司 | 使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病 |
| AU2020218496B2 (en) | 2019-02-04 | 2024-12-19 | Genzyme Corporation | Methods for treating symptoms and disorders associated with lysosomal storage diseases |
| JP7636326B2 (ja) | 2019-07-29 | 2025-02-26 | 武田薬品工業株式会社 | 複素環化合物 |
| EP4005638A4 (en) | 2019-07-29 | 2023-07-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| TW202142236A (zh) | 2020-02-03 | 2021-11-16 | 美商健臻公司 | 用於治療與溶體儲積症相關的神經症狀之方法 |
| KR20230043024A (ko) * | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
| CN112798727B (zh) * | 2021-04-09 | 2021-07-06 | 宝枫生物科技（北京）有限公司 | 用于诊断脑白质病变的生物标志物f7及其应用 |
| CN121422228A (zh) * | 2025-12-31 | 2026-01-30 | 中日友好医院(中日友好临床医学研究所) | 葡糖神经酰胺水平作为心力衰竭的诊断和治疗靶点的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008232614A1 (en) * | 2007-03-30 | 2008-10-09 | Amicus Therapeutics, Inc. | Method for the treatment of Fabry disease using pharmacological chaperones |
| AU2012231275A1 (en) * | 2011-03-18 | 2013-10-17 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| JO3713B1 (ar) * | 2013-03-15 | 2021-01-31 | Genzyme Corp | أشكال ملح (s)-كوينوكليدين-3-يل(2-(2-(4-فلوروفينيل)ثيازول-4-يل)بروبان-2-يل)كارباميت |
-
2014
- 2014-12-09 PT PT148242456T patent/PT3079695T/pt unknown
- 2014-12-09 EP EP14824245.6A patent/EP3079695B1/en active Active
- 2014-12-09 ES ES14824245T patent/ES2871416T3/es active Active
- 2014-12-09 WO PCT/US2014/069338 patent/WO2015089067A1/en not_active Ceased
- 2014-12-09 SG SG10201804952QA patent/SG10201804952QA/en unknown
- 2014-12-09 CN CN202311444367.8A patent/CN117679415A/zh active Pending
- 2014-12-09 US US15/108,686 patent/US20160361301A1/en not_active Abandoned
- 2014-12-09 CN CN201480075230.2A patent/CN105979945A/zh active Pending
- 2014-12-09 CA CA2931981A patent/CA2931981C/en active Active
- 2014-12-09 PL PL14824245T patent/PL3079695T3/pl unknown
-
2016
- 2016-05-19 IL IL245737A patent/IL245737B/en active IP Right Grant
-
2018
- 2018-04-05 US US15/946,355 patent/US20190046509A1/en not_active Abandoned
-
2022
- 2022-05-25 US US17/824,552 patent/US20220409595A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3079695A1 (en) | 2016-10-19 |
| US20160361301A1 (en) | 2016-12-15 |
| CN117679415A (zh) | 2024-03-12 |
| SG10201804952QA (en) | 2018-07-30 |
| CA2931981C (en) | 2022-05-03 |
| CA2931981A1 (en) | 2015-06-18 |
| ES2871416T3 (es) | 2021-10-28 |
| IL245737B (en) | 2020-04-30 |
| IL245737A0 (en) | 2016-07-31 |
| CN105979945A (zh) | 2016-09-28 |
| WO2015089067A1 (en) | 2015-06-18 |
| EP3079695B1 (en) | 2021-03-17 |
| US20220409595A1 (en) | 2022-12-29 |
| PL3079695T3 (pl) | 2021-09-27 |
| US20190046509A1 (en) | 2019-02-14 |
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